Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Richard Huganir, Adam S. Charles and Michael Miller | Authors: Shashwat Kumar, Gabrielle I Coste, Dasun Premathilaka, Richard L. Huganir, Austin R Graves, Adam S Charles and Michael I Miller | Summary: Synapses are the fundamental unit of neural connectivity. […]
Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Elizabeth Hillman | Authors: Mary Claire Tuohy, Ping-Chang Kuo, Adrian Chelminski, Eti Muharremi, Claudia DeSantis, Aomeng Cui, Alicia Russo, Danny Jamoul, Elizabeth Hillman, John F Crary, Jui-Hung Jimmy Yen and Dritan Agalliu | Summary: Vascular normalization [stabilization of aberrant angiogenesis […]
Kavli Affiliate: Sarah Woolley | Authors: Isabella Catalano and Sarah Cushing Woolley | Summary: Interacting in a multimodal world, including recognizing other individuals across multiple sensory modalities, is important for animals who rely on social relationships for survival. Social and sensory experiences shape how multisensory information is processed and integrated; however, we have less understanding […]
Kavli Affiliate: Nicola Allen | Authors: Krissy A Lyon, Adrien Paumier, Ananya Kandikonda, Andrea Melendez and Nicola J Allen | Summary: During typical neurodevelopment, astrocytes secrete proteins that support neuronal connectivity. This process is disrupted in Rett Syndrome (RTT), a regressive neurodevelopmental disorder characterized by motor, sensory, and cognitive impairments. While astrocytes typically promote neuron […]
Kavli Affiliate: James Knierim | Authors: Ravikrishnan P Jayakumar, Yotaro Sueoka, Marissa K Ferreyros, Brian Y Li, Manu S Madhav, Xingyu Chen, James J Knierim and Noah J Cowan | Summary: Accurate spatial navigation relies on path integration, a process of tracking one’s location by integrating self-motion cues. Path integration uses a gain factor relating […]
Kavli Affiliate: Edward Chang and Loren Frank | Authors: Yitzhak Norman, Loren M. Frank and Edward F. Chang | Summary: Fluent speech depends on precisely timed motor commands that coordinate rapid transitions between successive articulatory gestures. Using direct cortical recordings, we identified a prominent sensorimotor theta oscillation (6–10 Hz) that supports this coordination. During articulation, […]
Kavli Affiliate: Jeremy Nathans | Authors: Yanshu Wang, Amir Rattner, Zhongming Li, Philip M Smallwood and Jeremy Nathans | Summary: In mice, postnatal endothelial cell (EC)-specific knockout of the genes coding for Transforming Growth Factor-Beta Receptor (TGFBR)1 and/or TGFBR2 eliminates TGF-beta signaling in vascular ECs and leads to distinctive central nervous system (CNS) vascular phenotypes. […]
Kavli Affiliate: Zachary Knight | Authors: Brooke C Jarvie, Anagh Ravi, Rhea Nanavati, Longhui Qui, Truong Ly, Jun Y Oh, Olivia K Barnhill and Zachary A Knight | Summary: Calcitonin Gene-Related Peptide (CGRP) neurons in the parabrachial nucleus are critical for sickness and malaise but have also been proposed to control non-aversive (rewarding) satiation. How […]
Kavli Affiliate: Xin Duan | Authors: Daniela Santamaria-Munoz, Raenier V. Reyes, Miranda R. Krueger, Andrea Garcia-Llorca, Brennan Marsh-Armstrong, Xin Duan, Yang Hu, Derek S. Welsbie, Nicholas Marsh-Armstrong, Elisenda Sanz, Albert Quintana, Sergi Simo and Anna La Torre | Summary: Mitochondrial dysfunction is a central hallmark of many optic neuropathies, yet the mechanisms linking intrinsic metabolic […]
Kavli Affiliate: Li Zhao | Authors: Qing Zhao, William de Nardo, Ruoyu Wang, Yi Zhong, Umur Keles, Gabriele Sakalauskaite, Li Na Zhao, Huiyi Tay, Sonia Youhanna, Mengchao Yan, Ye Xie, Youngrae Kim, Sungdong Lee, Rachel Liyu Lim, Guoshou Teo, Pradeep Naraya, Paul R Burton, Volker M Lauschke, Hyungwon Choi, Matthew J Watt and Philipp Kaldis […]