Nucleoprotein phase-separation affinities revealed via atomistic simulations of short peptide and RNA fragments

Posted by dbos UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Vysakh Ramachandran, William Brown and Davit A Potoyan | Summary: Liquid-liquid phase separation of proteins and nucleic acids into condensate phases is a versatile mechanism for ensuring compartmentalization of cellular biochemistry. RNA molecules play critical roles in these condensates, particularly in transcriptional regulation and stress responses, exhibiting a […]


Continue.. Nucleoprotein phase-separation affinities revealed via atomistic simulations of short peptide and RNA fragments

Oxytocin receptor controls distinct components of pair bonding and development in prairie voles

Posted by dbos UCSF

Kavli Affiliate: Devanand Manoli and Jeremy Willsey | Authors: Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt, Belinda Wang, Gina Williams, Shuyu Wang, Kara Quine, Rose D. Larios, Kimberly L. P. Long, Nerissa Hoglen, Bibi Alika Sulaman, Marie C. Heath, Michael Sherman, Matthew Kinkel, Angela Cai, Denis Galo, Lizandro Chan Caamal, Nastacia L. Goodwin, Annaliese Beery, […]


Continue.. Oxytocin receptor controls distinct components of pair bonding and development in prairie voles

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Posted by dbos UCSF

Kavli Affiliate: Michael Keiser | Authors: Sina Ghandian, Liane Albarghouthi, Kiana Nava, Shivam R. Rai Sharma, Lise Minaud, Laurel Beckett, Naomi Saito, Charles DeCarli, Robert A. Rissman, Andrew F. Teich, Lee-Way Jin, Brittany N. Dugger and Michael J. Keiser | Summary: Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of […]


Continue.. Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Disparate demographic impacts of the Roman Colonization and the Migration Period in the Iberian Peninsula

Posted by dbos UCSD / Salk

Kavli Affiliate: Jose Ricardo Suarez | Authors: Pablo Carrion, Inigo Olalde, Juan Manuel Jimenez-Arenas, Neus Coromina, David Vivo, Josep Maria Verges, Ana Costa, Daniel Botella, Macarena Bustamante-Alvarez, Javier Heras-Mora, Ricardo Ortega-Ruiz, Celia Chaves, Maite Iris Garcia-Collado, Juan Quiros-Castillo, Jordi Roig, Jose Suarez-Padilla, Ildelfonso Navarro-Luengo, Miguel Angel Cuadrado, Isidro Aguilera, Jordi Morera, Raul Catalan, Maria Luisa […]


Continue.. Disparate demographic impacts of the Roman Colonization and the Migration Period in the Iberian Peninsula

A feedforward mechanism for human-like contour integration

Posted by dbos Harvard

Kavli Affiliate: George A. Alvarez | Authors: Fenil R. Doshi, Talia Konkle and George A. Alvarez | Summary: Summary: Deep neural network models provide a powerful experimental platform for exploring core mechanisms underlying human visual perception, such as perceptual grouping and contour integration — the process of linking local edge elements to arrive at a […]


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Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Juthi Biswas, Dilruba Akter, Michael J Miller, Dennis J Thiele, Eain A. Murphy, Christine O’Connor, Jennifer F Moffat and Gary Chan | Summary: Summary: FDA-approved antivirals against HCMV have several limitations, including only targeting the later stages of the viral replication cycle, adverse side effects, and the emergence of […]


Continue.. Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo

Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands

Posted by dbos UCSF

Kavli Affiliate: Joshua Berke and Loren Frank | Authors: Alison E. Comrie, Emily J. Monroe, Ari E. Kahn, Eric L. Denovellis, Abhilasha Joshi, Jennifer A. Guidera, Timothy A. Krausz, Joshua D. Berke, Nathaniel D. Daw and Loren M. Frank | Summary: Summary: The cognitive ability to go beyond the present to consider alternative possibilities, including […]


Continue.. Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands

High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes

Posted by dbos UCSD / Salk

Kavli Affiliate: Edward Callaway | Authors: Li Alex Zhang, Peichao Li and Edward M. Callaway | Summary: Summary: Laminar electrode arrays allow simultaneous recording of activity of many cortical neurons and assignment to layers using current source density (CSD) analyses. Electrode arrays with 100-micron contact spacing have been used to estimate borders between layer 4 […]


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The HIV-1 Nuclear Export Complex Reveals the Role of RNA in Crm1 Cargo Recognition

Posted by dbos UCSF

Kavli Affiliate: Keri Martinowich | Authors: Amber M Smith, Yang Li, Arianna Velarde, Yifan Cheng and Alan D. Frankel | Summary: Summary: Crm1 is a highly conserved nuclear exportin that transports >1000 human proteins including ribonucleoprotein (RNP) complexes. The interface between Crm1 and RNP cargos is unknown. The HIV regulatory protein, Rev, was one of […]


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Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Robert A Phillips III, Seyun Oh, Svitlana V Bach, Yufeng Du, Ryan A Miller, Joel E Kleinman, Thomas M Hyde, Stephanie C Hicks, Stephanie Cerceo Page and Keri Martinowich | Summary: The lateral septum (LS) is a midline, subcortical structure, which regulates social behaviors that are frequently impaired in […]


Continue.. Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species