Kavli Affiliate: Reza Shadmehr | Authors: Alden Shoup, Natasha Porwal, Mohammad Amin Fakharian, Paul Hage, Simon P Orozco and Reza Shadmehr | Summary: Electrophysiological recording with a new probe often yields better signal quality than with a used probe. Why does the signal quality degrade after only a few experiments? Here, we considered silicon probes […]
Kavli Affiliate: Xiaoqin Wang | Authors: Yang Zhang, Xindong Song, Yueqi Guo, Chenggang Chen, Michael S Osmanski and Xiaoqin Wang | Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive […]
Kavli Affiliate: Reza Shadmehr | Authors: Jay S Pi, Mohammad Amin Fakharian, Paul Hage, Ehsan Sedaghat-Nejad, Salomon Z Muller and Reza Shadmehr | Summary: Neurons in the inferior olive are thought to anatomically organize the Purkinje cells (P-cells) of the cerebellum into computational modules. To better understand what is computed by these modules, we designed […]
Kavli Affiliate: David Linden | Authors: Jessie Benedict, Robert H. Cudmore, David J. Linden, Diarra Oden and Aleah Spruell | Summary: Mammalian parenting is an unusually demanding commitment. How did evolution co-opt the reward system to ensure parental care? Previous work has implicated the lateral habenula (LHb), an epithalamic nucleus, as a potential intersection of […]
Kavli Affiliate: Denis Wirtz | Authors: Bartholomew Starich, Fan Yang, Derin Tanrioven, Heng-Chung Kung, Joanne Baek, Praful R. Nair, Pratik Kamat, Nico Macaluso, Joon Eoh, Kyu Sang Han, Luo Gu, Sean Sun, Pei-Hsun Wu, Denis Wirtz and Jude M. Phillip | Summary: Cellular senescence is a major driver of aging and disease. Here we show […]
Kavli Affiliate: Jean Fan | Authors: Gohta Aihara, Kalen Clifton, Mayling Chen, Lyla Atta, Brendan F. Miller and Jean Fan | Summary: Motivation Spatial omics data demand computational analysis but many analysis tools have computational resource requirements that increase with the number of cells analyzed. This presents scalability challenges as researchers use spatial omics technologies […]
Kavli Affiliate: Denis Wirtz | Authors: Irfan S Kathiriya, Martin H Dominguez, Kavitha S Rao, Jonathan M. Muncie-Vasic, W. Patrick Devine, Kevin M. Hu, Swetansu K Hota, Bayardo I Garay, Diego Quintero, Piyush Goyal, Megan N Matthews, Reuben Thomas, Tatyana Sukonnik, Dario Miguel-Perez, Sarah Winchester, Emily F Brower, André Forjaz, Pei-Hsun Wu, Denis Wirtz, Ashley […]
Kavli Affiliate: Vikram Chib | Authors: Aram Kim and Vikram S. Chib | Summary: Expectations as a reference point shape our decisions to motivate effortful activity. Despite the important role of reference points in human performance, little is known about how the brain processes expectations to guide motivated exertion. Participants completed a reward-based effort task […]
Kavli Affiliate: Brian Caffo Keri Martinowich | Authors: Jianing Yao, Jinglun Yu, Brian Caffo, Stephanie Cerceo Page, Keri Martinowich and Stephanie C Hicks | Summary: Recent advances in spatially-resolved single-omics and multi-omics technologies have led to the emergence of computational tools to detect or predict spatial domains. Additionally, histological images and immunofluorescence (IF) staining of […]
Kavli Affiliate: Brian Caffo Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Abstract Batch effects, undesirable sources of variability across multiple experiments, present significant challenges for scientific and clinical discoveries. Batch effects […]