Kavli Affiliate: Loyal Goff | Authors: Multi-sample non-negative spatial factorization | Summary: It is important to model biological variation when analyzing spatial transcriptomics data from multiple samples. One approach to multi-sample analysis is to spatially align samples, but this is a challenging problem. Here, we provide an alignment-free framework for generalizing a one-sample spatial factorization […]
Kavli Affiliate: Martin Lindquist | Authors: Patrick Sadil and Martin A Lindquist | Summary: Subcortical volumes are a promising source of biomarkers and features in biosignatures, and automated methods facilitate extracting them in large, phenotypically rich datasets. However, while extensive research has verified that the automated methods produce volumes that are similar to those generated […]
Kavli Affiliate: Michael Miller | Authors: Gannon A. McDonough, Yuchen Cheng, Katherine Morillo, Ryan N. Doan, Connor J. Kenny, Aaron Foutz, Chae Kim, Mark L. Cohen, Brian S. Appleby, Christopher A. Walsh, Jiri G. Safar, August Yue Huang and Michael B. Miller | Summary: Creutzfeldt-Jakob Disease (CJD), the most common human prion disease, is associated […]
Kavli Affiliate: Denis Wirtz | Authors: Francesco Neri, Shuyuan Zheng, Mark Watson, Pierre Yves Desprez, Akos Gerencser, Judith Campisi, Denis Wirtz, Pei-Hsun Wu and Birgit Schilling | Summary: Cellular senescence has been strongly linked to aging and age-related diseases. It is well established that the phenotype of senescent cells is highly heterogeneous and influenced by […]
Kavli Affiliate: Martin Lindquist | Authors: Heejung Jung, Maryam Amini, Bethany J Hunt, Eilis I Murphy, Patrick Sadil, Yaroslav O Halchenko, Bogdan Petre, Zizhuang Miao, Philip A Kragel, Xiaochun Han, Mickela O Heilicher, Michael Sun, Owen G Collins, Martin A Lindquist and Tor D Wager | Summary: Cognitive neuroscience has advanced significantly due to the […]
Kavli Affiliate: Shreesh P. Mysore | Authors: Ninad B Kothari, Wen-Kai You, Arunima Banerjee, Qingcheng Zhang and Shreesh P Mysore | Summary: Animal behavior at any instant is guided by information from only a subset of the plethora of stimuli in their sensory environments. The neural circuit mechanisms that select a behaviorally relevant ‘target’ from […]
Kavli Affiliate: Keri Martinowich | Authors: Kasey L Brida, Emily T Jorgensen, Robert A Phillips III, Catherine E Newman, Jennifer J Tuscher, Emily K Morring, Morgan E Zipperly, Lara Ianov, Kelsey D Montgomery, Madhavi Tippani, Thomas M Hyde, Kristen R Maynard, Keri Martinowich and Jeremy J Day | Summary: Drugs of abuse activate defined neuronal […]
Kavli Affiliate: Patrick Kanold | Authors: HiJee Kang, Travis Babola and Patrick O Kanold | Summary: Sensory information is represented by small neuronal ensembles in sensory cortices. Neuronal activity shows high trial-by-trial variability in that repeated presentation of the same stimulus, e. g., multiple presentations of the same sound activate differing ensembles in the auditory […]
Kavli Affiliate: Marshall Hussain Shuler | Authors: Elissa Sutlief, Charlie Walters, Tanya Marton and Marshall G Hussain Shuler | Summary: Reward rate maximization is a prominent normative principle commonly held in behavioral ecology, neuroscience, economics, and artificial intelligence. Here, we identify and compare equations for evaluating the worth of initiating pursuits that an agent could […]
Kavli Affiliate: Keri Martinowich | Authors: Melissa Grant-Peters, Aine Fairbrother-Browne, Amy Hicks, Boyi Guo, Regina H. Reynolds, Louise A. Huuki-Myers, Nick Eagles, Jonathan Brenton, Sonia Garcia-Ruiz, Nicholas Wood, Sonia Gandhi, Keri Martinowich, Kristen Maynard, Leonardo Collado-Torres and Mina Ryten | Summary: Neurodegenerative disorders have overlapping symptoms and have high comorbidity rates, but this is not […]