Missing data approaches for longitudinal neuroimaging research: Examples from the Adolescent Brain and Cognitive Development (ABCD) Study

Posted by dbos UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Lin Li, Mohammadreza Bayat, Timothy Hayes, Wesley K. Thompson, Arianna Morgan Sandmark Gard and Anthony Steven Dick | Summary: This paper addresses the challenges of managing missing values within expansive longitudinal neuroimaging datasets, using the specific example of data derived from the Adolescent Brain and Cognitive Development ABCD study. […]


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Data-driven fine-grained region discovery in the mouse brain with transformers

Posted by dbos UCSF

Kavli Affiliate: Reza Abbasi Asl | Authors: Alex Jihun Lee, Shenqin Yao, Nicholas Lusk, Hongkui Zeng, Bosiljka Tasic and Reza Abbasi-Asl | Summary: Technologies such as spatial transcriptomics offer unique opportunities to define the spatial organization of the mouse brain. We developed an unsupervised training scheme and novel transformer-based deep learning architecture to detect spatial […]


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Variable recruitment of distal tuft dendrites shapes new hippocampal place fields

Posted by dbos Columbia

Kavli Affiliate: Attila Losonczy and Franck Polleux | Authors: Justin K. O’Hare, Jamie Wang, Margjele D. Shala, Franck Polleux and Attila Losonczy | Summary: Hippocampal pyramidal neurons support episodic memory by integrating complementary information streams into new ‘place fields’. Distal tuft dendrites are widely thought to initiate place field formation by locally generating prolonged, globally-spreading […]


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A feedforward mechanism for human-like contour integration

Posted by dbos Harvard

Kavli Affiliate: George A. Alvarez | Authors: Nathan Wu, Baohua Zhou, Margarida Agrochao and Damon A Clark | Summary: Our intuition suggests that when a movie is played in reverse, our perception of motion in the reversed movie will be perfectly inverted compared to the original. This intuition is also reflected in many classical theoretical […]


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Functional connectome through the human life span

Posted by klaurent Hopkins

Kavli Affiliate: Xiaoqin Wang | Authors: Lianglong Sun, Tengda Zhao, Xinyuan Liang, Mingrui Xia, Qiongling Li, Xuhong Liao, Gaolang Gong, Qian Wang, Chenxuan Pang, Qian Yu, Yanchao Bi, Pindong Chen, Rui Chen, Yuan Chen, Taolin Chen, Jingliang Cheng, Yuqi Cheng, Zaixu Cui, Zhengjia Dai, Yao Deng, Yuyin Ding, Qi Dong, Dingna Duan, Jia-Hong Gao, Qiyong […]


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Broken time reversal symmetry in visual motion detection

Posted by dbos Yale

Kavli Affiliate: Damon Clark | Authors: Nathan Wu, Baohua Zhou, Margarida Agrochao and Damon A Clark | Summary: Our intuition suggests that when a movie is played in reverse, our perception of motion in the reversed movie will be perfectly inverted compared to the original. This intuition is also reflected in many classical theoretical and […]


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Spatial Single-cell Analysis Decodes Cortical Layer and Area Specification

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Xuyu Qian, Kyle Coleman, Shunzhou Jiang, Andrea J Kriz, Jack H Marciano, Chunyu Luo, Chunhui Cai, Monica D Manam, Emre Caglayan, Aoi Otani, Urmi Ghosh, Diane D Shao, Rebecca E Andersen, Jennifer E Neil, Robert Johnson, Alexandra LeFevre, Jonathan L Hecht, Michael B Miller, Liang Sun, Carsen Stringer, Mingyao […]


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Hypothalamic CRH Neurons Modulate Sevoflurane Anesthesia and The Post-anesthesia Stress Responses

Posted by klaurent Columbia

Kavli Affiliate: Wei Min | Authors: Shan Jiang, Lu Chen, Wei-Min Qu, Zhi-Li Huang and Chang-Rui Chen | Summary: General anesthesia is a fundamental process required to undertake safely and humanely a high fraction of surgeries and invasive diagnostic procedures. However, the undesired stress response associated with general anesthesia (GA) causes delayed recovery and even […]


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Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons

Posted by dbos Rockefeller

Kavli Affiliate: Timothy A. Ryan; | Authors: Kirsten Bredvik, Charmaine Liu and Timothy A. Ryan | Summary: The ketogenic diet is an effective treatment for drug-resistant epilepsy, but the therapeutic mechanisms are poorly understood. Although ketones are able to fuel the brain, it is not known whether ketones are directly metabolized by neurons on a […]


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Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli; | Authors: Xinbo Wang, Peng Xu, Amanda Bentley-DeSousa, William Hancock-Cerutti, Shujun Cai, Benjamin T Johnson, Francesca Tonelli, Gabriel Talaia, Dario R Alessi, Shawn M Ferguson and Pietro De Camilli | Summary: Based on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in Parkinson’s disease (PD). Here we […]


Continue.. Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C