Kavli Affiliate: Kathleen Cullen and Vikram Chib | Authors: Joonhee Leo Lee, Agostina Casamento-Moran, Amy J Bastian, Kathleen E Cullen and Vikram S. Chib | Summary: Goal-directed motor performance relies on the brain’s ability to distinguish between actions that lead to successful and unsuccessful outcomes. The basal ganglia (BG) and cerebellum (CBL) are integral to […]
Kavli Affiliate: Zachary Knight | Authors: James C.R. Grove, Queenie Li, Heiko Backes, Bojana Kuzmanovic, Jaewon Choi, Violeta Ubadiah, Longhui Qiu, Jingkun Zhang, Zhengya Liu, Dana M. Small, Marc Tittgemeyer and Zachary A Knight | Summary: Animals learn about the external world, in part, via interoceptive signals1,2. For example, the nutrient content of food is […]
Kavli Affiliate: Scott Small | Authors: Clara T Rehmann, Scott T Small, Peter L Ralph and Andrew D. Kern | Summary: As organisms adapt to environmental changes, natural selection modifies the frequency of non-neutral alleles. For beneficial mutations, the outcome of this process may be a selective sweep, in which an allele rapidly increases in […]
Kavli Affiliate: Pietro De Camilli | Authors: Anbang Dai, Peng Xu, Chase Amos, Kenshiro Fujise, Yumei Wu, Han Yang, Julia N. Eisen, Andrés Guillén-Samander and Pietro De Camilli | Summary: BLTP2/KIAA0100, a bridge-like lipid transfer protein, was reported to localize at contacts of the endoplasmic reticulum (ER) with either the plasma membrane (PM) or recycling […]
Kavli Affiliate: Takaki Komiyama | Authors: Sonja Blumenstock, David Arakelyan, Nicholas del Grosso, Sonja Schneider, Yufeng Shao, Enida Gjoni, Ruediger Klein, Irina Dudanova and Takaki Komiyama | Summary: Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral […]
Kavli Affiliate: Anders Dale | Authors: Xueying Chen, Hao Wang, Iris Broce, Anders M Dale, Bing Yu, Laura Y Zhou, Xihao Li, Maria Argos, Martha L Daviglus, Jianwen Cai, Nora Franceschini and Tamar Sofer | Summary: Hispanic/Latino populations are admixed, with genetic contributions from multiple ancestral populations. Studies of genetic association in these admixed populations […]
Kavli Affiliate: Yishi Jin | Authors: Seungmee Park, Andrew D. Chisholm and Yishi Jin | Summary: Neurons maintain their morphology over prolonged periods of adult life with limited regeneration after injury. C. elegans DIP-2 is a conserved regulator of lipid metabolism that affects axon maintenance and regeneration after injury. Here, we investigated genetic interactions of […]
Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Bonhwang Koo, Marco Sollitto, Jennifer Balacco, Nadolina Brajuka, Richard Burhans, Erick Duarte, Alice Maria Giani, Kirsty McCaffrey, Jack A Medico, Eugene W Myers, Patrik Smeds, Anton Nekrutenko and Erich D Jarvis | Summary: Motivation: Large sequencing data sets are produced and deposited into public archives at unprecedented […]
Kavli Affiliate: A. James Hudspeth | Authors: Nicolas Velez, Sihao Lu, Brian Fabella, Caleb C. Reagor, Holland R Brown, Yuriria Vazquez, Adrian Jacobo and Albert James Hudspeth | Summary: The ability of animals to interact with their environment hinges on the brain’s capacity to distinguish between patterns of sensory information and accurately attribute them to […]
Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Julie Borovicka, Hale Tobin, Shruti Bhatia, Jacob Icardi, Ghazaal Tahmasebi, Priyanka Agochiya, Shriya Singh, Bruce Trapp and Hod Dana | Summary: Damage to the myelin sheath that protects axons in the central nervous system is a hallmark pathology of demyelinating diseases like multiple sclerosis. Cuprizone-induced demyelination in […]