Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional phenotypes in Down Syndrome

Posted by klaurent UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: Ashley N Brandebura, Quinn N Asbell, Mariel Kristine B Micael and Nicola J Allen | Summary: Neuronal dendrite structure and synapse formation is tightly regulated during development to promote proper connectivity. Astrocyte-secreted proteins act as guidance and pro-synaptogenic factors, and astrocyte protein secretion is dysregulated in neurodevelopmental disorders with […]


Continue.. Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional phenotypes in Down Syndrome

Using a function-first “scout fragment”-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller, Ekaterina V. Vinogradova | Authors: Jared R Ramsey, Patrick M M Shelton, Tyler K. Heiss, Paul Dominic B Olinares, Lauren E Vostal, Heather Soileau, Michael Grasso, Sara Warrington, Stephanie Adaniya, Michael Miller, Shan Sun, David J Huggins, Robert W Myers, Brian T Chait, Ekaterina V Vinogradova and Tarun M Kapoor | […]


Continue.. Using a function-first “scout fragment”-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes

Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy

Posted by klaurent UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Guillaume A Castillon, Sebastien Phan, Junru Hu, Daniela Boassa, Stephen R Adams and Mark H Ellisman | Summary: The binding and interaction of proteins with nucleic acids such as DNA and RNA constitutes a fundamental biochemical and biophysical process in all living organisms. Identifying and visualizing such temporal interactions […]


Continue.. Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy

Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a tropical multi–host community

Posted by klaurent UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Our understanding of pathogen spillover is largely based on viral systems associated with bats. Bacterial infections of zoonotic origin also pose a significant public health burden, many of which are associated with small […]


Continue.. Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a tropical multi–host community

ImAge: an imaging approach to quantitate aging and rejuvenation

Posted by klaurent UCSD / Salk

Kavli Affiliate: Tatyana Sharpee | Authors: Martin Alvarez-Kuglen, Delany Rodriguez, Haodong Qin, Kenta Ninomiya, Lorenzo Fiengo, Chen Farhy, Aaron Havas, Wei-Mien Hsu, Gen-Sheng Feng, Amanda Roberts, Rozalyn M Anderson, Manuel Serrano, Peter D Adams, Tatyana O Sharpee and Alexey Terskikh | Summary: Biomarkers of biological age that predict the risk of disease and expected lifespan […]


Continue.. ImAge: an imaging approach to quantitate aging and rejuvenation

MCell4 with BioNetGen: A Monte Carlo Simulator of Rule-Based Reaction-Diffusion Systems with Python Interface

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Adam Husar, Mariam Ordyan, Guadalupe C Garcia, Joel G Yancey, Ali S Saglam, James Faeder, Thomas M Bartol, Jr., Mary B Kennedy and Terrence J Sejnowski | Summary: Biochemical signaling pathways in living cells are often highly organized into spatially segregated volumes, membranes, scaffolds, subcellular compartments, and organelles comprising […]


Continue.. MCell4 with BioNetGen: A Monte Carlo Simulator of Rule-Based Reaction-Diffusion Systems with Python Interface

Acetylcholine signaling in the medial prefrontal cortex mediates the ability to learn an active avoidance response following learned helplessness training

Posted by klaurent Yale

Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Yann S Mineur, Richard B Crouse, Ian M Etherington, Hanna Yousuf, Jessica J Na and Marina R Picciotto | Summary: Increased brain levels of acetylcholine (ACh) are observed in subsets of patients with depression and increasing ACh levels chronically can precipitate stress-related behaviors in humans and […]


Continue.. Acetylcholine signaling in the medial prefrontal cortex mediates the ability to learn an active avoidance response following learned helplessness training

Perisaccadic and Attentional Remapping of Receptive Fields in Lateral Intraparietal Area and Frontal Eye Fields

Posted by klaurent Columbia

Kavli Affiliate: Michael Goldberg | Authors: Xiao Wang, Cong Zhang, Lin Yang, Min Jin, Michael E Goldberg, Mingsha Zhang and Ning Qian | Summary: The nature and function of perisaccadic receptive-field (RF) remapping have been controversial. We used a delayed saccade task to reduce previous confounds and examined the remapping time course in areas LIP […]


Continue.. Perisaccadic and Attentional Remapping of Receptive Fields in Lateral Intraparietal Area and Frontal Eye Fields

Automatic monitoring of whole-body neural activity in behaving Hydra

Posted by klaurent Columbia

Kavli Affiliate: Rafael Yuste | Authors: Alison Hanson, Raphael Reme, Noah Telerman, Wataru Yamamoto, Jean-Christophe Olivo-Marin, Thibault Lagache and Rafael Yuste | Summary: The ability to record every spike from every neuron in a behaving animal is one of the holy grails of neuroscience. Here, we report coming one step closer towards this goal with […]


Continue.. Automatic monitoring of whole-body neural activity in behaving Hydra

Predicting Long and Short Duration Beta Bursts from Subthalamic Nucleus Local Field Potential Activity in Parkinson’s Disease

Posted by klaurent UCSF

Kavli Affiliate: Philip Starr | Authors: Bahman Abdi-Sargezeh, Sepehr Shirani, Abhinav Sharma, Philip Starr, Simon Little and Ashwini Oswal | Summary: Neural activities within the beta frequency range (13-30 Hz) are not stationary, but occur in transient packets known as beta bursts. Parkinson’s disease (PD) is characterized by the occurrence of beta bursts of increased […]


Continue.. Predicting Long and Short Duration Beta Bursts from Subthalamic Nucleus Local Field Potential Activity in Parkinson’s Disease