Identification of dendritic cell-T cell interactions driving immune responses to food

Posted by klaurent Rockefeller

Kavli Affiliate: Daniel S. Mucida | Authors: Maria Cecilia C. Canesso, Tiago Bruno Castro, Sandra Nakandakari-Higa, Ainsley Lockhart, Daria Esterhazy, Bernardo Sgarbi Reis, Gabriel D Victora and Daniel Mucida | Summary: Abstract The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Dendritic cells (DCs) orchestrate these immune responses by presenting […]


Continue.. Identification of dendritic cell-T cell interactions driving immune responses to food

Localized APP pathology in the hippocampus is sufficient to result in progressive disorganization of the timing of neuronal firing patterns

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jill Leutgeb | Authors: Silvia Viana da Silva, Matthias G Haberl, Kshitij Gaur, Rina Patel, Gautam Narayan, Max Ledakis, Maylin L. Fu, Edward H. Koo, Jill K. Leutgeb and Stefan Leutgeb | Summary: Abstract Deficits in spatial navigation are among the early symptoms in Alzheimer’s disease patients, consistent with the hippocampal formation as […]


Continue.. Localized APP pathology in the hippocampus is sufficient to result in progressive disorganization of the timing of neuronal firing patterns

Mechanotransduction events at the physiological site of touch detection

Posted by klaurent Yale

Kavli Affiliate: Elena Gracheva | Authors: Luke H. Ziolkowski, Elena O. Gracheva and Sviatoslav N. Bagriantsev | Summary: Abstract Afferents of peripheral mechanoreceptors innervate the skin of vertebrates, where they detect physical touch via mechanically gated ion channels (mechanotransducers). While the afferent terminal is generally understood to be the primary site of mechanotransduction, the functional […]


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Species-wide genomics of kākāpō provides transformational tools to accelerate recovery

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Joseph G Guhlin, Marissa F. Le Lec, Jana Wold, Emily Koot, David Winter, Patrick Biggs, Stephanie J Galla, Lara Urban, Yasmin Foster, Murray P Cox, Andrew Digby, Lydia Uddstrom, Daryl Eason, Deidre Vercoe, Tāne Davis, Kākāpō Recovery Team, Jason T Howard, Erich J Jarvis, Fiona E Robertson, Bruce C […]


Continue.. Species-wide genomics of kākāpō provides transformational tools to accelerate recovery

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

Posted by klaurent UCSF

Kavli Affiliate: Shankar Sundaram | Authors: Thomas A. Desautels, Kathryn T. Arrildt, Adam T. Zemla, Edmond Y. Lau, Fangqiang Zhu, Dante Ricci, Stephanie Cronin, Seth J. Zost, Elad Binshtein, Suzanne M. Scheaffer, Taylor B. Engdahl, Elaine Chen, John W. Goforth, Denis Vashchenko, Sam Nguyen, Dina R. Weilhammer, Jacky Kai-Yin Lo, Bonnee Rubinfeld, Edwin A. Saada, […]


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A conserved principle of glial organization in the paleocortex and neocortex

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Antonio Pinto-Duarte, Katherine Bogue, Terrence J Sejnowski and Shyam Srinivasan | Summary: Abstract The neocortex and paleocortex process sensory information and take part in higher cognitive tasks such as decision-making. The environment of the circuits within these regions is largely controlled by glial cells. Studies have shown that, across […]


Continue.. A conserved principle of glial organization in the paleocortex and neocortex

A Computational Model for Storing Memories in the Synaptic Structures of the Brain

Posted by klaurent UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Vivek K George, Vikash N Morar and Gabriel A Silva | Summary: Abstract Spike-timing dependent plasticity (STDP) is widely accepted as a mechanism through which the brain can learn information from different stimuli. Basing synaptic changes on the timing between presynaptic and postsynaptic spikes enhances contributing edges within a […]


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Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales Ramirez, Adrian Pelin, Jyoti Batra, Gwendolyn M. Jang, Jiewei Xu, Jack M. Moen, Alicia L. Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, […]


Continue.. Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Frederic Bibollet-Ruche, Ronnie M Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, Rumi Habib, Ashwin N Skelly, Ryan S Roark, Scott Sherrill-Mix, Shuyi Wang, Juliette Rando, Emily Lindemuth, Kendra Cruickshank, Younghoon Park, Rachel Baum, Andrew Connell, Hui Li, Elena E Giorgi, Ge S Song, Shilei Ding, […]


Continue.. A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

Microscopic Imaging of Epigenetic Age

Posted by klaurent UCSD / Salk

Kavli Affiliate: Tatyana Sharpee | Authors: Delany Rodriguez, Lorenzo Fiengo, Martin Alvarez-Kuglen, Haodong Qin, Chen Farhy, Aaron Havas, Rozalyn M Anderson, Peter D Adams, Tatyana O Sharpee and Alexey Terskikh | Summary: ABSTRACT Predictive biomarkers of functional or biological age are key for evaluating interventions aimed at increasing healthspan and / or lifespan in humans. […]


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