An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options

Posted by klaurent Hopkins

Kavli Affiliate: Jin Kang | Authors: Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst and Robert Landick | Summary: Abstract Transcriptional pausing underpins regulation of cellular RNA synthesis but its mechanism remains incompletely understood. Sequence-specific interactions of DNA and RNA with the dynamic, multidomain RNA polymerase […]


Continue.. An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options

Two Synaptic Convergence Motifs Define Functional Roles for Inputs to Cochlear Nucleus Bushy Cells

Posted by klaurent UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: George A. Spirou, Matthew Kersting, Sean Carr, Bayan Razzaq, Carolyna Y. Alves-Pinto, Mariah Dawson, Mark H. Ellisman and Paul B. Manis | Summary: Abstract Bushy neurons of the cochlear nucleus encode temporal fine structure and modulation of sound with high fidelity. However, the synaptic maps and electrotonic structures that […]


Continue.. Two Synaptic Convergence Motifs Define Functional Roles for Inputs to Cochlear Nucleus Bushy Cells

Postsynaptic receptors regulate presynaptic neurotransmitter stability

Posted by klaurent UCSD / Salk

Kavli Affiliate: Nicholas Spitzer | Authors: Swetha K Godavarthi, Masateru Hiramoto, Yuri Ignatyev, Jacqueline B Levin, Huiquan Li, Marta Pratelli, Jennifer Borchardt, Cynthia M Czajkowski, Laura N Borodinsky, Lora Sweeney, Hollis Tremaine Cline and Nicholas C Spitzer | Summary: Abstract Alteration of the electrical activity of the nervous system causes plasticity in neural circuits. Many […]


Continue.. Postsynaptic receptors regulate presynaptic neurotransmitter stability

Global remapping in granule cells and mossy cells of the mouse dentate gyrus

Posted by klaurent Hopkins

Kavli Affiliate: James Knierim | Authors: Sang Hoon Kim, Douglas GoodSmith, Stephanie J Temme, Fumika Moriya, Guo-li Ming, Kimberly Christian, Hongjun Song and James J Knierim | Summary: SUMMARY Hippocampal place cells exhibit spatially modulated firing, or place fields, which can remap to encode changes in the environment or other variables. Unique among hippocampal subregions, […]


Continue.. Global remapping in granule cells and mossy cells of the mouse dentate gyrus

Imaging through Windansee electrode arrays reveals a small fraction of local neurons following surface MUA

Posted by klaurent UCSD / Salk

Kavli Affiliate: Shadi Dayeh & Vikash Gilja | Authors: Martin Thunemann, Lorraine Hossain, Torbjørn V Ness, Nicholas Rogers, Keundong Lee, Sang-Heong Lee, Kıvılcım Kılıç, Hongseok Oh, Michael Nicholas Economo, Vikash Gilja, Gaute Einevoll, Shadi Dayeh and Anna Devor | Summary: Abstract Prior studies have shown that neuronal spikes can be recorded with microelectrode arrays placed […]


Continue.. Imaging through Windansee electrode arrays reveals a small fraction of local neurons following surface MUA

Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis

Posted by klaurent UCSD / Salk

Kavli Affiliate: Dwight Bergles | Authors: Yiming Chao, Yang Xiang, Jiashun Xiao, Shihui Zhang, Weizhong Zheng, Xiaomeng Wan, Zhuoxuan LI, Mingze Gao, Gefei Wang, Zhilin Chen, Mo Ebrahimkhani, Can Yang, Angela Ruohao Wu, Pentao Liu, Yuanhua Huang and Ryohichi Sugimura | Summary: Abstract Single-cell level characterization of embryonic development is a major benchmark of human […]


Continue.. Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis

A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Marysia Placzek, Kavitha Chinnaiya, Sarah Burbridge, Aragorn Jones, Dong Won Kim, Elsie Place, Elizabeth Manning, Ian Groves, Changyu Sun, Matthew Towers and Seth Blackshaw | Summary: Abstract The tuberal hypothalamus houses several major hypothalamic nuclei, dozens of transcriptionally distinct cell types, and clinically relevant cell populations implicated in obesity […]


Continue.. A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

Regional and LTP-Dependent Variation of Synaptic Information Storage Capacity in Rat Hippocampus

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Mohammad Samavat, Thomas M Bartol, Cailey Bromer, Jared B Bowden, Dusten D Hubbard, Dakota C Hanka, Masaaki Kuwajima, John M Mendenhall, Patrick H Parker, Wickliffe C Abraham, Kristen M Harris and Terrence J Sejnowski | Summary: Abstract Synapses from the same axon onto the same dendrite have a common […]


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Membrane remodeling properties of the Parkinson’s disease protein LRRK2

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xinbo Wang, Javier Espadas, Yumei Wu, Shujun Cai, Jinghua Ge, Lin Shao, Aurélien Roux and Pietro De Camilli | Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) are responsible for late-onset autosomal dominant Parkinson’s disease (PD). LRRK2 has been implicated in a wide range of physiological processes including membrane […]


Continue.. Membrane remodeling properties of the Parkinson’s disease protein LRRK2

Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Tsai-Yi Lu, Priyanka Hanumaihgari, Eric T Hsu, Amit Agarwal and Dwight E Bergles | Summary: Abstract Oligodendrocytes are generated from a widely distributed population of progenitors that express neurotransmitter receptors, but the mechanisms that alter activity of these oligodendrocyte precursor cells (OPCs) in vivo have not been determined. We […]


Continue.. Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal