FBM: Freestanding bilayer microscope for single-molecule imaging of membrane proteins

Posted by dbos Rockefeller

Kavli Affiliate: Roderick MacKinnon | Authors: Gonzalo Pérez-Mitta, Yeliz Sezgin, Weiwei Wang and Roderick MacKinnon | Summary: Abstract Integral membrane proteins (IMPs) constitute a large fraction of organismal proteomes, playing fundamental roles in physiology and disease. Despite their importance, the mechanisms underlying dynamic features of IMPs, such as anomalous diffusion, protein-protein interactions, and protein clustering, […]


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An experimental census of retrons for DNA production and genome editing

Posted by dbos UCSF

Kavli Affiliate: Seth Shipman | Authors: Asim G. Khan, Matías Rojas-Montero, Alejandro González-Delgado, Santiago C. Lopez, Rebecca F. Fang and Seth L. Shipman | Summary: Abstract Retrons are bacterial immune systems that use reverse transcribed DNA as a detector of phage infection. They are also increasingly deployed as a component of biotechnology. For genome editing, […]


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Regional specialization manifests in the reliability of neural population codes

Posted by dbos UCSF

Kavli Affiliate: Razi Haque Christoph Kirst Loren Frank | Authors: Kyu Hyun Lee, Eric L. Denovellis, Ryan Ly, Jeremy Magland, Jeff Soules, Alison E Comrie, Daniel P Gramling, Jennifer A Guidera, Rhino Nevers, Philip Adenekan, Chris Brozdowski, Sam Bray, Emily Monroe, Ji Hyun Bak, Michael Coulter, Xulu Sun, Andrew Tritt, Oliver Oliver Ruebel, Thinh Nguyen, […]


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Geometry of anisotropic contextual interactions in the visual cortex places fundamental limits on spatial vision

Posted by klaurent Yale

Kavli Affiliate: Anirvan Nandy | Authors: Mitchell P. Morton, Sachira Denagamage, Nyomi V. Hudson and Anirvan S. Nandy | Summary: Crowding, the impaired ability to accurately recognize a target stimulus among distractors, is a major bottleneck in visual perception. The spatial configuration of distractors in relation to the target profoundly influences perceptual fidelity. Notably, when […]


Continue.. Geometry of anisotropic contextual interactions in the visual cortex places fundamental limits on spatial vision

Dynamic categorization rules alter representations in human visual cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: John Serences | Authors: Margaret M Henderson, John T Serences and Nuttida Rungratsameetaweemana | Summary: Abstract Everyday perceptual tasks require sensory stimuli to be dynamically encoded and analyzed according to changing behavioral goals. For example, when searching for an apple at the supermarket, one might first find the Granny Smith apples by separating […]


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Moving Beyond Processing and Analysis-Related Variation in Neuroscience

Posted by klaurent Hopkins

Kavli Affiliate: Joshua Vogelstein | Authors: Xinhui Li, Nathalia Bianchini Esper, Lei Ai, Steve Giavasis, Hecheng Jin, Eric Feczko, Ting Xu, Jon Clucas, Alexandre Franco, Anibal Solon Heinsfeld, Azeez Adebimpe, Joshua T. Vogelstein, Chao-Gan Yan, Oscar Esteban, Russell A. Poldrack, Cameron Craddock, Damien Fair, Theodore Satterthwaite, Gregory Kiar and Michael P. Milham | Summary: Abstract […]


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Standardised Measurements for Monitoring and Comparing Multiphoton Microscope Systems

Posted by dbos Columbia

Kavli Affiliate: Darcy Peterka | Authors: Robert M. Lees, Isaac H. Bianco, Robert A. A. Campbell, Natalia Orlova, Darcy S. Peterka, Bruno Pichler, Spencer LaVere Smith, Dimitri Yatsenko, Che-Hang Yu and Adam M. Packer | Summary: Abstract The goal of this protocol is to enable better characterisation of multiphoton microscopy hardware across a large user […]


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The combination of feedforward and feedback processing accounts for contextual effects in visual cortex

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Serena Di Santo, Mario Dipoppa, Andreas Keller, Morgane Roth, Massimo Scanziani and Kenneth D Miller | Summary: Abstract Sensory systems must combine local features with context to infer meaning. Accordingly, context profoundly influences neural responses. We developed a unified circuit model demonstrating how feedforward and feedback inputs are integrated […]


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CellBoost: A pipeline for machine assisted annotation in neuroanatomy

Posted by dbos UCSD / Salk

Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, Beth Friedman, Jun Takatoh, Fan Wang, David Kleinfeld and Yoav Freund | Summary: One of the important yet labor intensive tasks in neuroanatomy is the identification of select populations of cells. Current high-throughput techniques enable marking cells with histochemical fluorescent molecules as well as through the genetic […]


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Lecanemab Blocks the Effects of the Aβ/Fibrinogen Complex on Blood Clots and Synapse Toxicity in Organotypic Culture

Posted by dbos Rockefeller

Kavli Affiliate: Sidney Strickland | Authors: Pradeep K Singh, Elisa Nicoloso Simoes-Pires, Zu-Lin Chen, Daniel Torrente, Marissa Calvano, Anurag Sharma, Sidney Strickland and Erin H Norris | Summary: Proteinaceous brain inclusions, neuroinflammation, and vascular dysfunction are common pathologies in Alzheimer’s disease (AD). Vascular deficits include a compromised blood-brain barrier, which can lead to extravasation of […]


Continue.. Lecanemab Blocks the Effects of the Aβ/Fibrinogen Complex on Blood Clots and Synapse Toxicity in Organotypic Culture