Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

Kavli Affiliate: Flora Vaccarino | Authors: Yifan Wang, Liana Fasching, Feinan Wu, Anita Huttner, Sabina Berretta, Rosalinda Roberts, James F. Leckman, Alexej Abyzov and Flora M. Vaccarino | Summary: Tourette syndrome (TS) is a disorder of high-order integration of sensory, motor, and cognitive functions afflicting as many as 1 in 150 children and characterized by […]


Continue.. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

Distal tuft dendrites shape and maintain new place fields

Kavli Affiliate: Franck Polleux Attila Losonczy | Authors: Justin K. O’Hare, Jamie Wang, Margjele D. Shala, Franck Polleux and Attila Losonczy | Summary: Hippocampal pyramidal neurons support episodic memory by integrating complementary information streams into new ‘place fields’. Distal tuft dendrites are thought to initiate place field formation via plateau potentials. However, the hitherto experimental […]


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A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Kavli Affiliate: John Serences | Authors: Anna Shafer-Skelton, Timothy F Brady and John T Serences | Summary: Understanding 3D representations of spatial information, particularly in naturalistic scenes, remains a significant challenge in vision science. This is largely because of conceptual difficulties in disentangling higher-level 3D information from co-occurring features and cues (e.g., the 3D shape […]


Continue.. A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

MarmoPose: A Deep Learning-Based System for Real-time Multi-Marmoset 3D Pose Tracking

Kavli Affiliate: Xiaoqin Wang | Authors: Chaoqun Cheng, Zijian Huang, Ruiming Zhang, Guozheng Huang, Han Wang, Likai Tang and Xiaoqin Wang | Summary: The common marmoset has become an important experimental animal model in scientific research. The ability to capture and quantify behaviors of marmosets in natural environment and social scenarios is highly desired by […]


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Solving the where problem in neuroanatomy: a generative framework with learned mappings to register multimodal, incomplete data into a reference brain

Kavli Affiliate: Michael Miller | Authors: Daniel Jacob Tward, Bryson D P Gray, Xu Li, Bingxing Huo, Samik Banerjee, Stephen Savoia, Christopher Mezias, Sukhendu Das, Michael Miller and Partha Pratim Mitra | Summary: A current focus of research in neuroscience is to enumerate, map and annotate neuronal cell types in whole vertebrate brains using different […]


Continue.. Solving the where problem in neuroanatomy: a generative framework with learned mappings to register multimodal, incomplete data into a reference brain

in silico transcriptome dissection of neocortical excitatory neurogenesis via joint matrix decomposition and transfer learning

Kavli Affiliate: Brian Caffo | Authors: Shreyash Sonthalia, Guangyan Li, Xoel Mato Blanco, Alex Casella, Jinrui Liu, Genevieve Stein-O’Brien, Brian Caffo, Shaun Adkins, Joshua Orvis, Ronna Hertzano, Anup Mahurkar, Jesse A Gillis, Jonathan Werner, Shaojie Ma, Nicola Micali, Nenad Sestan, Pasko Rakic, Gabriel Santpere Baro, Seth A Ament and Carlo Colantuoni | Summary: The rising […]


Continue.. in silico transcriptome dissection of neocortical excitatory neurogenesis via joint matrix decomposition and transfer learning

Deep phenotypic profiling of neuroactive drugs in larval zebrafish

Kavli Affiliate: Michael Keiser | Authors: Leo Gendelev, Jack Taylor, Douglas Myers-Turnbull, Steven Chen, Matthew N. McCarroll, Michelle R. Arkin, David Kokel and Michael J. Keiser | Summary: Behavioral larval zebrafish screens leverage a high-throughput small molecule discovery format to find neuroactive molecules relevant to mammalian physiology. We screened a library of 650 central nervous […]


Continue.. Deep phenotypic profiling of neuroactive drugs in larval zebrafish

A series of spontaneously blinking dyes for super-resolution microscopy

Kavli Affiliate: Timothy Brown | Authors: Katie L. Holland, Sarah E. Plutkis, Timothy A. Daugird, Abhishek Sau, Jonathan B. Grimm, Brian P. English, Qinsi Zheng, Sandeep Dave, Fariha Rahman, Liangqi Xie, Peng Dong, Ariana N. Tkachuk, Timothy A. Brown, Robert H. Singer, Zhe J. Liu, Catherine G. Galbraith, Siegfried M. Musser, Wesley R. Legant and […]


Continue.. A series of spontaneously blinking dyes for super-resolution microscopy

Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex

Kavli Affiliate: Anirvan Nandy | Authors: Xize Xu, Mitchell P Morton, Nyomi Hudson, Anirvan Nandy and Monika P. Jadi | Summary: Our visual experience is a result of the concerted activity of neuronal ensembles in the sensory hierarchy. Yet how the spatial organization of objects influences neural activity in this hierarchy remains poorly understood. We […]


Continue.. Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex

The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

Kavli Affiliate: Li Zhao | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sayal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]


Continue.. The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain