Context-specific interaction of the lipid regulator DIP-2 with phospholipid synthesis in axon regeneration and maintenance.

Posted by dbos UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Seungmee Park, Andrew D. Chisholm and Yishi Jin | Summary: Neurons maintain their morphology over prolonged periods of adult life with limited regeneration after injury. C. elegans DIP-2 is a conserved regulator of lipid metabolism that affects axon maintenance and regeneration after injury. Here, we investigated genetic interactions of […]


Continue.. Context-specific interaction of the lipid regulator DIP-2 with phospholipid synthesis in axon regeneration and maintenance.

Evaluation of sequencing reads at scale using rdeval

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Bonhwang Koo, Marco Sollitto, Jennifer Balacco, Nadolina Brajuka, Richard Burhans, Erick Duarte, Alice Maria Giani, Kirsty McCaffrey, Jack A Medico, Eugene W Myers, Patrik Smeds, Anton Nekrutenko and Erich D Jarvis | Summary: Motivation: Large sequencing data sets are produced and deposited into public archives at unprecedented […]


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Optogenetic interrogation of the lateral-line sensory system reveals mechanisms of pattern separation in the zebrafish brain

Posted by dbos Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Nicolas Velez, Sihao Lu, Brian Fabella, Caleb C. Reagor, Holland R Brown, Yuriria Vazquez, Adrian Jacobo and Albert James Hudspeth | Summary: The ability of animals to interact with their environment hinges on the brain’s capacity to distinguish between patterns of sensory information and accurately attribute them to […]


Continue.. Optogenetic interrogation of the lateral-line sensory system reveals mechanisms of pattern separation in the zebrafish brain

Neuronal Silencing and Protection in a Mouse Model of Demyelination

Posted by dbos Columbia

Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Julie Borovicka, Hale Tobin, Shruti Bhatia, Jacob Icardi, Ghazaal Tahmasebi, Priyanka Agochiya, Shriya Singh, Bruce Trapp and Hod Dana | Summary: Damage to the myelin sheath that protects axons in the central nervous system is a hallmark pathology of demyelinating diseases like multiple sclerosis. Cuprizone-induced demyelination in […]


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Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

Posted by dbos UCSD / Salk

Kavli Affiliate: Kathleen Cullen and Vikram Chib | Authors: Jonathan Choy, Shadi Charara, Kalyani Cauwenberghs, Quintyn McKaughan, Keun-Young Kim, Mark Ellisman and Chih-Ying Su | Summary: Dendritic morphology is a defining characteristic of neuronal subtypes. In Drosophila, heterotypic olfactory receptor neurons (ORNs) expressing different receptors display diverse dendritic morphologies, but whether such diversity exists among […]


Continue.. Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

Network Biomarkers of Alzheimer’s Disease Risk Derived from Joint Volume and Texture Covariance Patterns in Mouse Models

Posted by dbos Hopkins

Kavli Affiliate: Joshua Vogelstein | Authors: Eric W Bridgeford, Jaewon Chung, Robert J Anderson, Ali Mahzarnia, Jacques A Stout, Hae Sol Moon, Zay Yar Han, Joshua T Vogelstein and Alexandra Badea | Summary: Alzheimer’s disease (AD) lacks effective cures and is typically detected after substantial pathological changes have occurred, making intervention challenging. Early detection and […]


Continue.. Network Biomarkers of Alzheimer’s Disease Risk Derived from Joint Volume and Texture Covariance Patterns in Mouse Models

A Generalist Intracortical Motor Decoder

Posted by dbos UCSF

Kavli Affiliate: Kristofer Bouchard | Authors: Joel Ye, Fabio Rizzoglio, Adam Smoulder, Hongwei Mao, Xuan Ma, Patrick Marino, Raeed H Chowdhury, Dalton D Moore, Gary Blumenthal, Will Hockeimer, Nicolas G. Kunigk, J Patrick Mayo, Aaron P Batista, Steven M Chase, Adam G Rouse, Michael L. Boninger, Charles Greenspon, Andrew B. Schwartz, Nicholas Hatsopoulos, Lee E […]


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The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

Posted by dbos Rockefeller

Kavli Affiliate: C. David Allis | Authors: Agata Lemiesz Patriotis, Yadira Soto-Feliciano, Douglas Barrows, Laiba Khan, Marylene Leboeuf, Peder Lund, Matthew R Marunde, Annaelle Djomo, Michael-Christopher Keogh, Thomas Carroll, Benjamin Garcia, Alexey A Soshnev and C. David Allis | Summary: Polycomb group proteins maintain gene expression patterns established during early development, with Polycomb Repressive Complex […]


Continue.. The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics

Posted by dbos UCSF

Kavli Affiliate: Michael Keiser | Authors: Parker Grosjean, Kaivalya Shevade, Cuong Nguyen, Sarah Ancheta, Karl Mader, Ivan Franco, Seok-Jin Heo, Greyson Lewis, Steven Boggess, Angelique De Domenico, Erik Ullian, Shawn Shafer, Adam Litterman, Laralynne Przybyla, Michael J Keiser, Jamie Ifkovits, Adam Yala and Martin Kampmann | Summary: High-throughput phenotypic screening has historically relied on manually […]


Continue.. Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics

Separable Dorsal Raphe Dopamine Projections mediate the Facets of Loneliness-like state

Posted by dbos UCSD / Salk

Kavli Affiliate: Kay Tye | Authors: Christopher R Lee, Gillian A Matthews, Mackenzie E Lemieux, Elizabeth M Wasserlein, Matilde Borio, Raymundo L Miranda, Laurel R Keyes, Gates P Schneider, Caroline Jia, Andrea Tran, Faith Aloboudi, May G Chan, Enzo Peroni, Grace Pereira, Alba López-Moraga, Anna Pall é, Eyal Y Kimchi, Nancy Padilla-Coreano, Romy Wichmann and […]


Continue.. Separable Dorsal Raphe Dopamine Projections mediate the Facets of Loneliness-like state