Mapping energy landscapes of homopolymeric RNAs via simulated tempering and deep unsupervised learning

Kavli Affiliate: V. S. Ramachandran | Authors: Vysakh Ramachandran and Davit A Potoyan | Summary: Conformational dynamics plays crucial roles in RNA functions about sensing and responding to environmental signals. The liquid-liquid phase separation of RNAs and the formation of stress granules partly relies on RNA’s conformational plasticity and its ability to engage in multivalent […]


Continue.. Mapping energy landscapes of homopolymeric RNAs via simulated tempering and deep unsupervised learning

Substructure of the brain’s Cingulo-Opercular network

Kavli Affiliate: Deanna J. Greene | Authors: Carolina Badke D’Andrea, Timoth O Laumann, Dillan J Newbold, Steven M Nelson, Ashley N Nielsen, Roselyne Chauvin, Scott Marek, Deanna J. Greene, Nico U F Dosenbach and Evan M Gordon | Summary: HThe Cingulo-Opercular network (CON) is an executive network of the human brain that regulates actions. CON […]


Continue.. Substructure of the brain’s Cingulo-Opercular network

Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Kavli Affiliate: Timothy A. Ryan & Pietro De Camilli | Authors: Talex Kokotos, Aldana Antoniazzi, Santiago Unda, Myung Soo Kokotos, Daehun Park, David Eliezer, Michael Kaplitt, Pietro De Camilli and Timothy Ryan | Summary: Phosphoglycerate kinase 1 (PGK1), the first ATP producing glycolytic enzyme, has emerged as a therapeutic target for Parkinson’s Disease (PD), since […]


Continue.. Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A

Kavli Affiliate: Daniel Mucida | Authors: Gregory P. Donaldson, Gabriella L. Reis, Marwa Saad, Izabela Mamede, Guo Chen, Nicole L. DelGaudio, Dayu Zhang, Begum Aydin, Caroline E. Harrer, Tiago B.R. Castro, Sergei Grivennikov, Bernardo S. Reis, Beth M. Stadtmueller, Gabriel D. Victora and Daniel Mucida | Summary: Immunoglobulin A (IgA) is the most abundant antibody […]


Continue.. Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A

Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting

Kavli Affiliate: Xin Duan | Authors: Axel Guskjolen, Jagroop Dhaliwal, Juan de la Parra, Jonathan R Epp, Sangyoon Ko, Erin Chahley, Mitch de Snoo, Michela Solari, Prabdeep Panesar, Jason Scott Snyder, Xin Duan, Joshua Sanes, Sheena Josselyn and Paul Frankland | Summary: Post-training increases in hippocampal neurogenesis are associated with forgetting of hippocampus-dependent memories in […]


Continue.. Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting

Developmental origin and local signals cooperate to determine septal astrocyte identity

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Yajun Xie, Christopher M Reid, Alejandro A Granados, Miguel Turrero Garcia, Fiona Dale-Huang, Sarah M Hanson, Walter R Mancia Leon, Jonathan Liu, Manal A Adam, Olivia Mosto, Angela Oliveira Pisco, Arturo Alvarez-Buylla and Corey C Harwell | Summary: Astrocyte specification during development is influenced by both intrinsic and extrinsic […]


Continue.. Developmental origin and local signals cooperate to determine septal astrocyte identity

A model of marmoset monkey vocal turn-taking

Kavli Affiliate: Cory Miller | Authors: Dori Grijseels, Daniella Fairbank and Cory Miller | Summary: Vocal turn-taking has been described in a diversity of species. Yet a model that captures the various processes underlying this social behavior across species has not been developed. To this end, here we recorded a large and diverse dataset of […]


Continue.. A model of marmoset monkey vocal turn-taking

Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science

Kavli Affiliate: Laurent Younes & Donald Geman | Authors: Kun Yang, Koko Ishizuka, Andrew P Lane, Zui Narita, Arisa Hayashida, Yukiko Y Lema, Emma Heffron, Haydn Loudd, Maeve Schumacher, Shin-ichi Kano, Toshifumi Tomoda, Atsushi Kamiya, Minghong Ma, Donald Geman, Laurent Younes and Akira Sawa | Summary: Biopsy is crucial in clinical medicine to obtain tissues […]


Continue.. Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science

Cellular Calcium Activity at Depth Predicted from Surface Potential Recordings using Ultra-high Density Transparent Graphene Arrays

Kavli Affiliate: Takaki Komiyama | Authors: Mehrdad Ramezani, Jeong-Hoon Kim, Xin Liu, Chi Ren, Abdullah Alothman, Chawina De- Eknamkul, Madison Wilson, Ertugrul Cubukcu, Vikash Gilja, Takaki Komiyama and Duygu Kuzum | Summary: Recording brain activity with high spatial and high temporal resolution across deeper layers of cortex has been a long-sought methodology to study how […]


Continue.. Cellular Calcium Activity at Depth Predicted from Surface Potential Recordings using Ultra-high Density Transparent Graphene Arrays

Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Kavli Affiliate: Jean Fan | Authors: Rafael dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Lyla Atta, Manjari Anant, Mark A Atkinson, Todd M Brusko, Clive H Wasserfall and Jean Fan | Summary: Spatially resolved omics technologies provide molecular profiling of cells while preserving their organization within tissues, allowing for the evaluation of cell-type […]


Continue.. Characterizing cell-type spatial relationships across length scales in spatially resolved omics data