Hyper-migratory CAR T cells alleviate ovarian cancer metastatic burden and improve prognosis

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Praful R Nair, Eban Hanna, Saurabh Joshi, Victoria Duarte Alvarado, Challice Bonifant and Denis Wirtz | Summary: Cellular immunotherapy has shown remarkable efficacy in hematological malignancies but remains limited by infiltration issues in solid tumors, leading to poor treatment efficacy. We have recently shown that mesothelin-targeting CAR T cells […]


Continue.. Hyper-migratory CAR T cells alleviate ovarian cancer metastatic burden and improve prognosis

Effects of Primordial Black Holes on IGM History

Posted by klaurent Chicago

Kavli Affiliate: Nickolay Y. Gnedin | First 5 Authors: Emily Koivu, Emily Koivu, , , | Summary: Currently the asteroid mass window (mass $sim 10^17- 10^21$ grams) remains unconstrained for Primordial Black Holes (PBHs) to make up all of the dark matter content of the universe. Given these PBHs have very small masses, their Hawking […]


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JADES: The Star Formation and Dust Attenuation Properties of Galaxies at 3<z<7

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | First 5 Authors: Charity Woodrum, Charity Woodrum, , , | Summary: We present the star formation and dust attenuation properties for a sample of 602 galaxies at redshifts $rm3<z<7$, as part of the JADES survey. Our analysis is based on measurements of the $rmHalpha/rmHbeta$ Balmer Decrement using medium resolution (R$sim$1000) […]


Continue.. JADES: The Star Formation and Dust Attenuation Properties of Galaxies at 3<z<7

A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

Posted by dbos Rockefeller

Kavli Affiliate: Leslie B. Vosshall | Authors: Olivia V. Goldman, Alexandra E. DeFoe, Yanyan Qi, Yaoyu Jiao, Shih-Che Weng, Leah Houri-Zeevi, Priyanka Lakhiani, Takeshi Morita, Jacopo Razzauti, Adriana Rosas-Villegas, Yael N. Tsitohay, Madison M. Walker, Ben R. Hopkins, Mosquito Cell Atlas Consortium, Omar S. Akbari, Laura B. Duvall, Helen White-Cooper, Trevor R. Sorrells, Roshan Sharma, […]


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Single-Neuron Encoding of Learnability in the Dorsal Anterior Cingulate Cortex

Posted by dbos Columbia

Kavli Affiliate: Vincent Ferrera and Jacqueline Gottlieb | Authors: Yuhao Jin, Greg Jensen, Vincent Ferrera and Jacqueline Gottlieb | Summary: In natural environments, associations that indicate true learnable regularities are intermixed with those that arise from random and ultimately unlearnable relationships between events. To efficiently allocate cognitive resources and avoid inferring spurious patterns, organisms must […]


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JWST-discovered AGN: evidence for heavy obscuration in the type-2 sample from the first stacked X-ray detection

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | First 5 Authors: Andrea Comastri, Andrea Comastri, , , | Summary: One of the most puzzling properties of the high-redshift AGN population recently discovered by JWST, including both broad-line and narrow-line sources, is their X-ray weakness. With very few exceptions, and regardless of the optical classification, they are undetected at […]


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The warm outer layer of a Little Red Dot as the source of [Fe II] and collisional Balmer lines with scattering wings

Posted by klaurent MIT

Kavli Affiliate: Robert A. Simcoe | First 5 Authors: Alberto Torralba, Alberto Torralba, , , | Summary: The population of the Little Red Dots (LRDs) may represent a key phase of supermassive black hole (SMBH) growth. A cocoon of dense excited gas is emerging as key component to explain the most striking properties of LRDs, […]


Continue.. The warm outer layer of a Little Red Dot as the source of [Fe II] and collisional Balmer lines with scattering wings

A Multiwavelength View of $ρ$ Oph I: Resolving the X-ray Source Between A and B

Posted by klaurent MIT

Kavli Affiliate: David P. Huenemoerder | First 5 Authors: Sean J. Gunderson, Sean J. Gunderson, , , | Summary: We present a multiwavelength analysis of the central stellar pair of $rho$ Oph, components A and B. Using recent high-resolution textitChandra X-ray Observatory observations, we demonstrate with high confidence that the dominant X-ray source is $rho$ […]


Continue.. A Multiwavelength View of $ρ$ Oph I: Resolving the X-ray Source Between A and B