MarmoPose: A Deep Learning-Based System for Real-time Multi-Marmoset 3D Pose Tracking

Kavli Affiliate: Xiaoqin Wang | Authors: Chaoqun Cheng, Zijian Huang, Ruiming Zhang, Guozheng Huang, Han Wang, Likai Tang and Xiaoqin Wang | Summary: The common marmoset has become an important experimental animal model in scientific research. The ability to capture and quantify behaviors of marmosets in natural environment and social scenarios is highly desired by […]


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Solving the where problem in neuroanatomy: a generative framework with learned mappings to register multimodal, incomplete data into a reference brain

Kavli Affiliate: Michael Miller | Authors: Daniel Jacob Tward, Bryson D P Gray, Xu Li, Bingxing Huo, Samik Banerjee, Stephen Savoia, Christopher Mezias, Sukhendu Das, Michael Miller and Partha Pratim Mitra | Summary: A current focus of research in neuroscience is to enumerate, map and annotate neuronal cell types in whole vertebrate brains using different […]


Continue.. Solving the where problem in neuroanatomy: a generative framework with learned mappings to register multimodal, incomplete data into a reference brain

in silico transcriptome dissection of neocortical excitatory neurogenesis via joint matrix decomposition and transfer learning

Kavli Affiliate: Brian Caffo | Authors: Shreyash Sonthalia, Guangyan Li, Xoel Mato Blanco, Alex Casella, Jinrui Liu, Genevieve Stein-O’Brien, Brian Caffo, Shaun Adkins, Joshua Orvis, Ronna Hertzano, Anup Mahurkar, Jesse A Gillis, Jonathan Werner, Shaojie Ma, Nicola Micali, Nenad Sestan, Pasko Rakic, Gabriel Santpere Baro, Seth A Ament and Carlo Colantuoni | Summary: The rising […]


Continue.. in silico transcriptome dissection of neocortical excitatory neurogenesis via joint matrix decomposition and transfer learning

Deep phenotypic profiling of neuroactive drugs in larval zebrafish

Kavli Affiliate: Michael Keiser | Authors: Leo Gendelev, Jack Taylor, Douglas Myers-Turnbull, Steven Chen, Matthew N. McCarroll, Michelle R. Arkin, David Kokel and Michael J. Keiser | Summary: Behavioral larval zebrafish screens leverage a high-throughput small molecule discovery format to find neuroactive molecules relevant to mammalian physiology. We screened a library of 650 central nervous […]


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A series of spontaneously blinking dyes for super-resolution microscopy

Kavli Affiliate: Timothy Brown | Authors: Katie L. Holland, Sarah E. Plutkis, Timothy A. Daugird, Abhishek Sau, Jonathan B. Grimm, Brian P. English, Qinsi Zheng, Sandeep Dave, Fariha Rahman, Liangqi Xie, Peng Dong, Ariana N. Tkachuk, Timothy A. Brown, Robert H. Singer, Zhe J. Liu, Catherine G. Galbraith, Siegfried M. Musser, Wesley R. Legant and […]


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Spatial context non-uniformly modulates inter-laminar communication in the primary visual cortex

Kavli Affiliate: Anirvan Nandy | Authors: Xize Xu, Mitchell P Morton, Nyomi Hudson, Anirvan Nandy and Monika P. Jadi | Summary: Our visual experience is a result of the concerted activity of neuronal ensembles in the sensory hierarchy. Yet how the spatial organization of objects influences neural activity in this hierarchy remains poorly understood. We […]


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The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

Kavli Affiliate: Li Zhao | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sayal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]


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The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions

Kavli Affiliate: Li Zhao | Authors: Junhui Peng, Nicolas Svetec, Henrik Molina and Li Zhao | Summary: Post-mating responses play a vital role in successful reproduction across diverse species. In fruit flies, sex peptide (SP) binds to sex peptide receptor (SPR), triggering a series of post-mating responses. However, the origin of SPR predates the emergence […]


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Rejuvenating silicon probes for acute electrophysiology

Kavli Affiliate: Reza Shadmehr | Authors: Alden Shoup, Natasha Porwal, Mohammad Amin Fakharian, Paul Hage, Simon P Orozco and Reza Shadmehr | Summary: Electrophysiological recording with a new probe often yields better signal quality than with a used probe. Why does the signal quality degrade after only a few experiments? Here, we considered silicon probes […]


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Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease

Kavli Affiliate: Alexandra Nelson | Authors: Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar and Alexandra B Nelson | Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination is […]


Continue.. Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease