Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant

Posted by dbos Rockefeller

Kavli Affiliate: Daniel Kronauer | Authors: Kip D Lacy, Jina Lee, Kathryn Rozen-Gagnon, Wei Wang, Thomas S Carroll and Daniel J C Kronauer | Summary: Sex determination is a developmental switch that triggers sex-specific developmental programs. This switch is “flipped” by the expression of genes that promote male- or female-specific development. Many lineages have evolved […]


Continue.. Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant

The geometry of the neural state space of decisions

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Mauro M. Monsalve-Mercado and Kenneth D Miller | Summary: How do populations of neurons collectively encode and process information during cognitive tasks? We analyze high-yield population recordings from the macaque lateral intraparietal area (LIP) during a reaction-time random-dot-motion direction-discrimination task. We find that the trajectories of neural population activity […]


Continue.. The geometry of the neural state space of decisions

Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Kenneth D Miller and Agostina Palmigiano | Summary: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of […]


Continue.. Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

Adaptation shapes the representational geometry in mouse V1 to efficiently encode the environment

Posted by dbos Columbia

Kavli Affiliate: Stefano Fusi and Kenneth Miller | Authors: Mario Dipoppa, Ramon Nogueira, Stéphane Bugeon, Yoni Friedman, Charu B. Reddy, Kenneth D. Harris, Dario L. Ringach, Kenneth D. Miller, Matteo Carandini and Stefano Fusi | Summary: Allogeneic stem cell transplant (alloSCT) for patients with relapsed/refractory chronic lymphocytic Sensory adaptation dynamically changes neural responses as a […]


Continue.. Adaptation shapes the representational geometry in mouse V1 to efficiently encode the environment

Evolution of chronic lymphocytic leukemia after allogeneic stem cell transplant

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Haven R Garber, Danwei Wang, Celine Kerros, Hannah C Beird, Xizeng Mao, Nina G Howard, Jianhua Zhang, Jason Roszik, John P Miller, Paul Leonard, Yu Cao, Li Zhao, Xingzhi Song, Sahil Seth, Pei Lin, Huandong Sun, Lisa S St John, Sijie Lu, William Wierda, Issa F Khouri, Karen Clise-Dwyer, […]


Continue.. Evolution of chronic lymphocytic leukemia after allogeneic stem cell transplant

Mitochondrial ROS and HIF-1α signalling mediate critical period plasticity

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Daniel Sobrid-Camean, Bramwell Coulson, Michael Miller, Matthew CW Oswald, Tom Pettini, Richard A Baines and Matthias Landgraf | Summary: As developing networks transition from spontaneous irregular to patterned activity, they undergo plastic tuning phases, termed “critical periods”; “critical” because disturbances during these phases can lead to lasting changes in […]


Continue.. Mitochondrial ROS and HIF-1α signalling mediate critical period plasticity

Automatic detection of fluorescently labeled synapses in volumetric in vivo imaging data

Posted by dbos Hopkins

Kavli Affiliate: Adam S. Charles and Richard Huganir | Authors: Zhining Chen, Gabrielle I. Coste, Evan Li, Richard L. Huganir, Austin R. Graves and Adam Charles | Summary: Synapses are submicron structures that connect and enable communication between neurons. Many forms of learning are thought to be encoded by synaptic plasticity, wherein the strength of […]


Continue.. Automatic detection of fluorescently labeled synapses in volumetric in vivo imaging data

Molecular Drivers of RNA Phase Separation

Posted by dbos UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Marc Turner, Sarah Robinson-Schwartz, Siavash Fazel Darbandi, John L.R. Rubenstein and Vikaas Singh Sohal | Summary: RNA molecules are essential in orchestrating the assembly of biomolecular condensates and membraneless compartments in cells. Many condensates form via the association of RNA with proteins containing specific RNA binding motifs. However, […]


Continue.. Molecular Drivers of RNA Phase Separation

Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion

Posted by dbos Hopkins

Kavli Affiliate: Alex Kolodkin | Authors: Sriram Sudarsanam, Luis Guzman-Clavel, Nyle Dar, Jakub Ziak, Naseer Shahid, Xinyu O Jin and Alex L Kolodkin | Summary: Cortical connectivity is contingent on ordered emergence of neuron subtypes followed by the formation of subtype-specific axon projections. Intracortical circuits, including long-range callosal projections, are crucial for information processing, but […]


Continue.. Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion

Loss of the autism associated gene Tbr1 disrupts prediction and encoding by prefrontal ensembles during socioemotional behaviors

Posted by dbos Hopkins

Kavli Affiliate: John Rubenstein and Vikaas Sohal | Authors: Marc Turner, Sarah Robinson-Schwartz, Siavash Fazel Darbandi, John L.R. Rubenstein and Vikaas Singh Sohal | Summary: Disruptions in many genes linked to autism spectrum disorder (ASD) affect synaptic function and socioemotional behaviors in mice. However, exactly how synaptic dysfunction alters neural activity patterns underlying behavior remains […]


Continue.. Loss of the autism associated gene Tbr1 disrupts prediction and encoding by prefrontal ensembles during socioemotional behaviors