Kavli Affiliate: Adam S. Charles | Authors: Anuththara Rupasinghe, Adam S Charles and Jonathan W Pillow | Summary: Neural variability poses a major challenge to understanding the information content of neural codes. Recent work by Goris et al. (Nat. Neurosci 2014) has provided new insights into variability in the visual pathway by partitioning it into […]
Kavli Affiliate: Jean-Laurent Casanova | Authors: Adam Krebs, Tomi Lazarov, Anthony Reynolds, Kimberly Anne Dill-McFarland, Abigail Xie, James Bean, Muxue Du, Olivier Levy, John Buglino, Aaron Zhong, Anna-Lena Neehus, Stephenie Boisson-Dupuis, Jean-Laurent Casanova, Elouise Elizabeth Kroon, Marlo Moller, Thomas R. Hawn, Ting Zhou, Lydia Finley, Marc-Antoine Jean Juste, Dan Fitzgerald, Frederic Geissmann and Michael S […]
Kavli Affiliate: A. James Hudspeth | Authors: Rohan S Roy and A. J. Hudspeth | Summary: Peripheral nerve regeneration requires precise selection of the appropriate targets of innervation, often in an environment that differs from that during the developmental wiring of the neural circuit. Severed axons of the zebrafish posterior lateral line nerve have the […]
Kavli Affiliate: Darcy Peterka | Authors: Amir Lawen, Isabella K Succi, Daniela Lichtman, Darcy S Peterka, Ishmail J Abdus-Saboor and Itamar Kahn | Summary: Dopaminergic signaling in the nucleus accumbens (NAc) is central to reward-based learning, but its relationship to brain-wide hemodynamics remains unclear. Using concurrent fMRI and dopamine photometry in awake, behaving mice, we […]
Kavli Affiliate: Deanna J. Greene | Authors: Damion V Demeter, Matthew Feigelis, Carolina Badke DAndrea, Sana A Ali, Abigail R Baim, Emily Koithan, Jared Stearns, Salma Zreik, Jonathan Ahern, Sujin Park, Sarah E Chang, Ryland L Miller, Jaqueline M Hampton, Bradley L Schlaggar, Scott Marek, Evan M Gordon, Nico UF Dosenbach, Caterina Gratton and Deanna […]
Kavli Affiliate: Vikaas Sohal | Authors: Shana E Silverstein, Thomas T Clarity, Meena S Deshpande, Erik Vaughan, Shoshana Novik, Hector E Yarur, Shiliang Zhang, Valerie S Tsai, Rong Ye, Rachel M Mikofsky, Madeline Hsiang, Avery Bauman, Gabriel Loewinger, Francisco Pereira, Marisela Morales, Vikaas S Sohal, Hugo Tejeda, Joshua A Gordon and David A Kupferschmidt | […]
Kavli Affiliate: Winrich Freiwald | Authors: Lucas Y Tian, Kedar U Garzón, Adam G Rouse, Mark AG Eldridge, Marc H Schieber, Xiao-Jing Wang, Joshua B Tenenbaum and Winrich A Freiwald | Summary: At the core of intelligence is proficiency in solving new problems, including those that differ dramatically from problems seen before. Problem-solving, in turn, […]
Kavli Affiliate: Reza Shadmehr | Authors: Sritej Padmanabhan, Reza S Shadmehr, Roberta Klatzky and Jonathan S Tsay | Summary: Implicit sensorimotor adaptation—the automatic correction of movement errors through feedback and practice—is driven by a perceptual prediction error, the mismatch between the perceived movement outcome and its intended goal. While perceptual uncertainty is known to attenuate […]
Kavli Affiliate: Stephen Strittmatter | Authors: Azucena Perez-Canamas, Mingming Chen, Leire Almandoz-Gil, Nabab Khan, Si Jie Tang, Allyson Ho, Erik C Gunther and Stephen M. Strittmatter | Summary: Fibrils of misfolded α-synuclein (α-syn) accumulate in Parkinson’s disease and other synucleinopathies, spreading between cells to template further misfolding and drive neurodegeneration. α-syn fibril entry into healthy […]
Kavli Affiliate: Wei Min | Authors: Pei Zhuang, Benjamin Scott, Shuai Gao, Wei-Min Meng, Rui Yin, Xinyu Nie, Ludovica Gaiaschi, Sean E Lawler, Martine LM Lamfers, Fengfeng Bei and Choi-Fong Cho | Summary: The blood-brain barrier (BBB) is a highly specialized system that is critical for regulating transport between the blood and the central nervous […]