Cell type-specific barcoding reveals the single-cell projectional architecture of the mouse midbrain dopaminergic system

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Cheng Xu, Craig Washington, Caleb Shi, Maggie Lowman and Justus M Kebschull | Summary: Brain-wide neural circuits are formed by the diverse axonal branching patterns of neurons of different cell types. Here we […]


Continue.. Cell type-specific barcoding reveals the single-cell projectional architecture of the mouse midbrain dopaminergic system

MAPseq2: a sensitive and cost-effective barcoded connectomics method

Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Huihui Qi, Craig Washington, Xiaoping Liang and Justus M Kebschull | Summary: The barcoded connectomics tool MAPseq enables highly multiplexed projection mapping of individual neurons by translating neuroanatomy into a format solvable by DNA sequencing. Here we present MAPseq2, a user-friendly protocol with up to ∼10-fold […]


Continue.. MAPseq2: a sensitive and cost-effective barcoded connectomics method

Functional genomics reveals mediators of beta cell survival in ER stress and type 2 diabetes risk

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Michael Miller | Authors: Mei-Lin Okino, Han Zhu, Sierra Corban, Paola Benaglio, Jovina Djulamsah, Bailey OMahony, Kennedy Vanderstel, Ruth Elgamal, Michael Miller, Allen Wang, Maike Sander and Kyle J Gaulton | Summary: Endoplasmic reticulum (ER) stress in pancreatic beta cells […]


Continue.. Functional genomics reveals mediators of beta cell survival in ER stress and type 2 diabetes risk

Eye-head coordination during goal-directed orienting in mice

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Kathleen Cullen | Authors: Brandie Morris Verdone, Hui Ho Vanessa Chang, Dale C Roberts and Kathleen E Cullen | Summary: In afoveate species such as mice, it is accepted that gaze is typically redirected by head movements with a saccade-and-fixate […]


Continue.. Eye-head coordination during goal-directed orienting in mice

Dynamic coupling between visual landmark processing in area 29e and parahippocampal path integration circuits of the rodent cortex

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: James Knierim | Authors: Gorkem Secer, Bharath Krishnan, Noah Cowan and James J Knierim | Summary: External landmarks anchor internal spatial representations. The neural mechanisms underlying this process and the sources of landmark signals remain unknown. We recorded neurons across […]


Continue.. Dynamic coupling between visual landmark processing in area 29e and parahippocampal path integration circuits of the rodent cortex

Transformations of cognitive maps for sensorimotor control

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Vikram Chib | Authors: Joonhee Leo Lee, Yixuan Wang, Agostina Casamento-Moran, Kosisochukwu Ugorji, Jose Jarquin, Daniel C McNamee and Vikram S Chib | Summary: Adaptive embodied behavior involves transforming structured knowledge about the relationship between environment and action into motor […]


Continue.. Transformations of cognitive maps for sensorimotor control

Acceleration and Velocity Dissociate Temporal Phases of Postural Control in Rhesus Macaques

Kavli Affiliate: Kathleen Cullen | Authors: Olivia M. E. Leavitt Brown, Bassil A Ramadan and Kathleen E Cullen | Summary: Maintaining balance requires the nervous system to transform sensory signals about unexpected postural perturbations into precisely timed motor commands. Although human studies have established that postural responses unfold in distinct temporal phases, how specific kinematic […]


Continue.. Acceleration and Velocity Dissociate Temporal Phases of Postural Control in Rhesus Macaques

Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium

Kavli Affiliate: Michael Miller | Authors: MoTrPAC Study Group, Daniel H. Katz, Christopher A. Jin, Gina M. Many, Gregory R. Smith, Hasmik Keshishian, Natalie M. Clark, Gayatri Iyer, Cheehoon Ahn, Malene E. Lindholm, Tyler J. Sagendorf, David Amar, Jacob L. Barber, Anna R. Brandt, Paul M. Coen, Yongchao Ge, Patrick Hart, Fang-Chi Hsu, Byron C. […]


Continue.. Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium

Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Denis Wirtz | Authors: Jin Liu, Yuanxuan Xia, Brian Mog, Colin Gliech, Elana Shaw, Dylan Ferris, Brock Moritz, Tolulope Awosika, Sarah DiNapoli, Stephanie Glavaris, Kyle J Kaeo, Yang Li, Nikita Marcou, Alexander H Pearlman, Taha Ahmedna, Regina Bugrovsky, Ignacio Sanz, […]


Continue.. Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells

Somatic mosaicism in amyotrophic lateral sclerosis and frontotemporal dementia identifies focal mutations associated with widespread degeneration

Kavli Affiliate: Michael Miller | Authors: Zinan Zhou, Junho Kim, August Yue Huang, Matthew Nolan, Junseok Park, Ryan Doan, Taehwan Shin, Michael B Miller, Mingyun Bae, Boxun Zhao, Jinhyeong Kim, Brian Chhouk, Katherine Morillo, Rebecca C Yeh, Connor Kenny, Jennifer E Neil, Chao-Zong Lee, Takuya Ohkubo, John Ravits, Olaf Ansorge, Lyle W Ostrow, Clotilde Lagier-Tourenne, […]


Continue.. Somatic mosaicism in amyotrophic lateral sclerosis and frontotemporal dementia identifies focal mutations associated with widespread degeneration