Neuroscience – Page 94 – Kavli Institute Pre-Print Publications

Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria vector

Posted by klaurent February 6, 2023February 13, 2023Columbia

Kavli Affiliate: Scott Small | Authors: Scott T Small, Carlo Costantini, N’Fale Sagnon, Moussa W Guelbeogo, Scott J Emrich, Andrew D Kern, Michael C Fontaine and Nora J Besansky | Summary: Abstract Local adaptation results in the formation of ecotypes–conspecific groups with heritable differences that increase fitness to distinct environments. The adaptive significance of ecotypes […]

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The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex

Posted by klaurent UCSF

Kavli Affiliate: Arturo Alvarez-Buylla, Andrea Hasenstaub, Michael Stryker | Authors: Walter R Mancia Leon, David M Steffen, Fiona Dale-Huang, Benjamin Rakela, Arnar Breevoort, Ricardo Romero-Rodriguez, Andrea R Hasenstaub, Michael P Stryker, Joshua A Weiner and Arturo Alvarez-Buylla | Summary: Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory interneurons (cINs) are born in the ventral […]

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Construction of a 3D whole organism spatial atlas by joint modeling of multiple slices

Posted by klaurent February 3, 2023February 13, 2023UCSD / Salk

Kavli Affiliate: Angela Wu | Authors: Gefei Wang, Jia Zhao, Yan Yan, Yang Wang, Angela Ruohao Wu and Can Yang | Summary: Spatial transcriptomics (ST) technologies are revolutionizing the way that researchers explore the spatial architecture of tissues. Currently, ST data analysis is often restricted to 2D space within a single tissue slice, limiting our […]

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Auditory memory of complex sounds in sparsely distributed, highly correlated neurons in the auditory cortex

Posted by klaurent February 3, 2023February 13, 2023Hopkins

Kavli Affiliate: Patrick Kanold | Authors: HiJee Kang and Patrick O Kanold | Summary: Listening in complex sound environments requires rapid segregation of different sound sources e.g., speakers from each other, speakers from other sounds, or different instruments in an orchestra, and also adjust auditory processing on the prevailing sound conditions. Thus, fast encoding of […]

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The double-drift illusion biases the marmoset oculomotor system

Posted by klaurent February 3, 2023February 13, 2023UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Nicholas M Dotson, Zachary W Davis, Jared M Salisbury, Stephanie E Palmer, Patrick Cavanagh and John Reynolds | Summary: Abstract The double-drift illusion has two unique characteristics: the error between the perceived and physical position of the stimulus grows over time, and saccades to the moving target land much […]

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Histone bivalency regulates the timing of cerebellar granule cell development

Posted by klaurent February 3, 2023February 13, 2023Rockefeller

Kavli Affiliate: Mary E. Hatten, C. David Allis | Authors: Kärt Mätlik, Eve-Ellen Govek, Matthew R. Paul, C. David Allis and Mary E. Hatten | Summary: Abstract Developing neurons undergo a progression of morphological and gene expression changes as they transition from neuronal progenitors to mature, multipolar neurons. Here we use RNA-seq and H3K4me3 and […]

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Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Posted by klaurent January 30, 2023February 7, 2023UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Anders Dale, Eivind Hovig and Ole Andreassen | Summary: Abstract Discoveries from genome-wide association studies often contain large clusters of highly correlated genetic variants, which makes them hard to interpret. In such cases, finemapping the underlying causal variants […]

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Performant web-based interactive visualization tool for spatially-resolved transcriptomics experiments

Posted by klaurent January 29, 2023March 7, 2023Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Chaichontat Sriworarat, Annie B. Nguyen, Nicholas J. Eagles, Leonardo Collado-Torres, Keri Martinowich, Kristen R. Maynard and Stephanie C. Hicks | Summary: High-resolution and multiplexed imaging techniques are giving us an increasingly detailed observation of a biological system. However, sharing, exploring, and customizing the visualization of large multidimensional images can […]

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Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Posted by klaurent January 28, 2023February 7, 2023Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Alicia M Braxton, Ashley L Kiemen, Mia P Grahn, Andre Forjaz, Jaanvi Mahesh Babu, Lily Zheng, Liping Jiang, Haixia Cheng, Qianqian Song, Rebecca Reichel, Sarah Graham, Alexander I Damanakis, Catherine G Fischer, Stephanie Mou, Cameron Metz, Julie Granger, Xiao-Ding Liu, Niklas Bachmann, Cristina Almagro-Perez, Ann Chenyu Jiang, Jeonghyun Yoo, […]

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Contribution of protein conformational heterogeneity to NMR lineshapes at cryogenic temperatures

Posted by klaurent January 25, 2023February 7, 2023Columbia

Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Keith Fritzsching, Rivkah Rogawski, Yunyao Xu and Ann E McDermott | Summary: While low temperature NMR holds great promise for the analysis of unstable samples and for sensitizing NMR detection, spectral broadening in frozen protein samples is a common experimental challenge. One hypothesis explaining the additional linewidth […]

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