Suite3D: Volumetric cell detection for two-photon microscopy

Kavli Affiliate: Alipasha Vaziri | Authors: Ali Haydaroğlu, Sam Dodgson, Michael Krumin, Andrew Landau, Liad J. Baruchin, Tinya Chang, Jingkun Guo, David Meyer, Charu B. Reddy, Jian Zhong, Na Ji, Sylvia Schröder, Kenneth D. Harris, Alipasha Vaziri and Matteo Carandini | Summary: In two-photon imaging of neuronal activity it is common to acquire 3-dimensional volumes. […]


Continue.. Suite3D: Volumetric cell detection for two-photon microscopy

A polymeric, PDMS-based large-scale skull replacement suitable for optical and mechanical access for long-term neuronal imaging, electrophysiology, and optogenetics

Kavli Affiliate: Rafael Yuste | Authors: Kengo Takahashi, Gerhardus Jan Huis in ‘t Veld, Davide Benedetti, Jun-Ying Wang, Samuel Pontes Quero, Rafael Yuste, Cyriel M.A. Pennartz and Umberto Olcese | Summary: Many techniques to record and manipulate neuronal activity across large portions of the vertebrate brain, such as widefield and two-photon calcium imaging, electrophysiology, and […]


Continue.. A polymeric, PDMS-based large-scale skull replacement suitable for optical and mechanical access for long-term neuronal imaging, electrophysiology, and optogenetics

Fast and accessible morphology-free functional fluorescence imaging analysis

Kavli Affiliate: Kishore V. Kuchibhotla and Adam S. Charles | Authors: Alejandro A Estrada Berlanga, Gabrielle Kang, Amanda Kwok, Thomas Broggini, Jennifer Lawlor, Kishore Kuchibhotla, David Kleninfeld, Gal Mishne and Adam Charles | Summary: Optical calcium imaging is a powerful tool for recording neural activity across a wide range of spatial scales, from dendrites and […]


Continue.. Fast and accessible morphology-free functional fluorescence imaging analysis

Survey of hippocampal responses to sound in naive mice reveals widespread activation by broadband noise onsets

Kavli Affiliate: Andrea Hasenstaub | Authors: James Bigelow, Toshiaki Suzuki, Yulang Wu, Ying Hu and Andrea R Hasenstaub | Summary: Recent studies suggest some hippocampal (HC) neurons respond to passively presented sounds in naive subjects, but the specificity and prevalence of these responses remain unclear. We used Neuropixels probes to record unit activity in HC […]


Continue.. Survey of hippocampal responses to sound in naive mice reveals widespread activation by broadband noise onsets

D3 dopamine receptors implicate a subtype of medium spiny neuron in the aversive effects of antipsychotic medications

Kavli Affiliate: Kevin Bender | Authors: Elinor Lewis, Jessie Muir, Ling C Li, Julianna Glienke, Sarah Warren Gooding, Kevin Bender, Christina Kim and Jennifer Whistler | Summary: Second generation antipsychotics (SGAs) are widely used clinical tools, yet they often cause negative side effects and take weeks to become effective, leading to poor patient compliance. The […]


Continue.. D3 dopamine receptors implicate a subtype of medium spiny neuron in the aversive effects of antipsychotic medications

Mosquito sex under lock and key

Kavli Affiliate: Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Madison M. Walker, Jacopo Razzauti, Anurag Sharma, H. Amalia Pasolli and Leslie B. Vosshall | Summary: Female mosquitoes typically mate once in a lifetime, making this singular mating decision critically important for the female. Yet, mosquito mating has been historically viewed as male-guided, with the female […]


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ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis

Kavli Affiliate: Pietro De Camilli | Authors: Devin M Fuller, Yumei Wu, Florian Schueder, Burha Rasool, Shanta Nag, Justin L. Korfhage, Rolando Garcia-Milian, Katerina D Melnyk, Joerg Bewersdorf, Pietro De Camilli and Thomas Melia | Summary: Autophagosomes form from seed membranes that expand through bulk-lipid transport via the bridge-like lipid transporter ATG2. The origins of […]


Continue.. ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis

Seasonal brain regeneration and chromosome instability are linked to selection on DNA repair in Sorex araneus

Kavli Affiliate: Erich Jarvis | Authors: William R Thomas, Tanya M Lama, Diana Moreno-Santillan, Marta Farre, Cecilia Baldoni, Linelle Abueg, Jennifer Balacco, Olivier Fedrigo, Giulio Formenti, Nivesh Jain, Jacquelyn Mountcastle, Tatiana Tilley, Alan Tracey, David A Ray, Dina K. N. Dechmann, Dominik von Elverfeldt, John Nieland, Angelique P Corthals, Erich Jarvis and Liliana M Davalos […]


Continue.. Seasonal brain regeneration and chromosome instability are linked to selection on DNA repair in Sorex araneus

Hippocampus facilitates reinforcement learning under partial observability

Kavli Affiliate: Rui Costa | Authors: Dabal Pedamonti, Samia Mohinta, Martin Dimitrov, Hugo Malagon-Vina, Stephane Ciocchi and Rui Ponte Costa | Summary: Mastering navigation in environments with limited visibility is crucial for survival. Although the hippocam-pus has been associated with goal-oriented navigation, its role in real-world behaviour remains unclear. To investigate this, we combined deep […]


Continue.. Hippocampus facilitates reinforcement learning under partial observability

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Kavli Affiliate: Seth Shipman Eiman Azim | Authors: Abdulkadir Ozkan, Hari K Padmanabhan, Seth Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, Nazli Basak and Jeffrey D Macklis | Summary: Corticospinal neurons (CSN) centrally degenerate in amyotrophic lateral sclerosis (ALS), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (SCI) […]


Continue.. Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors