Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

Posted by dbos Columbia

Kavli Affiliate: Seth Blackshaw | Authors: Dong Won Kim, Soohyun Kim, Jeong Han, Karan Belday, Emily Li, Nicholas Mahoney, Seth Blackshaw and Fatemeh Rajaii | Summary: Despite recent advances in the treatment of thyroid eye disease (TED), significant gaps remain in our understanding of the underlying molecular mechanisms, particularly concerning the insulin-like growth factor-1 receptor […]


Continue.. Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling

Posted by dbos Rockefeller

Kavli Affiliate: Michael W. Young | Authors: Michael Young, David M Booth, David Smith, Marco Tigano, Gyorgy Hajnoczky and Suresh Joseph | Summary: The activation of IP3 receptor (IP3R) Ca2+ channels generates agonist-mediated Ca2+ signals that regulate a wide range of biological processes. It is therefore surprising that CRISPR induced loss of all three IP3R […]


Continue.. Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling

A Subcortical Feeding Circuit Linking Interoception to Jaw movement

Posted by dbos Rockefeller, UCSF

Kavli Affiliate: Jeffrey M. Friedman and Zachary Knight | Authors: Christin Kosse, Jessica Ivanov, Zachary Knight, Kyle Pellegrino and Jeffrey Friedman | Summary: The brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the neural pathways linking interoceptive inputs to outputs for feeding are poorly understood. Here we delineate […]


Continue.. A Subcortical Feeding Circuit Linking Interoception to Jaw movement

Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Devon E Mason, Megan Goeckel, Sebastian L Vega, Pei-Hsun Wu, Dymonn Johnson, Su-Jin Heo, Denis Wirtz, Jason A Burdick, Levi Wood, Brain Y Chow, Amber N Stratman and Joel D Boerckel | Summary: Vascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. […]


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Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

Posted by dbos Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Agnik Dasgupta, Caleb C. Reagor, Sang Peter Paik, Lauren M Snow, Adrian Jacobo and Albert Hudspeth | Summary: In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory […]


Continue.. Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

A low-resource reliable pipeline to democratize multi-modal connectome estimation and analysis

Posted by dbos Hopkins

Kavli Affiliate: Brian Caffo Randal Burns Carey Priebe Joshua Vogelstein | Authors: Jaewon Chung, Ross Lawrence, Alexander Loftus, Gregory Kiar, Eric Bridgeford, Consortium for Reliability and Reproducibility, Vikram Chandrashekhar, Disa Mhembere, Sephira Ryman, Xi-Nian Zuo, Daniel Margulies, R. Cameron Craddock, Carey E. Priebe, Rex Jung, Vince D. Calhoun, Brian Caffo, Randal Burns, Michael P. Milham […]


Continue.. A low-resource reliable pipeline to democratize multi-modal connectome estimation and analysis

Brain substates induced by DMT relate to sympathetic output and meaningfulness of the experience

Posted by klaurent UCSF

Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Alexander Simon, Courtney Gallen, Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart-Harris and Christopher Timmermann | Summary: N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory […]


Continue.. Brain substates induced by DMT relate to sympathetic output and meaningfulness of the experience

Structure and function of an intermediate GPCR-G protein complex

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Maxine Bi, Xudong Wang, Jinan Wang, JUN xu, Wenkai Sun, Victtor Ayo Adediwrua, Yinglong Miao, Yifan Cheng and Libin Ye | Summary: Despite hundreds of GPCR-Gαβγ complex structures, these snapshots uniquely capture the fully activated complex. Consequently, a comprehensive understanding of the conformational transitions during GPCR activation and the […]


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Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli | Authors: Hanieh Falahati, Yumei Wu and Pietro De Camill | Summary: Abstract The endoplasmic reticulum (ER) is a continuous cellular endomembrane network that displays focal specializations. Most notable examples of such specializations include the spine apparatus of neuronal dendrites, and the cisternal organelle of axonal initial segments. Both organelles […]


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Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Vered Kellner, Patrick Parker, Xuelong Mi, Guoqiang Yu, Gesine Saher and Dwight E Bergles | Summary: Abstract Afferent neurons in developing sensory organs exhibit a prolonged period of burst firing prior to the onset of sensory experience. This intrinsically generated activity propagates from the periphery through central processing centers […]


Continue.. Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain