Phospholipid transport to the bacterial outer membrane through an envelope-spanning bridge

Kavli Affiliate: Robert E. Clark | Authors: Georgia Isom, Benjamin F Cooper, Robert Clark, Anju Kudhail, Damian Charles Ekiert, Gira Bhabha and Syma Khalid | Summary: The outer membrane of Gram-negative bacteria provides a formidable barrier, essential for both pathogenesis and antimicrobial resistance. Biogenesis of the outer membrane requires the transport of phospholipids across the […]


Continue.. Phospholipid transport to the bacterial outer membrane through an envelope-spanning bridge

Structure-Function Coupling in Highly Sampled Individual Brains

Kavli Affiliate: Deanna J. Greene | Authors: Aishwarya Rajesh, Nicole A. Seider, Dillan J. Newbold, Babatunde Adeyemo, Scott Marek, Deanna J. Greene, Abraham Z Snyder, Joshua S. Shimony, Timothy O Laumann, Nico U.F. Dosenbach and Evan M. Gordon | Summary: Structural connections (SC) between distant regions of the brain support synchronized function known as functional […]


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Fe-TAMLs as a new class of small molecule peroxidase probes for correlated light and electron microscopy

Kavli Affiliate: Mark Ellisman | Authors: Stephen R Adams, Mason R Mackey, Ranjan Ramachandra, Thomas J Deerinck, Guillaume A Castillon, Sebastien Phan, Junru Hu, Daniela Boassa, John T Ngo and Mark H Ellisman | Summary: We introduce Fe-TAML, a small molecule-based peroxidase as a versatile new member of the correlated fluorescence and electron microscopy toolkit. […]


Continue.. Fe-TAMLs as a new class of small molecule peroxidase probes for correlated light and electron microscopy

Scaling use of the rust fungus Puccinia punctiformis for biological control of Canada thistle (Cirsium arvense (L.) Scop.): First report on a U.S. statewide effort

Kavli Affiliate: Robert E. Clark | Authors: Dan W. Bean, Kristi Gladem, Karen Rosen, Alexander Blake, Robert E. Clark, Caitlin Henderson, John Kaltenbach, Joel Price, Emily L. Smallwood, Dana K. Berner, Stephen L. Young and Robert N. Schaeffer | Summary: Canada thistle (Cirsium arvense (L.) Scop., CT) is one of the worst weeds threatening temperate […]


Continue.. Scaling use of the rust fungus Puccinia punctiformis for biological control of Canada thistle (Cirsium arvense (L.) Scop.): First report on a U.S. statewide effort

Leveraging the Adolescent Brain Cognitive Development Study to improve behavioral prediction from neuroimaging in smaller replication samples

Kavli Affiliate: Timothy Brown, Anders Dale | Authors: Carolina Makowski, Timothy T Brown, Weiqi Zhao, Donald J Hagler, Pravesh Parekh, Hugh Garavan, Thomas E Nichols, Terry L Jernigan and Anders M Dale | Summary: Magnetic resonance imaging (MRI) is a popular and useful non-invasive method to map patterns of brain structure and function to complex […]


Continue.. Leveraging the Adolescent Brain Cognitive Development Study to improve behavioral prediction from neuroimaging in smaller replication samples

Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional phenotypes in Down Syndrome

Kavli Affiliate: Nicola Allen | Authors: Ashley N Brandebura, Quinn N Asbell, Mariel Kristine B Micael and Nicola J Allen | Summary: Neuronal dendrite structure and synapse formation is tightly regulated during development to promote proper connectivity. Astrocyte-secreted proteins act as guidance and pro-synaptogenic factors, and astrocyte protein secretion is dysregulated in neurodevelopmental disorders with […]


Continue.. Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional phenotypes in Down Syndrome

Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy

Kavli Affiliate: Mark Ellisman | Authors: Guillaume A Castillon, Sebastien Phan, Junru Hu, Daniela Boassa, Stephen R Adams and Mark H Ellisman | Summary: The binding and interaction of proteins with nucleic acids such as DNA and RNA constitutes a fundamental biochemical and biophysical process in all living organisms. Identifying and visualizing such temporal interactions […]


Continue.. Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy

Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a tropical multi–host community

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Our understanding of pathogen spillover is largely based on viral systems associated with bats. Bacterial infections of zoonotic origin also pose a significant public health burden, many of which are associated with small […]


Continue.. Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a tropical multi–host community

ImAge: an imaging approach to quantitate aging and rejuvenation

Kavli Affiliate: Tatyana Sharpee | Authors: Martin Alvarez-Kuglen, Delany Rodriguez, Haodong Qin, Kenta Ninomiya, Lorenzo Fiengo, Chen Farhy, Aaron Havas, Wei-Mien Hsu, Gen-Sheng Feng, Amanda Roberts, Rozalyn M Anderson, Manuel Serrano, Peter D Adams, Tatyana O Sharpee and Alexey Terskikh | Summary: Biomarkers of biological age that predict the risk of disease and expected lifespan […]


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MCell4 with BioNetGen: A Monte Carlo Simulator of Rule-Based Reaction-Diffusion Systems with Python Interface

Kavli Affiliate: Terrence Sejnowski | Authors: Adam Husar, Mariam Ordyan, Guadalupe C Garcia, Joel G Yancey, Ali S Saglam, James Faeder, Thomas M Bartol, Jr., Mary B Kennedy and Terrence J Sejnowski | Summary: Biochemical signaling pathways in living cells are often highly organized into spatially segregated volumes, membranes, scaffolds, subcellular compartments, and organelles comprising […]


Continue.. MCell4 with BioNetGen: A Monte Carlo Simulator of Rule-Based Reaction-Diffusion Systems with Python Interface