Kavli Affiliate: Scott Small | Authors: Clara T Rehmann, Scott T Small, Peter L Ralph and Andrew D. Kern | Summary: As organisms adapt to environmental changes, natural selection modifies the frequency of non-neutral alleles. For beneficial mutations, the outcome of this process may be a selective sweep, in which an allele rapidly increases in […]
Kavli Affiliate: Edward Chang | Authors: Elisabetta Furlanis, Min Dai, Brenda Leyva Garcia, Josselyn Vergara, Ana Pereira, Kenneth Pelkey, Thien Tran, Bram L. Gorissen, Anna Vlacho, Ariel Hairston, Shuhan Huang, Deepanjali Dwivedi, Sarah Du, Sara Wills, Justin McMahon, Anthony T. Lee, Edward F. Chang, Taha Razzaq, Ahmed Qazi, Geoffrey Vargish, Xiaoqing Yuan, Adam Caccavano, Steven […]
Kavli Affiliate: Terrence Sejnowski | Authors: Matthew Hur, Thomas Bartol, Padmini Rangamani, Terrence Sejnowski and Eric Mjolsness | Summary: There is a morphodynamic component to synaptic learning by which changes in dendritic (postsynaptic) spine head size are associated with the strengthening or weakening of the synaptic connection between two neurons, in response to the temporal […]
Kavli Affiliate: Adam S. Charles | Authors: Eva Yezerets, Noga Mudrik and Adam Charles | Summary: Mounting empirical evidence indicates that neural “tuning” can be highly variable within an individual across time and especially across individuals. Furthermore, modulatory effects can change the relationship between neurons in the brain as a function of behavioral or other […]
Kavli Affiliate: Alipasha Vaziri | Authors: Ali Haydaroğlu, Sam Dodgson, Michael Krumin, Andrew Landau, Liad J. Baruchin, Tinya Chang, Jingkun Guo, David Meyer, Charu B. Reddy, Jian Zhong, Na Ji, Sylvia Schröder, Kenneth D. Harris, Alipasha Vaziri and Matteo Carandini | Summary: In two-photon imaging of neuronal activity it is common to acquire 3-dimensional volumes. […]
Kavli Affiliate: Rafael Yuste | Authors: Kengo Takahashi, Gerhardus Jan Huis in ‘t Veld, Davide Benedetti, Jun-Ying Wang, Samuel Pontes Quero, Rafael Yuste, Cyriel M.A. Pennartz and Umberto Olcese | Summary: Many techniques to record and manipulate neuronal activity across large portions of the vertebrate brain, such as widefield and two-photon calcium imaging, electrophysiology, and […]
Kavli Affiliate: Kishore V. Kuchibhotla and Adam S. Charles | Authors: Alejandro A Estrada Berlanga, Gabrielle Kang, Amanda Kwok, Thomas Broggini, Jennifer Lawlor, Kishore Kuchibhotla, David Kleninfeld, Gal Mishne and Adam Charles | Summary: Optical calcium imaging is a powerful tool for recording neural activity across a wide range of spatial scales, from dendrites and […]
Kavli Affiliate: Andrea Hasenstaub | Authors: James Bigelow, Toshiaki Suzuki, Yulang Wu, Ying Hu and Andrea R Hasenstaub | Summary: Recent studies suggest some hippocampal (HC) neurons respond to passively presented sounds in naive subjects, but the specificity and prevalence of these responses remain unclear. We used Neuropixels probes to record unit activity in HC […]
Kavli Affiliate: Kevin Bender | Authors: Elinor Lewis, Jessie Muir, Ling C Li, Julianna Glienke, Sarah Warren Gooding, Kevin Bender, Christina Kim and Jennifer Whistler | Summary: Second generation antipsychotics (SGAs) are widely used clinical tools, yet they often cause negative side effects and take weeks to become effective, leading to poor patient compliance. The […]
Kavli Affiliate: Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Madison M. Walker, Jacopo Razzauti, Anurag Sharma, H. Amalia Pasolli and Leslie B. Vosshall | Summary: Female mosquitoes typically mate once in a lifetime, making this singular mating decision critically important for the female. Yet, mosquito mating has been historically viewed as male-guided, with the female […]