Kavli Affiliate: Mark Ellisman | Authors: Juan I. Ispizua, Micaela Rodriguez-Caron, Francisco J. Tassara, Kim Keun-young, Catalina Insusarry Perkins, Milagros Barzi, Christian Carpio-Romero, Celia N. Hansen, Julian Gargiulo, Ezio Rosato, Horacio de la iglesia, Mark Ellisman and M. Fernanda Ceriani | Summary: In Drosophila, about 250 clock neurons in the brain form a network that […]
Kavli Affiliate: Kenneth Miller | Authors: Peijia Yu, Yuhan Yang, Olivia Gozel, Ian Oldenburg, Mario Dipoppa, Federico Rossi, Kenneth Miller, Hillel Adesnik, Na Ji and Brent Doiron | Summary: In sensory cortex of brain it is often the case that neurons are spatially organized by their functional properties. A hallmark of primary visual cortex (V1) […]
Kavli Affiliate: Peter Walter | Authors: Shiqi Diao, Jia Yi Zou, Shuo Wang, Nour Ghaddar, Jason E. Chan, Hyungdong Kim, Nicolas Poulain, Constantinos Koumenis, Maria Hatzoglou, Peter Walter, Nahum Sonenberg, John Le Quesne, Tuomas Tammela and Antonis E. Koromilas | Summary: The link between the “stress phenotype”-a well-established hallmark of cancer-and its role in tumor […]
Kavli Affiliate: Stefano Fusi | Authors: Lorenzo Posani, Shuqi Wang, Samuel Muscinelli, Liam Paninski and Stefano Fusi | Summary: A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently (“categorical” representations [1–3]) and the implications for neural computation. Here, we systematically analyzed how cortical neurons encode […]
Kavli Affiliate: Pietro De Camilli | Authors: Michael G Hanna, Hely O Rodriguez Cruz, Kenshiro Fujise, Yumei Wu, C Shan Xu, Song Pang, Li Zhuoning, Mara Monetti and Pietro De Camilli | Summary: Recent studies have identified a family of rod-shaped proteins thought to mediate lipid transfer at intracellular membrane contacts by a bridge-like mechanism. […]
Kavli Affiliate: Reza Shadmehr | Authors: Mohammad Amin Fakharian, Alden Shoup, Paul Hage, Hisham Elseweifi and Reza Shadmehr | Summary: Null space theory predicts that a neuron will often generate spikes not to produce behavior, but to prevent another neuron’s impact on behavior. Here, we present a direct test of this theory in the brain. […]
Kavli Affiliate: Kathleen Cullen and Vikram Chib | Authors: Joonhee Leo Lee, Agostina Casamento-Moran, Amy J Bastian, Kathleen E Cullen and Vikram S. Chib | Summary: Goal-directed motor performance relies on the brain’s ability to distinguish between actions that lead to successful and unsuccessful outcomes. The basal ganglia (BG) and cerebellum (CBL) are integral to […]
Kavli Affiliate: Zachary Knight | Authors: James C.R. Grove, Queenie Li, Heiko Backes, Bojana Kuzmanovic, Jaewon Choi, Violeta Ubadiah, Longhui Qiu, Jingkun Zhang, Zhengya Liu, Dana M. Small, Marc Tittgemeyer and Zachary A Knight | Summary: Animals learn about the external world, in part, via interoceptive signals1,2. For example, the nutrient content of food is […]
Kavli Affiliate: Scott Small | Authors: Clara T Rehmann, Scott T Small, Peter L Ralph and Andrew D. Kern | Summary: As organisms adapt to environmental changes, natural selection modifies the frequency of non-neutral alleles. For beneficial mutations, the outcome of this process may be a selective sweep, in which an allele rapidly increases in […]
Kavli Affiliate: Pietro De Camilli | Authors: Anbang Dai, Peng Xu, Chase Amos, Kenshiro Fujise, Yumei Wu, Han Yang, Julia N. Eisen, Andrés Guillén-Samander and Pietro De Camilli | Summary: BLTP2/KIAA0100, a bridge-like lipid transfer protein, was reported to localize at contacts of the endoplasmic reticulum (ER) with either the plasma membrane (PM) or recycling […]