A nuclear RNA degradation code for eukaryotic transcriptome surveillance

Kavli Affiliate: Angela Yu | Authors: Lindsey V Soles, Liang Liu, Xudong Zou, Yoseop Yoon, Shuangyu Li, Lusong Tian, Marielle Valdez, Angela Yu, Hong Yin, Wei Li, Fangyuan Ding, Georg Seelig, Lei Li and Yongsheng Shi | Summary: The RNA exosome plays critical roles in eukaryotic RNA degradation, but it remains unclear how the exosome […]


Continue.. A nuclear RNA degradation code for eukaryotic transcriptome surveillance

Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity

Kavli Affiliate: Gabriel Silva | Authors: Gabriel Silva Santos, Xianyu Yang, Samuel Gascoigne, Aldo Compagnoni, Andre Dias, Shripad D Tuljapurkar, Maja Kajin and Roberto Salguero-Gomez | Summary: Forecasting responses of natural populations to increasingly stochastic environments is a major challenge in Ecology and Conservation Biology. We now know that populations can modulate how their vital […]


Continue.. Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity

Therapeutic DBS for OCD Suppresses the Default Mode Network

Kavli Affiliate: Philip Starr | Authors: Natalya Slepneva, Genevieve Basich-Pease, Lee Reid, Adam C Frank, Tenzin Norbu, Andrew D Krystal, Leo P Sugrue, Julian C Motzkin, Paul S Larson, Philip A Starr, Melanie A Morrison and A Moses Lee | Summary: Background Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) […]


Continue.. Therapeutic DBS for OCD Suppresses the Default Mode Network

Anatomical and behavioral correlates of auditory perception in developmental dyslexia

Kavli Affiliate: Edward Chang | Authors: Ting Qi, Maria Luisa Mandelli, Christa L. Watson Pereira, Emma Wellman, Rian Bogley, Abigail E. Licata, Edward F. Chang, Yulia Oganian and Maria Luisa Gorno-Tempini | Summary: Developmental dyslexia (DD) is typically associated with difficulties in manipulating speech sounds and, sometimes, in basic auditory processing. However, the neuroanatomical correlates […]


Continue.. Anatomical and behavioral correlates of auditory perception in developmental dyslexia

Telomere-to-telomere sheep genome assembly reveals new variants associated with wool fineness trait

Kavli Affiliate: Wei Min | Authors: Ling-Yun Luo, Hui Wu, Li-Ming Zhao, Ya-Hui Zhang, Jia-Hui Huang, Qiu-Yue Liu, Hai-Tao Wang, Dong-Xin Mo, He-Hua EEr, Lian-Quan Zhang, Hai-Liang Chen, Shan-Gang Jia, Wei-Min Wang and Meng-Hua Li | Summary: Ongoing efforts to improve sheep reference genome assemblies still leave many gaps and incomplete regions, resulting in a […]


Continue.. Telomere-to-telomere sheep genome assembly reveals new variants associated with wool fineness trait

A disinhibitory basal forebrain to cortex projection supports sustained attention

Kavli Affiliate: Edward Callaway | Authors: Shu-Jing Li, Balazs Hangya, Unmukt Gupta, Kyle B. Fischer, James Fitzhugh Sturgill, Edward M. Callaway and Adam Kepe | Summary: Sustained attention, as an essential cognitive faculty governing selective sensory processing, exhibits remarkable temporal fluctuations. However, the underlying neural circuits and computational mechanisms driving moment-to-moment attention fluctuations remain elusive. […]


Continue.. A disinhibitory basal forebrain to cortex projection supports sustained attention

Hydrophilic/ Omniphobic droplet arrays for high-throughput and quantitative enzymology

Kavli Affiliate: Michael Miller | Authors: Byungjin Lee, Fanny Sunden, Michael Miller, Bumshik Pak, Anke Krebber, Stefan Lutz and Polly M Fordyce | Summary: Engineered enzymes with enhanced or novel functions are specific catalysts with wide-ranging applications in industry and medicine. Here, we introduce Droplet Array Microfluidic Enzyme Kinetics (DA-MEK), a high-throughput enzyme screening platform […]


Continue.. Hydrophilic/ Omniphobic droplet arrays for high-throughput and quantitative enzymology

Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene

Kavli Affiliate: Keri Martinowich | Authors: Genevieve E Craig, Lizbeth Ramos, Samuel R Essig, Nicholas J Eagles, Andrew E Jaffe, Keri Martinowich and Henry L Hallock | Summary: Deficits in attention are common across a range of neuropsychiatric disorders. A multitude of brain regions, including the frontal cortex (FC) and locus coeruleus (LC), have been […]


Continue.. Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene

G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastoma

Kavli Affiliate: Mary E. Hatten | Authors: Danielle L. Keahi, Mathijs A. Sanders, Matthew R. Paul, Andrew L.H. Webster, Yin Fang, Tom F. Wiley, Samer Shalaby, Thomas S. Carroll, Settara C. Chandrasekharappa, Carolina Sandoval-Garcia, Margaret L. MacMillan, John E. Wagner, Mary E. Hatten and Agata Smogorzewska | Summary: Biallelic pathogenic variants in the essential DNA […]


Continue.. G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastoma

Decoding contextual influences on auditory perception from primary auditory cortex

Kavli Affiliate: Mounya Elhilali | Authors: Bernhard Englitz, Sahar Akram, Mounya Elhilali and Shihab Shamma | Summary: SPerception can be highly dependent on stimulus context, but whether and how sensory areas encode the context remains uncertain. We used an ambiguous auditory stimulus – a tritone pair – to investigate the neural activity associated with a […]


Continue.. Decoding contextual influences on auditory perception from primary auditory cortex