Protein Structure Informed Bacteriophage Genome Annotation with Phold

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: George Bouras, Susanna R Grigson, Milot Mirdita, Michael Heinzinger, Bhavya Papudeshi, Vijini Mallawaarachchi, Renee Green, Rachel Seongeun Kim, Victor Mihalia, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde, Martin Steinegger and Robert A Edwards | Summary: Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for […]


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Modeling hidden cognitive states reveals acute and chronic effects of fentanyl on decision-making

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | Authors: Zhenlong Zhang, Patricia H. Janak and Eric Garr | Summary: The cognitive mechanisms underlying behavior are often dynamic, shifting gradually or abruptly over time scales spanning years, to weeks, to minutes. Whether drug-induced changes in learning and decision-making follow similarly dynamic patterns remains unclear. To address this, we apply […]


Continue.. Modeling hidden cognitive states reveals acute and chronic effects of fentanyl on decision-making

Sequence termination cues drive habits via dopamine-mediated credit assignment

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Yifeng Cheng, Joanna Zhou, Haley Province, Nathalie Thiriet, Patricia H Janak and Youna Vandaele | Summary: Background Mesolimbic dopamine (DA) neurons are central to cue guided reward seeking and action sequence learning. Yet, the mechanisms by which cue-induced DA neural activity drives goal-directed or habitual sequence execution […]


Continue.. Sequence termination cues drive habits via dopamine-mediated credit assignment

Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

Posted by dbos Hopkins

Kavli Affiliate: Solomon Snyder | Authors: Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwran Chakraborty, Sunil Jamuna Tripathi, Ryan S Dhindsa, Samaneh Saberi, Julia E Lefler, Priyanka Kothari, Cristina Ricco, Kalyani Chaubey, Adele M Snowman, Michael C Ostrowski, Eugenio Barone, Lakshiminarayan M Iyer, L Aravind, Sudarshana M Sharma, Andrew A Pieper, Bobby Thomas, Solomon H […]


Continue.. Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

Cell Cycle Arrest of a “Zippering” Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders

Posted by dbos UCSF

Kavli Affiliate: Georgia Panagiotakos | Authors: Tiange Qu, Brandon H Chacon, Louis Faure, Marta Losa, Rocio Hernandez-Martinez, Kelsey Robinson, Aragorn Jones, Steven Lisgo, Maurizio Risolino, Jaiden De Anda, Georgia Panagiotakos, Elizabeth J Leslie-Clarkson, Igor Adameyko and Licia Selleri | Summary: Facial features identify individuals, but the mechanisms shaping the human face remain elusive. Orofacial clefting […]


Continue.. Cell Cycle Arrest of a “Zippering” Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders

MAPseq2: a sensitive and cost-effective barcoded connectomics method

Posted by dbos Hopkins

Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Huihui Qi, Craig Washington, Xiaoping Liang and Justus M Kebschull | Summary: The barcoded connectomics tool MAPseq enables highly multiplexed projection mapping of individual neurons by translating neuroanatomy into a DNA sequencing problem. Here we present MAPseq2, a user-friendly protocol with 3-4 fold increased barcode detection […]


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Heterochromatin-based silencing of a foreign tandem repeat in Drosophila melanogaster shows unusual biochemistry and temperature sensitivity

Posted by dbos Yale

Kavli Affiliate: Elena Gracheva | Authors: Tingting Gu, Elena Gracheva, Michael Lee, Wilson M Leung, Sophia Bieser, Alixandria Nielsen, Adam T. Smiley, Nhi N.T. Vuong, Matthias Walther, Gunter Reuter, Sarah C.R. Elgin and Andrew M Arsham | Summary: Eukaryotic genomes are packaged into chromatin, a regulatory nucleoprotein assembly. Establishment, maintenance, and interconversion of chromatin states […]


Continue.. Heterochromatin-based silencing of a foreign tandem repeat in Drosophila melanogaster shows unusual biochemistry and temperature sensitivity

Fast photostimulus optimization for holographic control of neural ensemble activity in vivo

Posted by dbos Columbia

Kavli Affiliate: Liam Paninski and Darcy Peterka | Authors: Marcus A Triplett, Edgar Bäumler, Alex Prodan, Rokas Stonis, Darcy S Peterka, Michael Häusser and Liam Paninski | Summary: Determining the intricate structure and function of neural circuits requires the ability to precisely manipulate circuit activity. Two-photon holographic optogenetics has emerged as a powerful tool for […]


Continue.. Fast photostimulus optimization for holographic control of neural ensemble activity in vivo

Human Strategy Adaptation in Reinforcement Learning Resembles Policy Gradient Ascent

Posted by dbos UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Hua-Dong Xiong, Li Ji-An, Robert C Wilson and Marcelo G Mattar | Summary: A hallmark of intelligence is the ability to adapt behavior to changing environments, which requires adapting one’s own learning strategies. This phenomenon is known as learning to learn in cognitive science and meta-learning in artificial intelligence. […]


Continue.. Human Strategy Adaptation in Reinforcement Learning Resembles Policy Gradient Ascent

A sensitive orange fluorescent calcium ion indicator for imaging neural activity

Posted by dbos UCSD / Salk

Kavli Affiliate: Timothy Brown | Authors: Abhi Aggarwal, Heather A. Baker, Celine D. Durst, I-Wen Chen, Pablo de Chambrier, Julia Marie Gonzales, Jonathan S. Marvin, Milene Vandal, Torgny Lundberg, Kenryo Sakoi, Ronak H Patel, Ching-Yao Wang, Frank Visser, Yannick Fouad, Smrithi Sunil, Matthew Wiens, Takuya Terai, Kei Takahashi-Yamashiro, Roger J. Thompson, Timothy A. Brown, Yusuke […]


Continue.. A sensitive orange fluorescent calcium ion indicator for imaging neural activity