Kavli Affiliate: Alex Pollen | Authors: Jingwen W Ding, Chang N Kim, Marilyn R Steyert, Andrew T Yuan, David Shin, Dimitar Ivanov, Tomasz J. Nowakowski and Alex Aaron Pollen | Summary: Down syndrome (DS), caused by trisomy 21 (TS21), is the most common genetic cause of intellectual disability1,2. The neurological impacts of DS first manifest […]
Kavli Affiliate: Denis Wirtz | Authors: Praful R Nair, Eban Hanna, Saurabh Joshi, Victoria Duarte Alvarado, Challice Bonifant and Denis Wirtz | Summary: Cellular immunotherapy has shown remarkable efficacy in hematological malignancies but remains limited by infiltration issues in solid tumors, leading to poor treatment efficacy. We have recently shown that mesothelin-targeting CAR T cells […]
Kavli Affiliate: Leslie B. Vosshall | Authors: Olivia V. Goldman, Alexandra E. DeFoe, Yanyan Qi, Yaoyu Jiao, Shih-Che Weng, Leah Houri-Zeevi, Priyanka Lakhiani, Takeshi Morita, Jacopo Razzauti, Adriana Rosas-Villegas, Yael N. Tsitohay, Madison M. Walker, Ben R. Hopkins, Mosquito Cell Atlas Consortium, Omar S. Akbari, Laura B. Duvall, Helen White-Cooper, Trevor R. Sorrells, Roshan Sharma, […]
Kavli Affiliate: Vincent Ferrera and Jacqueline Gottlieb | Authors: Yuhao Jin, Greg Jensen, Vincent Ferrera and Jacqueline Gottlieb | Summary: In natural environments, associations that indicate true learnable regularities are intermixed with those that arise from random and ultimately unlearnable relationships between events. To efficiently allocate cognitive resources and avoid inferring spurious patterns, organisms must […]
Kavli Affiliate: Seth Blackshaw | Authors: Haley Appel, Rogger Carmen-Orozco, Clayton Santiago, Thanh Hoang and Seth Blackshaw | Summary: The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes […]
Kavli Affiliate: Seth Blackshaw | Authors: Jingliang Simon Zhang, Brian Guy, Clayton P Santiago, Caterina Tiozzo, Meghana Sreenath, Ya-Wen Chen, Seth Blackshaw and Robert J Johnston, Jr | Summary: Retinal ganglion cells (RGCs) are the projection neurons that transmit visual information from the retina to the brain. In many species, a substantial proportion of RGCs […]
Kavli Affiliate: Anastasia Kiyonaga | Authors: Sihan Yang, Yueying Dong and Anastasia Kiyonaga | Summary: Working memory (WM) representations that are distributed across the brain can be flexibly recruited to best guide behavior1–4. For instance, information may be represented relatively more strongly in visual cortex when a WM task requires fine visual detail, or more […]
Kavli Affiliate: Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Madison M. Walker, Jacopo Razzauti, Anurag Sharma, H. Amalia Pasolli and Leslie B. Vosshall | Summary: Mosquitoes, the world’s deadliest animal, exemplify single-mating systems where females mate only once in their lifetime, making mate choice critically important for reproductive success and mosquito control. Despite this importance, […]
Kavli Affiliate: Robert Edwards | Authors: Jacob Kelman, Meena Khan, Chibundu Umunna, Russell Brainard, Grace Donohue, Robert A Edwards, Natalie A Falta, Emma E. George, Eleanor Gorham, Juris Grasis, Kevin Green, Andreas F Haas, Kimberly Halsey, Eric Hester, Summer Jacob, Aydin Loid Karatas, Yan Wei Lim, Mark Little, Stuart Sandin, Jessie Segnitz, Maya Serota, Natalia […]
Kavli Affiliate: Arnold R. Kriegstein | Authors: Elizabeth Alexandra Cooper, David A Posner, Colin Y. C Lee, Linda Hu, Sigourney Bonner, Jessica T Taylor, Oscar Baldwin, Rocio Jimenez-Guerrero, Katherine E Masih, Katherine Wickham Rahrmann, Jason Eigenbrood, Gina Ngo, Valar Nila Roamio Franklin, Clive D’Santos, Richard Mair, Thomas Santarius, Claudia Craven, Ibrahim Jalloh, Julia Moreno-Vicente, Timotheus […]