Memory erasure by dopamine-gated retrospective learning

Kavli Affiliate: Patricia Janak | Authors: Huijeong Jeong, Leo Zsembik, Farah Farouq, Risha Chakraborty, Nishita Belur, Mingkang Zhou, Andrea D. Sanders, Styra X. Wang, Ananya Srinivasan, Sylvia M. L. Cox, Eric Garr, Sara Brooke, Patricia H. Janak, Marco Leyton, Ritchie Chen and Vijay Mohan K. Namboodiri | Summary: Erasing outdated memories is crucial for adaptive […]


Continue.. Memory erasure by dopamine-gated retrospective learning

Quantifying information stored in synaptic connections rather than in firing activities of neural networks

Kavli Affiliate: Shreesh P. Mysore | Authors: Xinhao Fan and Shreesh P Mysore | Summary: A cornerstone of our understanding of both biological and artificial neural networks is that they store information in the strengths of synaptic connections among the neurons. However, in contrast to the well-established theory for quantifying information encoded by the firing […]


Continue.. Quantifying information stored in synaptic connections rather than in firing activities of neural networks

Inhibition of CKAMP44 attenuated seizure activity via protein phosphatase 3 regulatory subunit B-mediated GluA1 phosphorylation and synaptic transmission

Kavli Affiliate: Xiaoqin Wang | Authors: Lihong Huang, Shiyu Chen, Haokun Guo, Hui Zhang, Liang Wang, Xiaoqin Wang, Yiming Guo, Shiyun Yuan, Jing Luo, Yang Lv and Weihua Yu | Summary: Abstract Temporal lobe epilepsy (TLE) is a complex neurological disorder characterized by spontaneous recurrent seizures and its underlying mechanism remains elusive. This study aimed […]


Continue.. Inhibition of CKAMP44 attenuated seizure activity via protein phosphatase 3 regulatory subunit B-mediated GluA1 phosphorylation and synaptic transmission

A recurrent neural network model of chronic pain development and recovery

Kavli Affiliate: Michael Miller | Authors: Katherine Huang, Guy Marmor, Tjitse van der Molen, Zongren Zhang, Paulina Gicqueau, Javier Reveles, Kareena Morrissey, Justin Tang, Lucy Lu, Kelly Ilmi, Jacob Lue, Gabriela Barba Zuniga, Michael B. Miller, Kenneth S. Kosik, Henry Yang, Tyler Santander, Francesco Bullo and Paul K. Hansma | Summary: Chronic pain presents a […]


Continue.. A recurrent neural network model of chronic pain development and recovery

Representations converge as brain maps diverge along the cortical hierarchy

Kavli Affiliate: Martin Lindquist | Authors: Bogdan Petre, Martin A Lindquist and Tor Wager | Summary: Brain maps (e.g. topographies like retinotopy, somatotopy) vary across individuals. This is thought to reflect computational differences, motivating personalized functional localization. However, artificial neural networks (ANNs) show that similar performance and internal representations can coexist with diverse circuit layouts. […]


Continue.. Representations converge as brain maps diverge along the cortical hierarchy

Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Kavli Affiliate: Jean Fan | Authors: Srujan Singh, Shishir Kumar Patel, Ryo Matsuura, Dee Velazquez, Zhaoli Sun, Sanjeev Noel, Hamid Rabb and Jean Fan | Summary: Kidney transplantation is the gold standard treatment strategy for end-stage renal disease. Deceased donor kidneys usually undergo cold storage until kidney transplantation, leading to cold ischemia injury that may […]


Continue.. Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changes

Virtual multiplex staining of the pancreatic islets across type 1 diabetes progression using a Schroedinger bridge

Kavli Affiliate: Martin Lindquist | Authors: Yu Shen, Won June Cho, Saurabh Joshi, Benjamin Wen, Swarnagouri Naganathanhalli, Maria Beery, Casey R Grubel, Arrun Sivasubramanian, André Forjaz, Mia P Grahn, Lucie Dequiedt, Yichen Huang, Kyu Sang Han, Fan Wu, Brian A Pedro, Laura D Wood, Tiane Chen, Ralph H Hruban, Irina Kusmartseva, Mark A Atkinson, Denis […]


Continue.. Virtual multiplex staining of the pancreatic islets across type 1 diabetes progression using a Schroedinger bridge

The Common Fund Data Ecosystem (CFDE)

Kavli Affiliate: Martin Lindquist | Authors: Julie A. Jurgens, Andreas Bueckle, Jeet Vora, Mano R. Maurya, Taha Mohseni Ahooyi, Erika Zheng, Benjamin Stear, Ding Wang, Caitlin Ree, Srinivasan Ramachandran, Anton Nekrutenko, MacKenzie Brandes, Swathi Thaker, Daniel H. Katz, Monica C. Munoz-Torres, Ido Diamant, Hye-Jung E. Chun, J. Alan Simmons, Sarah K. Tasian, Sherry L. Jenkins, […]


Continue.. The Common Fund Data Ecosystem (CFDE)

Acyl-enzyme dynamics, tautomerisation and hydration regulate turnover of carbapenem antibiotics by the OXA-48 β-lactamase

Kavli Affiliate: Michael Beer | Authors: Joseph F Hoff, Michael Beer, Philip Hinchliffe, Catherine L Tooke, Christopher J Schofield, Marc W van der Kamp, Adrian J Mulholland and James Spencer | Summary: OXA-48 is a globally disseminated class D serine β-lactamase that efficiently confers resistance to a range of β-lactam antibiotics, including carbapenems, the most […]


Continue.. Acyl-enzyme dynamics, tautomerisation and hydration regulate turnover of carbapenem antibiotics by the OXA-48 β-lactamase

Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Marco Costa, Catarina Oliveira, Paul A. Gensbigler, Lucie Dequiedt, Vasco Queiroga, Saurabh Joshi, William Foster, Matthieu Wyart, Marjorie R. Grafe, Owen J McCarty, Gabriel S. Bever, Jamie O Lo, Brice Menard, Sean X. Sun, Ashley L Kiemen and Denis Wirtz | Summary: The vascular and nervous systems […]


Continue.. Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development