BARseq3: a modular system for integrating spatial multi-omics and cellular barcoding in single cells

Kavli Affiliate: Justus M Kebschull | Authors: Huihui Qi, Manjari M-G Anant, Dylan Z Faltine-Gonzalez, Ruitao Hu, Lai Wei, Christopher D Workman, Caleb Shi, Ishbel Del Rosario and Justus M Kebschull | Summary: Understanding cellular identity requires multimodal measurements in single cells. Cellular barcoding provides powerful tools for recording the properties or history of individual […]


Continue.. BARseq3: a modular system for integrating spatial multi-omics and cellular barcoding in single cells

Granger Sensori-Behavioral Taxonomy of Neuronal Ensemble Activity from Two-Photon Calcium Imaging Data

Kavli Affiliate: Patrick Kanold | Authors: Sahar Khosravi, Nikolas A. Francis, Patrick O. Kanold and Behtash Babadi | Summary: Understanding how neuronal populations interact to encode and transform sensory information is a fundamental challenge in computational neuroscience. Most existing studies, however, study neural encoding, behavioral readout, and functional connectivity as disjoint problems. Two-photon calcium imaging […]


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The Central Nucleus of the Amygdala Encodes the Motivation to Pursue Ethanol

Kavli Affiliate: Patricia Janak | Authors: Matilde Castro, Jingren Gu, Teresa Dong, David J. Ottenheimer, Céline Drieu and Patricia H. Janak | Summary: Prior studies implicate the central nucleus of the amygdala (CeA) in reward motivation, yet how this region encodes motivation for ethanol (EtOH) seeking and consumption–and how this compares to encoding of natural […]


Continue.. The Central Nucleus of the Amygdala Encodes the Motivation to Pursue Ethanol

MM-ComBat and MM-CovBat: Multivariate Frameworks for Joint Harmonization of Multi-Metric Neuroimaging Data

Kavli Affiliate: Martin Lindquist | Authors: Zheng Ren, Patrick Sadil and Martin Lindquist | Summary: Aggregating neuroimaging data across sites and studies is increasingly common, yet site- and scanner-related batch effects can obscure meaningful biological variation and introduce spurious associations. Although ComBat and its extensions are widely used, they are primarily designed for single-metric harmonization. […]


Continue.. MM-ComBat and MM-CovBat: Multivariate Frameworks for Joint Harmonization of Multi-Metric Neuroimaging Data

Hippocampal theta frequency as a readout of path-integration recalibration

Kavli Affiliate: James Knierim | Authors: Seong-Beom Park, Manu Madhav, Ravikrishnan P Jayakumar, Noah Cowan and James J Knierim | Summary: Understanding how the brain represents hidden variables is a fundamental challenge. In navigation, the internal path-integration gain is often masked by external landmarks that override the path integrator. Path integration can recalibrate its gain […]


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Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart

Kavli Affiliate: Jean Fan | Authors: Yuening Liu, Annabelle M. Coles, Jonah Castiglione, Vijay Venu Thiyagarajan, Kalen Clifton, Deevanshu Goyal, Jerry Wu, Arlo Sheridan, Ana Vujic, Kristen M. Harris, Uri Manor, Talmo D. Pereira, Jean Fan, Richard T. Lee and Pallav Kosuri | Summary: Resilience to cardiac stress is essential for health, yet the relationship […]


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Real-time AI integration for MR to detect artifacts and guide pulse sequence adaptations

Kavli Affiliate: Jeremias Sulam/p> | Authors: Aaron T. Gudmundson, Zahra Shams, Abdelrahman Gad, Shuyuan Wang, Dunja Simicic, Saipavitra Murali-Manohar, Gizeaddis Lamesgin Simegn, Ipek Özdemir, Christopher W. Davies-Jenkins, Vivek Yedavalli, Georg Oeltzschner, Omer Burak Demirel, Jeremias Sulam, Michael schär, Sandeep Ganji and Richard A. E. Edden | Summary: Purpose To present a first-of-its-kind artificial intelligence (AI-)integrated […]


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Accumulation of neural state transitions in dorsomedial striatum predicts patch foraging decisions

Kavli Affiliate: Marshall Hussain Shuler | Authors: Elissa Sutlief, Shichen Zhang, Kate Forsberg and Marshall G Hussain Shuler | Summary: Activities with temporally distributed returns require deciding not only what to do, but when to stop. Although optimal foraging theory predicts that patch departure should depend on the total time invested in a patch, behavior […]


Continue.. Accumulation of neural state transitions in dorsomedial striatum predicts patch foraging decisions

Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex

Kavli Affiliate: Michael Miller | Authors: Diane D Shao, Yifan Zhao, Joseph Brew, Yahia Adla, Urmi Ghosh, Vinayak V Viswanadham, Lovelace J Luquette, Sijing Zhao, Andrea J Kriz, Xuyu Qian, Takumi Taketomi, Shannon Coy, Sandro Santagata, Michael B Miller, Fuminori Tsuruta, Peter J Park and Christopher A Walsh | Summary: Human neurons are postmitotic and […]


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Aging Impairs Temporal Integration in Supragranular but Not Thalamorecipient Layers of Primary Auditory Cortex

Kavli Affiliate: Patrick Kanold | Authors: Yunru Chen and Patrick O Kanold | Summary: Speech has harmonic features and speech perception is impaired in aging. Imaging of auditory cortex (A1) in aged mice shows reduced selectivity to harmonic sounds and impaired temporal integration of component frequencies especially in layers 2/3 but not layer 4, suggesting […]


Continue.. Aging Impairs Temporal Integration in Supragranular but Not Thalamorecipient Layers of Primary Auditory Cortex