Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Kavli Affiliate: Michael Miller | Authors: Gannon A. McDonough, Yuchen Cheng, Katherine Morillo, Ryan N. Doan, Connor J. Kenny, Aaron Foutz, Chae Kim, Mark L. Cohen, Brian S. Appleby, Christopher A. Walsh, Jiri G. Safar, August Yue Huang and Michael B. Miller | Summary: Creutzfeldt-Jakob Disease (CJD), the most common human prion disease, is associated […]


Continue.. Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest.

Kavli Affiliate: Denis Wirtz | Authors: Francesco Neri, Shuyuan Zheng, Mark Watson, Pierre Yves Desprez, Akos Gerencser, Judith Campisi, Denis Wirtz, Pei-Hsun Wu and Birgit Schilling | Summary: Cellular senescence has been strongly linked to aging and age-related diseases. It is well established that the phenotype of senescent cells is highly heterogeneous and influenced by […]


Continue.. Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest.

A multimodal fMRI dataset unifying naturalistic processes with a rich array of experimental tasks

Kavli Affiliate: Martin Lindquist | Authors: Heejung Jung, Maryam Amini, Bethany J Hunt, Eilis I Murphy, Patrick Sadil, Yaroslav O Halchenko, Bogdan Petre, Zizhuang Miao, Philip A Kragel, Xiaochun Han, Mickela O Heilicher, Michael Sun, Owen G Collins, Martin A Lindquist and Tor D Wager | Summary: Cognitive neuroscience has advanced significantly due to the […]


Continue.. A multimodal fMRI dataset unifying naturalistic processes with a rich array of experimental tasks

Ancient midbrain inhibitory neurons control selective spatial attention

Kavli Affiliate: Shreesh P. Mysore | Authors: Ninad B Kothari, Wen-Kai You, Arunima Banerjee, Qingcheng Zhang and Shreesh P Mysore | Summary: Animal behavior at any instant is guided by information from only a subset of the plethora of stimuli in their sensory environments. The neural circuit mechanisms that select a behaviorally relevant ‘target’ from […]


Continue.. Ancient midbrain inhibitory neurons control selective spatial attention

Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward

Kavli Affiliate: Keri Martinowich | Authors: Kasey L Brida, Emily T Jorgensen, Robert A Phillips III, Catherine E Newman, Jennifer J Tuscher, Emily K Morring, Morgan E Zipperly, Lara Ianov, Kelsey D Montgomery, Madhavi Tippani, Thomas M Hyde, Kristen R Maynard, Keri Martinowich and Jeremy J Day | Summary: Drugs of abuse activate defined neuronal […]


Continue.. Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward

Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

Kavli Affiliate: Patrick Kanold | Authors: HiJee Kang, Travis Babola and Patrick O Kanold | Summary: Sensory information is represented by small neuronal ensembles in sensory cortices. Neuronal activity shows high trial-by-trial variability in that repeated presentation of the same stimulus, e. g., multiple presentations of the same sound activate differing ensembles in the auditory […]


Continue.. Rapid rebalancing of co-tuned ensemble activity in the auditory cortex

The value of initiating a pursuit in temporal decision-making

Kavli Affiliate: Marshall Hussain Shuler | Authors: Elissa Sutlief, Charlie Walters, Tanya Marton and Marshall G Hussain Shuler | Summary: Reward rate maximization is a prominent normative principle commonly held in behavioral ecology, neuroscience, economics, and artificial intelligence. Here, we identify and compare equations for evaluating the worth of initiating pursuits that an agent could […]


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Network nature of ligand-receptor interactions underlies disease comorbidity in the brain

Kavli Affiliate: Keri Martinowich | Authors: Melissa Grant-Peters, Aine Fairbrother-Browne, Amy Hicks, Boyi Guo, Regina H. Reynolds, Louise A. Huuki-Myers, Nick Eagles, Jonathan Brenton, Sonia Garcia-Ruiz, Nicholas Wood, Sonia Gandhi, Keri Martinowich, Kristen Maynard, Leonardo Collado-Torres and Mina Ryten | Summary: Neurodegenerative disorders have overlapping symptoms and have high comorbidity rates, but this is not […]


Continue.. Network nature of ligand-receptor interactions underlies disease comorbidity in the brain

Functional connectome through the human life span

Kavli Affiliate: Xiaoqin Wang | Authors: Lianglong Sun, Tengda Zhao, Xinyuan Liang, Mingrui Xia, Qiongling Li, Xuhong Liao, Gaolang Gong, Qian Wang, Chenxuan Pang, Qian Yu, Yanchao Bi, Pindong Chen, Rui Chen, Yuan Chen, Taolin Chen, Jingliang Cheng, Yuqi Cheng, Zaixu Cui, Zhengjia Dai, Yao Deng, Yuyin Ding, Qi Dong, Dingna Duan, Jia-Hong Gao, Qiyong […]


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Spatial Single-cell Analysis Decodes Cortical Layer and Area Specification

Kavli Affiliate: Michael Miller | Authors: Xuyu Qian, Kyle Coleman, Shunzhou Jiang, Andrea J Kriz, Jack H Marciano, Chunyu Luo, Chunhui Cai, Monica D Manam, Emre Caglayan, Aoi Otani, Urmi Ghosh, Diane D Shao, Rebecca E Andersen, Jennifer E Neil, Robert Johnson, Alexandra LeFevre, Jonathan L Hecht, Michael B Miller, Liang Sun, Carsen Stringer, Mingyao […]


Continue.. Spatial Single-cell Analysis Decodes Cortical Layer and Area Specification