StCEL-based platform enables detection and sequencing of native sialoglycoRNA

Kavli Affiliate: Wei Min | Authors: Guang-Dong Zeng, Yun-Long Wang, Xu-Hui Chen, Yi Ma, Zhu Zhu, Huan-Lei Liu, Li-Yuan Fan, Hao Nan, Ziwaregul Nur, Min Wei, Xin-Yuan Liu, Li Yi, Jiu-Yu Jin, Yu-Song Cao, Meng-Bo Qiu, Wei-Peng Sun, Yang Bai, Quan-Bo Zhou, Guo-Qing Zhang, Jing-Feng Chen, Jie Shi, Jian Zheng, Yixuan Xie, Peng Li, Xiang-Bo […]


Continue.. StCEL-based platform enables detection and sequencing of native sialoglycoRNA

Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation

Kavli Affiliate: Michael Beer | Authors: Jielin Yan, Hyein S. Cho, Renhe Luo, Michael A. Beer, Wei Li and Danwei Huangfu | Summary: Precise regulation of transcription factor (TF) expression is critical for maintaining cell identity, but studies on how graded expression levels affect cellular phenotypes are limited. To address this gap, we employed human […]


Continue.. Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation

CK2 inhibition suppresses glial inflammation in the brain

Kavli Affiliate: Nicola Allen | Authors: Fred H Gage, Ioana I N Da Silva, Desiree Ramirez, Sarah L Parylak, Leslie A Wallace, James K Tucker, Joel M Erberich, Rutvi Katariya, Aidan H McDonald, Iryna S Gallina, Ariana L Tucker, Jillybeth Burgado, Baptiste N Jaeger, Jerika J Barron, Joshua M Pratt, Monique Pena, Vipula Racha, Christina […]


Continue.. CK2 inhibition suppresses glial inflammation in the brain

Protein Structure Informed Bacteriophage Genome Annotation with Phold

Kavli Affiliate: Robert Edwards | Authors: George Bouras, Susanna R Grigson, Milot Mirdita, Michael Heinzinger, Bhavya Papudeshi, Vijini Mallawaarachchi, Renee Green, Rachel Seongeun Kim, Victor Mihalia, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde, Martin Steinegger and Robert A Edwards | Summary: Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for […]


Continue.. Protein Structure Informed Bacteriophage Genome Annotation with Phold

Modeling hidden cognitive states reveals acute and chronic effects of fentanyl on decision-making

Kavli Affiliate: Patricia Janak | Authors: Zhenlong Zhang, Patricia H. Janak and Eric Garr | Summary: The cognitive mechanisms underlying behavior are often dynamic, shifting gradually or abruptly over time scales spanning years, to weeks, to minutes. Whether drug-induced changes in learning and decision-making follow similarly dynamic patterns remains unclear. To address this, we apply […]


Continue.. Modeling hidden cognitive states reveals acute and chronic effects of fentanyl on decision-making

Sequence termination cues drive habits via dopamine-mediated credit assignment

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Yifeng Cheng, Joanna Zhou, Haley Province, Nathalie Thiriet, Patricia H Janak and Youna Vandaele | Summary: Background Mesolimbic dopamine (DA) neurons are central to cue guided reward seeking and action sequence learning. Yet, the mechanisms by which cue-induced DA neural activity drives goal-directed or habitual sequence execution […]


Continue.. Sequence termination cues drive habits via dopamine-mediated credit assignment

Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

Kavli Affiliate: Solomon Snyder | Authors: Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwran Chakraborty, Sunil Jamuna Tripathi, Ryan S Dhindsa, Samaneh Saberi, Julia E Lefler, Priyanka Kothari, Cristina Ricco, Kalyani Chaubey, Adele M Snowman, Michael C Ostrowski, Eugenio Barone, Lakshiminarayan M Iyer, L Aravind, Sudarshana M Sharma, Andrew A Pieper, Bobby Thomas, Solomon H […]


Continue.. Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

Cell Cycle Arrest of a “Zippering” Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders

Kavli Affiliate: Georgia Panagiotakos | Authors: Tiange Qu, Brandon H Chacon, Louis Faure, Marta Losa, Rocio Hernandez-Martinez, Kelsey Robinson, Aragorn Jones, Steven Lisgo, Maurizio Risolino, Jaiden De Anda, Georgia Panagiotakos, Elizabeth J Leslie-Clarkson, Igor Adameyko and Licia Selleri | Summary: Facial features identify individuals, but the mechanisms shaping the human face remain elusive. Orofacial clefting […]


Continue.. Cell Cycle Arrest of a “Zippering” Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders

MAPseq2: a sensitive and cost-effective barcoded connectomics method

Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Huihui Qi, Craig Washington, Xiaoping Liang and Justus M Kebschull | Summary: The barcoded connectomics tool MAPseq enables highly multiplexed projection mapping of individual neurons by translating neuroanatomy into a DNA sequencing problem. Here we present MAPseq2, a user-friendly protocol with 3-4 fold increased barcode detection […]


Continue.. MAPseq2: a sensitive and cost-effective barcoded connectomics method

Heterochromatin-based silencing of a foreign tandem repeat in Drosophila melanogaster shows unusual biochemistry and temperature sensitivity

Kavli Affiliate: Elena Gracheva | Authors: Tingting Gu, Elena Gracheva, Michael Lee, Wilson M Leung, Sophia Bieser, Alixandria Nielsen, Adam T. Smiley, Nhi N.T. Vuong, Matthias Walther, Gunter Reuter, Sarah C.R. Elgin and Andrew M Arsham | Summary: Eukaryotic genomes are packaged into chromatin, a regulatory nucleoprotein assembly. Establishment, maintenance, and interconversion of chromatin states […]


Continue.. Heterochromatin-based silencing of a foreign tandem repeat in Drosophila melanogaster shows unusual biochemistry and temperature sensitivity