Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Kavli Affiliate: Michael Miller | Authors:August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J Travaglini, Mariano Gabitto, Rebecca D Hodge, Eitan Kaplan, Ed Lein, Phillip De Jager, David A Bennett, Eunjung Alice […]


Continue.. Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Long range projections of oxytocin neurons in the marmoset brain

Kavli Affiliate: Cory Miller | Arthur Lefevre, Jazlynn Meza and Cory Miller | Summary: The neurohormone oxytocin (OT) has become a major target for the development of novel therapeutic strategies to treat psychiatric disorders such as autism spectrum disorder because of its integral role in governing many facets of mammalian social behavior. Whereas extensive work […]


Continue.. Long range projections of oxytocin neurons in the marmoset brain

Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex

Kavli Affiliate: Patricia Janak | David J Ottenheimer, Katherine R Vitale, Frederic Ambroggi, Patricia H Janak and Benjamin T Saunders | Summary: Basolateral amygdala (BLA) neuronal responses to conditioned stimuli are closely linked to the expression of conditioned behavior. An area of increasing interest is how the dynamics of BLA neurons relate to evolving behavior. […]


Continue.. Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex

Transforming chemigenetic bimolecular fluorescence complementation systems into chemical dimerizers using chemistry

Kavli Affiliate: Timothy Brown | Pratik Kumar, Alina Gutu, Amelia Waring, Timothy A Brown, Luke D Lavis and Alison G. Tebo | Summary: Chemigenetic tags are versatile labels for fluorescence microscopy that combine some of the advantages of genetically encoded tags with small molecule fluorophores. The Fluorescence Activating and absorbance Shifting Tags (FASTs) bind a […]


Continue.. Transforming chemigenetic bimolecular fluorescence complementation systems into chemical dimerizers using chemistry

Pronounced early differentiation underlies zebra finch gonadal germ cell development

Kavli Affiliate: Erich Jarvis | First 5 Authors: Matthew T Biegler, Kirubel Belay, Wei Wang, Christina Szi, Paul G Collier, Ji-Dung Luo, Bettina Haase, Gregory L. Gedman, Asha V. Sidhu, Elijah Harter, Carlos Rivera-Lopez, Kwame Amoako-Boadu, Olivier Fedrigo, Hagen U. Tilgner, Thomas T Carroll, Erich D. Jarvis and Anna L. Keyte | Summary: The diversity […]


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Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Kavli Affiliate: Dwight Bergles | First 5 Authors: Marc Duque, Alex B. Chen, Eric Hsu, Sujatha Narayan, Altyn Rymbek, Shahinoor Begum, Gesine Saher, Adam Ezra Cohen, David E. Olson, David A Prober, Dwight E Bergles, Mark C Fishman, Florian Engert and Misha B Ahrens | Summary: Mood-altering compounds hold promise for the treatment of many […]


Continue.. Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Effects of parental age and polymer composition on short tandem repeat de novo mutation rates

Kavli Affiliate: Michael Goldberg | Authors: Michael E Goldberg, Michelle D Noyes, Evan E Eichler, Aaron Quinlan and Kelley Harris | Summary: Short tandem repeats (STRs) are hotspots of genomic variability in the human germline because of their high mutation rates, which have long been attributed largely to polymerase slippage during DNA replication. This model […]


Continue.. Effects of parental age and polymer composition on short tandem repeat de novo mutation rates

Homological landscape of human brain functional sub-circuits

Kavli Affiliate: Alan David Kaplan | Authors: Duy Duong-Tran, Ralph Kaufmann, Jiong Chen, Xuan Wang, Sumita Garai, Frederick Xu, Jingxuan Bao, Enrico Amico, Alan David Kaplan, Giovanni Petri, Joaquin Goni, Yize Zhao and Li Shen | Summary: Human whole-brain functional connectivity networks have been shown to exhibit both local/quasilocal (e.g., set of functional sub-circuits induced […]


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Microbial aromatic amino acid metabolism is modifiable in fermented food matrices to promote bioactivity

Kavli Affiliate: Michael Miller | Authors: Mikaela C Kasperek, Adriana Velasquez Galeas, Maria Elisa Caetano-Silva, Zifan Xie, Alexander V Ulanov, Michael R La Frano, Suzanne Devkota, Michael J Miller and Jacob M Allen | Summary: Ingestion of fermented foods impacts human immune function, yet the bioactive food components underlying these effects are not understood. Here, […]


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Neurotrophin NT-4/5 Promotes Structural Changes in Neurons of the Developing Visual Cortex

Kavli Affiliate: Michael Stryker | Authors: Antonella Antonini, Sheri L Harris and Michael P Stryker | Summary: Current hypotheses on the mechanisms underlying the development and plasticity of the ocular dominance system through competitive interactions between pathways serving the two eyes strongly suggest the involvement of neurotrophins and their high affinity receptors. In the cat, […]


Continue.. Neurotrophin NT-4/5 Promotes Structural Changes in Neurons of the Developing Visual Cortex