Recurrent connections enable point attractor dynamics and dimensionality reduction in a connectome-constrained model of the insect learning center

Posted by dbos Hopkins

Kavli Affiliate: Grace Hwang and Kechen Zhang | Authors: Justin Joyce, Raphael Norman-Tenazas, Patricia Rivlin, Grace M. Hwang, Isaac Western, Kechen Zhang, William Gray-Roncal and Brian Robinson | Summary: The learning center in the insect, the mushroom body (MB) with its predominant population of Kenyon Cells (KCs), is a widely studied model system to investigate […]


Continue.. Recurrent connections enable point attractor dynamics and dimensionality reduction in a connectome-constrained model of the insect learning center

EEG responses to rapidly unfolding stochastic sounds reflect precision tracking

Posted by dbos Hopkins

Kavli Affiliate: Mounya Elhilali | Authors: Sijia Zhao, Benjamin Skerritt-Davis, Mounya Elhilali, Frederic Dick and Maria Chait | Summary: The brain is increasingly viewed as a statistical learning machine, where our sensations and decisions arise from the intricate interplay between bottom-up sensory signals and constantly changing expectations regarding the surrounding world. Which statistics does the […]


Continue.. EEG responses to rapidly unfolding stochastic sounds reflect precision tracking

Aberrant Connectivity Across the Lifespan in a Mouse Model of Alzheimer’s disease and Rescue by mGlur5 Modulator Treatment

Posted by dbos Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Xilin Shen, Gabriel Desrosiers-Gregoire, David O’Connor, Bandhan Mukherjee, Ashley Owens, An Qu, John Onofrey, Xenophon Papademetris, Mallar Chakravarty, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Amyloid accumulation in Alzheimer’s disease (AD) is associated with synaptic damage and altered connectivity in brain networks. While measures of […]


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The control of overt and covert attention across two nodes of the attention-control network

Posted by dbos Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Pablo Polosecki, Sara C Steenrod, Heiko Stemmann and Winrich A. Freiwald | Summary: Attention is a central cognitive capability whose focus is thought to be directed by a spatial map coding behavioral priority. Here we tested the three defining properties of priority map theory with electrophysiological recordings from two […]


Continue.. The control of overt and covert attention across two nodes of the attention-control network

A Causal Perspective for Batch Effects: When is no answer better than a wrong answer?

Posted by dbos Hopkins

Kavli Affiliate: Brian Caffo and Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Batch effects, undesirable sources of variance across multiple experiments, present significant challenges for scientific and clinical discoveries. Specifically, batch […]


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The 3-Dimensional Genome Drives the Evolution of Asymmetric Gene Duplicates via Enhancer Capture-Divergence

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Deanna Arsala, Shengqian Xia, Cong Li, Mujahid Ali, Nicolas Svetec, Christopher Langer, Debora Sobreira, Ittai Eres, Dylan Sosa, Jianhai Chen, Li Zhang, Patrick Reilly, Alexander Guzzetta, J.J. Emerson, Peter Andolfatto, Li Zhao and Manyuan Long | Summary: Previous evolutionary models of duplicate gene evolution have overlooked the […]


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Comment on ‘Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation’

Posted by dbos UCSF

Kavli Affiliate: Joshua Berke | Authors: James Taniguchi, Riccardo Melani, Lynne Chantranupong, Michelle J Wen, Ali Mohebi, Joshua D Berke, Bernardo L Sabatini and Nicolas X Tritsch | Summary: Acetylcholine is widely believed to modulate the release of dopamine in the striatum of mammals. Experiments in brain slices clearly show that synchronous activation of striatal […]


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Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors:August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J Travaglini, Mariano Gabitto, Rebecca D Hodge, Eitan Kaplan, Ed Lein, Phillip De Jager, David A Bennett, Eunjung Alice […]


Continue.. Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Long range projections of oxytocin neurons in the marmoset brain

Posted by dbos UCSD / Salk

Kavli Affiliate: Cory Miller | Arthur Lefevre, Jazlynn Meza and Cory Miller | Summary: The neurohormone oxytocin (OT) has become a major target for the development of novel therapeutic strategies to treat psychiatric disorders such as autism spectrum disorder because of its integral role in governing many facets of mammalian social behavior. Whereas extensive work […]


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Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | David J Ottenheimer, Katherine R Vitale, Frederic Ambroggi, Patricia H Janak and Benjamin T Saunders | Summary: Basolateral amygdala (BLA) neuronal responses to conditioned stimuli are closely linked to the expression of conditioned behavior. An area of increasing interest is how the dynamics of BLA neurons relate to evolving behavior. […]


Continue.. Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex