Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington’s disease

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Matthew Baffuto, Kert Mätlik, Isaac Ilyashov, Maria Esterlita Siantoputri, Hasnahana Chetia, Yurie Harada, Erika Sipos, Paul Darnell, Laura Kus, Thomas Carroll, Douglas Barrows, Christina Pressl, Nicholas Didkovsky and Nathaniel Heintz | Summary: Huntington’s disease (HD) is characterized by neuronal dysfunction and degeneration that varies markedly by brain region and […]


Continue.. Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington’s disease

Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Youssef E Sibih, Abraham O Dada, Emily E Cunningham, Niels Olshausen, Jasleen Kaur, Velmurugan Jayabal, Sena Oten, Sanjeev Herr, Cesar N Gonzales, Andy Daniel, Saritha Krishna, Vardhaan S Ambati, Alexander A Aabedi, Gray Umbach, Kanish Mirchia, Poortata Lalwani, Edward F Chang, David R Raleigh, Srikantan Nagarajan, David Brang and […]


Continue.. Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation

Hebb’s Vision: The Structural Underpinnings of Hebbian Assemblie

Posted by dbos UCSF

Kavli Affiliate: Reza Abbasi Asl | Authors: Julian A Wagner-Carena, Sai Kate, Trevor Riordan, Reza Abbasi-Asl, Joe Aman, Adam Amster, Agnes L Bodor, Derrick Brittain, JoAnn Buchanan, Michael A Buice, Daniel J Bumbarger, Forrest Collman, Nuno Macarico da Costa, Daniel J Denman, Saskia EJ de Vries, Emily Joyce, Dan Kapner, Chase W King, Josh D […]


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GABAergic signaling by VIP interneurons gates running-dependent visual recovery in the adult brain

Posted by dbos UCSF

Kavli Affiliate: Michael Stryker | Authors: Anna Lebedeva, Friedrich Kling, Benjamin Rakela, Michael P Stryker and Yujiao Jennifer Sun | Summary: Experience-dependent plasticity in the adult visual cortex is enhanced by locomotion, a process mediated by vasoactive intestinal peptide (VIP)-expressing interneurons. While VIP interneurons are known to signal through both Gamma-aminobutyric acid (GABA) and VIP […]


Continue.. GABAergic signaling by VIP interneurons gates running-dependent visual recovery in the adult brain

Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: P Monroe Butler, Anna Francis, Angela L Meunier, Amirah K Anderson, Elizabeth L Hennessey, Michael B Miller, Cynthia A Lemere, Dennis J Selkoe and Andrew M Stern | Summary: Importance Anti-amyloid immunotherapy is used to treat Alzheimer disease (AD) with moderate benefits and potentially serious side effects due to […]


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Shared and distinct cortical mechanisms for working memory and decision-making.

Posted by dbos Hopkins

Kavli Affiliate: Daeyeol Lee | Authors: Hyojung Seo, Daeyeol Lee and Shanna K Murray | Summary: The dorsolateral prefrontal cortex (DLPFC) and lateral intraparietal cortex (LIP) in the primate brain are critically involved in working memory during tasks that require the retention of information over a delay. These same regions have also been implicated in […]


Continue.. Shared and distinct cortical mechanisms for working memory and decision-making.

Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Posted by dbos UCSF

Kavli Affiliate: Alexandra Nelson | Authors: Rodrigo M Paz, Michael B Ryan, Pamela F Marcott, Allison E Girasole, Joseph Faryean, Vincent Duong, Sadhana Sridhar and Alexandra B Nelson | Summary: The use of levodopa to manage Parkinson’s disease (PD) symptoms leads to levodopa-induced dyskinesia (LID) and other motor fluctuations, which worsen with disease progression and […]


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Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Maria Luisa Amaral, Sainath Mamde, Michael Miller, Xiaomeng Hou, Jessica Arzavala, Julia Osteen, Elizabeth Walker Smoot, Qian Yang, Emily Eisner, Qiurui Zeng, Cindy Tatiana Baez-Becerra, Jacqueline Olness, Joseph Colin Kern, Jonathan Rink, Nicholas Johnson, Ariana Barcoma, Silvia Cho, Stella Cao, Nora Emerson, Jasper Lee, Jackson Willier, Timothy Loe, Henry […]


Continue.. Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Heather Shappell, Zhiyuan Liu, Mohammadreza Khodaei, George He, Dylan Gee, Martin Lindquist, Denis G. Sukhodolsky, Gregory McCarthy and Karim Ibrahim | Summary: Background Childhood disruptive behavior problems are linked to aberrant integrity within large-scale cognitive control networks. However, it is unclear if transitory or dynamic variation in the functional […]


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Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

Posted by dbos UCSF

Kavli Affiliate: Hana El-Samad | Authors: Achal Mahajan, Francesca Ratti, Ban Wang, Hana El-Samad, James H. Kaufman and Vishrawas Gopalakrishnan | Summary: Regulation of gene expression is fundamental for proper cellular function, and is constrained by the local chromatin environment of each gene, which varies spatially along the chromosome and is shaped by epigenetic modifications. […]


Continue.. Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease