A Space-Time Hidden Markov Model for In Vivo NanoScale Synaptic Plasticity Tracking

Kavli Affiliate: Adam S. Charles, Michael Miller, and Richard Huganir | Authors: Shashwat Kumar, Gabrielle I Coste, Dasun Premathilaka, Richard L. Huganir, Austin R Graves, Adam S Charles and Michael I Miller | Summary: Synapses are the fundamental unit of neural connectivity, exhibiting dynamic functional and structural changes that enable the brain to learn, adapt, […]


Continue.. A Space-Time Hidden Markov Model for In Vivo NanoScale Synaptic Plasticity Tracking

A Novel Therapeutic Approach: Gamma Secretase Inhibitor Enhances Radiotherapy and Checkpoint Blockade Therapy via Reprogramming of the Tumor Microenvironment

Kavli Affiliate: Michael Miller | Authors: Qi Wang, Debarshi Banerjee, Erin Connolly, Claire Vanpouille-Box, Carrie Shawber, Rami Vanguri, Michael Kissner, Michael L. Miller, Darrell J. Yamashiro and Eileen P. Connolly | Summary: Background High-dose radiotherapy (RT) in cancer is immunogenic but also induces an immunosuppressive tumor microenvironment (TME) that limits the efficacy of immune checkpoint […]


Continue.. A Novel Therapeutic Approach: Gamma Secretase Inhibitor Enhances Radiotherapy and Checkpoint Blockade Therapy via Reprogramming of the Tumor Microenvironment

Integrated Manufacturing Platform for Cortical Organoids Reveals Early Phosphatase and Prefoldin Dysregulation in MAPT V337M Neurons

Kavli Affiliate: Michael Miller | Authors: Taylor Bertucci, Kathryn R Bowles, Steven Lotz, Shiraz Bheda, Le Qi, Farhad Farjood, Katherine Whitton, Susan K Goderie, Susan Borden, Amelia Rossi, Kate Tubbesing, Chiara Pedicone, Laura Oja, Keith Lane, Ryan Lotz, Hailey Lotz, Jack Huber, Rebecca Chowdhury, Shona Joy, Michael Miller, David C Butler, Brigitte L Arduini, Heide […]


Continue.. Integrated Manufacturing Platform for Cortical Organoids Reveals Early Phosphatase and Prefoldin Dysregulation in MAPT V337M Neurons

Isolation and Characterization of Extracellular Vesicles from Mouse Retina Tissue

Kavli Affiliate: John Reynolds | Authors: Ishrat Ahmed, Olesia Gololobova, Mohammed Amanullah, Zach Troyer, Joshua H Yu, James T Handa, Jiang Qian, Seth Blackshaw and Kenneth Witwer | Summary: This protocol provides a standardized workflow for the isolation of extracellular vesicles (EVs) from mouse retinal tissue, and includes an assessment of EV size and concentration, […]


Continue.. Isolation and Characterization of Extracellular Vesicles from Mouse Retina Tissue

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction

Kavli Affiliate: Denis Wirtz | Authors: Kanako Iwasaki, Hui Pan, Jonathan M. Dreyfuss, Maya Jackson, Sergii Domanskyi, Dylan Baker, Priscila Carapeto, Christopher Cahill, Sandra Le, Francesko Hela, Juliana Alcoforado Diniz, Giray Naim Eryilmaz, Fan Wu, Pei-Hsun Wu, Bofei Yu, Denis Wirtz, Sara Espinoza, Alejandro Pena, Francisco G. Cigarroa, Gregory Abrahamian, Jillian L Woodworth, Peter D. […]


Continue.. Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction

Generation and validation of an Acan-Cre mouse line to selectively label Class-B excitatory neurons of the cerebellar nuclei

Kavli Affiliate: Justus M Kebschull | Authors: Julian Cheron, Maggie Lowman, Manjari Anant, Max Siauw and Justus M Kebschull | Summary: The cerebellar nuclei form the main output structures of the cerebellum and are composed of a deeply conserved set of cell types. Two excitatory cell classes, Class-A and -B, are present in each cerebellar […]


Continue.. Generation and validation of an Acan-Cre mouse line to selectively label Class-B excitatory neurons of the cerebellar nuclei

Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments

Kavli Affiliate: Patrick Kanold | Authors: Marina Cardoso de Oliveira and Patrick O Kanold | Summary: Listening in complex environments requires the enhancement of relevant sounds and suppression of irrelevant ones. Corticothalamic neurons (CTNs) in auditory cortex layer (L) 6 provide modulatory feedback to thalamic nuclei and to upper cortical layers and are thought to […]


Continue.. Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments

Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

Kavli Affiliate: Keri Martinowich | Authors: Sang Ho Kwon, Boyi Guo, Cindy Fang, Madhavi Tippani, Svitlana V Bach, Ryan A Miller, Sarah E Maguire, Artemis Iatrou, Geo Pertea, Nicholas J Eagles, Madeline R Valentine, Seyun Oh, Aarti Jajoo, Vijetha Balakundi, Yufeng Du, Annie B Nguyen, Ruth Zhang, Uma M Kaipa, Heena R Divecha, Jashandeep S. […]


Continue.. Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

Spatial Regulation of CAR Signaling Enables Logic-Gated Activity

Kavli Affiliate: Denis Wirtz | Authors: Tushar D Nichakawade, Brian Mog, Alexander D Pearlman, Taha S. Ahmedna, Nikita Marcou, Ricardo Mora-Cartin, Evangeline Watson, Bum Seok Lee, Sarah R. DiNapoli, Nickolas Papadopoulos, Chetan Bettegowda, Marco Dal Molin, Denis Wirtz, Drew M. Pardoll, Suman Paul, Surojit Sur, Kathleen L. Gabrielson, Shibin Zhou, Bert Vogelstein and Kenneth W. […]


Continue.. Spatial Regulation of CAR Signaling Enables Logic-Gated Activity

Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors

Kavli Affiliate: Richard Huganir | Authors: Sohum Mehta, Nidhi A. Thaker, Kengo Adachi, Christopher Y. Ko, Bian Liu, Sai S. Divkaruni, Oguz C. Koc, Anne C. Lyons, Samantha A. Sanchez, Pauline Löffler, Yoshihisa Nakahata, Jody L. Martin, Jared L. Johnson, Tomer M. Yaron-Barir, Lewis C. Cantley, Martin J. Lohse, Andreas Bock, Donald M. Bers, Ryohei […]


Continue.. Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors