JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish

Kavli Affiliate: Seth Blackshaw | Authors: Leah J Elias, Harrison Khoo, Francois Kroll, Caroline Zhang, Soojung C Hur, Jason Rihel and Seth Blackshaw | Summary: While sleep deprivation broadly disrupts health and well-being, the neural and molecular mechanisms that signal increased sleep pressure remain poorly understood. A key obstacle to progress is the fact that […]


Continue.. JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish

Fly navigational responses to odor motion and gradient cues are tuned to plume statistics

Kavli Affiliate: Damon Clark | Authors: Samuel Brudner, Baohua Zhou, Viraaj Jayaram, Gustavo Madeira Santana, Damon Clark and Thierry Emonet | Summary: Odor cues guide animals to food and mates. Different environmental conditions can create differently patterned odor plumes, making navigation more challenging. Prior work has shown that animals turn upwind when they detect odor […]


Continue.. Fly navigational responses to odor motion and gradient cues are tuned to plume statistics

Accelerated Discovery of Cell Migration Regulators Using Label-Free Deep Learning-Based Automated Tracking

Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: Cell migration plays a key role in normal developmental programs and in disease, including immune responses, tissue repair, and metastasis. Unlike other cell functions, such as proliferation which can be studied using high-throughput assays, cell migration […]


Continue.. Accelerated Discovery of Cell Migration Regulators Using Label-Free Deep Learning-Based Automated Tracking

Aging reduces excitatory bandwidth, alters spectral tuning curve diversity, and reduces sideband inhibition in L2/3 of primary auditory cortex

Kavli Affiliate: Patrick Kanold | Authors: Kate Maximov and Patrick O. Kanold | Summary: Presbycusis, or age-related hearing loss, is caused by changes in both the peripheral and the central auditory system. Many of the peripheral structures that degrade with age have been identified and characterized, but there is still a dearth of information pertaining […]


Continue.. Aging reduces excitatory bandwidth, alters spectral tuning curve diversity, and reduces sideband inhibition in L2/3 of primary auditory cortex

Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling

Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe binding to […]


Continue.. Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling

Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

Kavli Affiliate: Kevin Bender | Authors: Joshua D Garcia, Chenyu Wang, Ryan Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George, Roy Ben-Shalom, David H Hackos and Kevin J Bender | Summary: Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized […]


Continue.. Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Jiayao Wang, Bovey Y Rao, Jonathan Chang, Joseph Gogos, Attila Losonczy and Dennis Vitkup | Summary: Neuropsychiatric disorders such as autism spectrum disorder (ASD) and schizophrenia (SCZ) share genetic risk factors, including rare high penetrance single nucleotide variants and copy number variants (CNVs), and exhibit both […]


Continue.. Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

Glutamate indicators with increased sensitivity and tailored deactivation rates

Kavli Affiliate: David Kleinfeld | Authors: Abhi Aggarwal, Adrian Negrean, Yang Chen, Rishyashring Iyer, Daniel Reep, Anyi Liu, Anirudh Palutla, Michael E Xie, Bryan MacLennan, Kenta M Hagihara, Lucas W Kinsey, Julianna L Sun, Pantong Yao, Jihong Zheng, Arthur Tsang, Getahun Tsegaye, Yonghai Zhang, Ronak H Patel, Benjamin J Arthur, Julien Hiblot, Philipp Leippe, Miroslaw […]


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Temporal and Spatial Scales of Resting-state Human Cortical Activity Throughout Lifespan

Kavli Affiliate: Daeyeol Lee | Authors: John Bero IV, Colin Humphries, Yang Li, Aviral Kumar, Heungyeol Lee, Maxwell Shinn, John D. Murray, Timothy Vickery and Daeyeol Lee | Summary: Sensorimotor and cognitive abilities undergo substantial changes throughout the human lifespan, but the corresponding changes in the functional properties of cortical networks remain poorly understood. This […]


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Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

Kavli Affiliate: Ann McDermott | Authors: Chengming He, Nikhil R Varghese, Eric G Keeler, Chi L L Pham, Brayden Williams, Stephan Tetter, Crystal Semaan, Karyn L Wilde, Simon H J Brown, James C Bouwer, Yann Gambin, Emma Sierecki, Megan Steain, Margaret Sunde and Ann E McDermott | Summary: The formation of RIP-homotypic interaction motif (RHIM)-based […]


Continue.. Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR