Kavli Affiliate: Jeremy Willsey | Authors: Nia Teerikorpi, Micaela C Lasser, Sheng Wang, Elina Kostyanovskaya, Ethel Bader, Nawei Sun, Jeanselle Dea, Tomasz J. Nowakowski, A Jeremy Willsey and Helen Willsey | Summary: Autism spectrum disorder (ASD) commonly co-occurs with congenital heart disease (CHD), but the molecular mechanisms underlying this comorbidity remain unknown. Given that children […]
Kavli Affiliate: Marina Picciotto | Authors: Manoela V Fogaca, Fernanda Daher and Marina Picciotto | Summary: Major depressive disorder (MDD) is associated with disruptions in glutamatergic and GABAergic activity in the medial prefrontal cortex (mPFC), leading to altered synaptic formation and function. Low doses of ketamine rapidly rescue these deficits, inducing fast and sustained antidepressant […]
Kavli Affiliate: Tejal Desai | Authors: Darnell L Cuylear, Moyu L Fu, Justin C Chau, Bhushan Kharbikar, Galateia Kazakia, Andrew Jheon, Stefan Habelitz, Sunil D Kapila and Tejal A Desai | Summary: Orthodontic relapse is one of the most prevalent concerns of orthodontic therapy. Relapse results in patients’ teeth reverting towards their pretreatment positions, which […]
Kavli Affiliate: Angela Yu | Authors: Lindsey V Soles, Liang Liu, Xudong Zou, Yoseop Yoon, Shuangyu Li, Lusong Tian, Marielle Valdez, Angela Yu, Hong Yin, Wei Li, Fangyuan Ding, Georg Seelig, Lei Li and Yongsheng Shi | Summary: The RNA exosome plays critical roles in eukaryotic RNA degradation, but it remains unclear how the exosome […]
Kavli Affiliate: Gabriel Silva | Authors: Gabriel Silva Santos, Xianyu Yang, Samuel Gascoigne, Aldo Compagnoni, Andre Dias, Shripad D Tuljapurkar, Maja Kajin and Roberto Salguero-Gomez | Summary: Forecasting responses of natural populations to increasingly stochastic environments is a major challenge in Ecology and Conservation Biology. We now know that populations can modulate how their vital […]
Kavli Affiliate: Philip Starr | Authors: Natalya Slepneva, Genevieve Basich-Pease, Lee Reid, Adam C Frank, Tenzin Norbu, Andrew D Krystal, Leo P Sugrue, Julian C Motzkin, Paul S Larson, Philip A Starr, Melanie A Morrison and A Moses Lee | Summary: Background Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) […]
Kavli Affiliate: Edward Chang | Authors: Ting Qi, Maria Luisa Mandelli, Christa L. Watson Pereira, Emma Wellman, Rian Bogley, Abigail E. Licata, Edward F. Chang, Yulia Oganian and Maria Luisa Gorno-Tempini | Summary: Developmental dyslexia (DD) is typically associated with difficulties in manipulating speech sounds and, sometimes, in basic auditory processing. However, the neuroanatomical correlates […]
Kavli Affiliate: Wei Min | Authors: Ling-Yun Luo, Hui Wu, Li-Ming Zhao, Ya-Hui Zhang, Jia-Hui Huang, Qiu-Yue Liu, Hai-Tao Wang, Dong-Xin Mo, He-Hua EEr, Lian-Quan Zhang, Hai-Liang Chen, Shan-Gang Jia, Wei-Min Wang and Meng-Hua Li | Summary: Ongoing efforts to improve sheep reference genome assemblies still leave many gaps and incomplete regions, resulting in a […]
Kavli Affiliate: Edward Callaway | Authors: Shu-Jing Li, Balazs Hangya, Unmukt Gupta, Kyle B. Fischer, James Fitzhugh Sturgill, Edward M. Callaway and Adam Kepe | Summary: Sustained attention, as an essential cognitive faculty governing selective sensory processing, exhibits remarkable temporal fluctuations. However, the underlying neural circuits and computational mechanisms driving moment-to-moment attention fluctuations remain elusive. […]
Kavli Affiliate: Michael Miller | Authors: Byungjin Lee, Fanny Sunden, Michael Miller, Bumshik Pak, Anke Krebber, Stefan Lutz and Polly M Fordyce | Summary: Engineered enzymes with enhanced or novel functions are specific catalysts with wide-ranging applications in industry and medicine. Here, we introduce Droplet Array Microfluidic Enzyme Kinetics (DA-MEK), a high-throughput enzyme screening platform […]