Transcriptional Control of Neocortical Size and Microcephaly

Kavli Affiliate: Kristina Nielsen Loyal Goff | Authors: Soraia Barao, Yijun Xu, Rachel Vistein, Loyal Goff, Kristina Nielsen, Byoung-Il Bae, Richard S. Smith, Christopher A Walsh, Genevieve Stein O Brien and Ulrich Muller | Summary: The neocortex varies in size and complexity among mammals due to the tremendous variability in the number and diversity of […]


Continue.. Transcriptional Control of Neocortical Size and Microcephaly

Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain

Kavli Affiliate: Martin Lindquist | Authors: Brent William Stewart, Michael L Keaser, Hwiyoung Lee, Sarah M Margerison, Matthew A Cormie, Massieh Moayedi, Martin Lindquist, Shuo Chen, Brian N. Mathur and David A Seminowicz | Summary: Aberrant cognitive network activity and cognitive deficits are established features of chronic pain. However, the nature of cognitive network alterations […]


Continue.. Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain

Structure-Based Discovery of a NPFF1R Antagonist with Analgesic Activity

Kavli Affiliate: Jin Kang | Authors: Brian J Bender, Julie E Pickett, Joao Braz, Hye Jin Kang, Stefan Gahbauer, Karnika Bhardwaj, Sian Rodriguez-Rosado, Yongfeng Liu, Manish Jain, Allan Basbaum, Bryan L Roth and Brian K. Shoichet | Summary: While opioid drugs remain among the most effective analgesics for pain management, adverse effects limit their use. […]


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Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming

Kavli Affiliate: Alex Kolodkin | Authors: Noelle Thielman, Vanessa Funes, Sanjana Davuluri, Hector lbanez, Wei-Chih Sun, Juan Fu, Keyu Li, Stephen Muth, Xingyi Pan, Kenji Fujiwara, Dwayne Thomas, MacKenzie Henderson, Selina Shiqing Teh, Qingfeng Zhu, Elizabeth Thompson, Elizabeth M Jaffee, Alex Kolodkin, Fengxi Meng and Lei Zheng | Summary: Axon guidance molecules were found to […]


Continue.. Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming

Honey varietals differentially impact Bifidobacterium animalis ssp lactis survivability in yogurt through simulated in vitro digestion

Kavli Affiliate: Michael Miller | Authors: David A. Alvarado, Luis Alberto Ibarra-Sanchez, Annemarie R. Mysonhimer, Tauseef A Khan, Rong Cao, Michael J. Miller and Hannah Holscher | Summary: Background Bifidobacterium animalis ssp. lactis DN-173 010/CNCM I-2494 (B. animalis) is a probiotic strain commonly added to yogurt. Yogurt and honey are a popular culinary pairing. Honey […]


Continue.. Honey varietals differentially impact Bifidobacterium animalis ssp lactis survivability in yogurt through simulated in vitro digestion

Ancient midbrain inhibitory neurons control selective spatial attention

Kavli Affiliate: Shreesh P. Mysore | Authors: Ninad B Kothari, Wen-Kai You, Arunima Banerjee, Qingcheng Zhang and Shreesh P Mysore | Summary: Animal behavior at any instant is guided by information from only a subset of the plethora of stimuli in their sensory environments. The neural circuit mechanisms that select a behaviorally relevant ‘target’ from […]


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Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science

Kavli Affiliate: Laurent Younes & Donald Geman | Authors: Kun Yang, Koko Ishizuka, Andrew P Lane, Zui Narita, Arisa Hayashida, Yukiko Y Lema, Emma Heffron, Haydn Loudd, Maeve Schumacher, Shin-ichi Kano, Toshifumi Tomoda, Atsushi Kamiya, Minghong Ma, Donald Geman, Laurent Younes and Akira Sawa | Summary: Biopsy is crucial in clinical medicine to obtain tissues […]


Continue.. Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science

Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Kavli Affiliate: Jean Fan | Authors: Rafael dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Lyla Atta, Manjari Anant, Mark A Atkinson, Todd M Brusko, Clive H Wasserfall and Jean Fan | Summary: Spatially resolved omics technologies provide molecular profiling of cells while preserving their organization within tissues, allowing for the evaluation of cell-type […]


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Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Kavli Affiliate: Michael Beer | Authors: Jin Woo Oh and Michael A Beer | Summary: Gene regulatory elements drive many complex biological phenomena such as fetal development, and their mutations are linked to a multitude of common human diseases. The phenotypic impacts of regulatory variants are often tested using their conserved orthologous counterparts in model […]


Continue.. Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Whole-cortex in situ sequencing reveals peripheral input-dependent cell type-defined area identity

Kavli Affiliate: Patrick Kanold | Authors: Xiaoyin Chen, Stephan Fischer, Mara CP Rue, Aixin Zhang, Didhiti Mukherjee, Patrick O Kanold, Jesse Gillis and Anthony Zador | Summary: The cortex is composed of neuronal types with diverse gene expression that are organized into specialized cortical areas. These areas, each with characteristic cytoarchitecture (Brodmann 1909; Vogt and […]


Continue.. Whole-cortex in situ sequencing reveals peripheral input-dependent cell type-defined area identity