Kavli Affiliate: Nicola Allen | Authors: Ashley N Brandebura, Quinn N Asbell, Mariel Kristine B Micael and Nicola J Allen | Summary: Neuronal dendrite structure and synapse formation is tightly regulated during development to promote proper connectivity. Astrocyte-secreted proteins act as guidance and pro-synaptogenic factors, and astrocyte protein secretion is dysregulated in neurodevelopmental disorders with […]

Kavli Affiliate: Mark Ellisman | Authors: Guillaume A Castillon, Sebastien Phan, Junru Hu, Daniela Boassa, Stephen R Adams and Mark H Ellisman | Summary: The binding and interaction of proteins with nucleic acids such as DNA and RNA constitutes a fundamental biochemical and biophysical process in all living organisms. Identifying and visualizing such temporal interactions […]

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Our understanding of pathogen spillover is largely based on viral systems associated with bats. Bacterial infections of zoonotic origin also pose a significant public health burden, many of which are associated with small […]

Kavli Affiliate: Tatyana Sharpee | Authors: Martin Alvarez-Kuglen, Delany Rodriguez, Haodong Qin, Kenta Ninomiya, Lorenzo Fiengo, Chen Farhy, Aaron Havas, Wei-Mien Hsu, Gen-Sheng Feng, Amanda Roberts, Rozalyn M Anderson, Manuel Serrano, Peter D Adams, Tatyana O Sharpee and Alexey Terskikh | Summary: Biomarkers of biological age that predict the risk of disease and expected lifespan […]

Kavli Affiliate: Terrence Sejnowski | Authors: Adam Husar, Mariam Ordyan, Guadalupe C Garcia, Joel G Yancey, Ali S Saglam, James Faeder, Thomas M Bartol, Jr., Mary B Kennedy and Terrence J Sejnowski | Summary: Biochemical signaling pathways in living cells are often highly organized into spatially segregated volumes, membranes, scaffolds, subcellular compartments, and organelles comprising […]

Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, David Kleinfeld, Beth Friedman and Yoav Freund | Summary: One routine and necessary, yet time-consuming task in neuroanatomy is the annotation of labeled cells relative to the background. Currently, staining and imaging techniques enable the marking of specific cell groups with fluorescent dyes. Modern high throughput scanning […]

Kavli Affiliate: John Serences | Authors: Margaret M Henderson, John T Serences and Nuttida Rungratsameetaweemana | Summary: Everyday visual search tasks require objects to be categorized according to behavioral goals. For example, when searching for an apple at the supermarket, one might first find the Granny Smith apples by separating all visible apples into the […]

Kavli Affiliate: Terrence Sejnowski | Authors: Antonio Pinto-Duarte, Katharine Bogue, Terrence J. Sejnowski and Shyam Srinivasan | Summary: The organizational principles of glia remain largely unknown despite their vital role in nervous system function. Previous work has shown that the number of glia per unit volume of neocortex is constant across mammalian species. We hypothesize […]

Kavli Affiliate: Mark Ellisman | Authors: Kailash Venkatraman, Christopher T Lee, Guadalupe C. Garcia, Arijit Mahapatra, Guy Perkins, Keun-Young Kim, Hilda Amalia Pasolli, Sebastien Phan, Jennifer Lippincott-Schwartz, Mark Ellisman, Padmini Rangamani and Itay Budin | Summary: Cristae are high curvature structures in the inner mitochondrial membrane (IMM) that are crucial for ATP production. While cristae-shaping […]