Automated 3D analysis of social head-gaze behaviors in freely moving marmosets

Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Alec Graham Sheffield, Monika P. Jadi, Steve W. C. Chang and Anirvan S. Nandy | Summary: Social communication relies on the ability to perceive and interpret the direction of others’ attention, which is commonly conveyed through head orientation and gaze direction in both humans and non-human primates. […]


Continue.. Automated 3D analysis of social head-gaze behaviors in freely moving marmosets

Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Kavli Affiliate: Mary E. Hatten | Authors: Michalina Hanzel, Kayla Fernando, Susan E Maloney, Shioaching Gong, Kärt Mätlik, Jiajia Zhao, H Amalia Pasolli, Søren Heissel, Joseph D Dougherty, Court Hull and Mary E Hatten | Summary: Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and […]


Continue.. Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Evidence for Episodic Black Hole Growth of Reionization-Era Quasars observed with Magellan/FIRE

Kavli Affiliate: Robert A. Simcoe | First 5 Authors: Leah Bigwood, Anna-Christina Eilers, Robert A. Simcoe, , | Summary: Observations of high-redshift quasars hosting billion solar mass black holes at $zgtrsim6$ challenge our understanding of early supermassive black hole (SMBH) growth. In this work, we conduct a near-infrared spectroscopic study of $19$ quasars at $6.2lesssim […]


Continue.. Evidence for Episodic Black Hole Growth of Reionization-Era Quasars observed with Magellan/FIRE

Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions

Kavli Affiliate: Marina Picciotto | Authors: Paul Jongseo Lee, Alexa R Soares, Yu Sun, Caroline Fai, Marina Picciotto and Junjie U Guo | Summary: While previous studies suggest that many mRNAs contain more than one translation initiation site (TIS), the biological significance of most alternative TISs and their corresponding protein isoforms (proteoforms) remains undetermined. Here […]


Continue.. Alternative translation initiation produces synaptic organizer proteoforms with distinct localization and functions

Degron-based bioPROTACs for controlling signaling in CAR T cells

Kavli Affiliate: Hana El-Samad | Authors: Matthew S Kim, Hersh K Bhargava, Gavin E Shavey, Wendell A Lim, Hana El-Samad and Andrew H Ng | Summary: Chimeric antigen receptor (CAR) T cells have made a tremendous impact in the clinic, but potent signaling through the CAR can be detrimental to treatment safety and efficacy. The […]


Continue.. Degron-based bioPROTACs for controlling signaling in CAR T cells

Hierarchical Prior-based Super Resolution for Point Cloud Geometry Compression

Kavli Affiliate: Jing Wang | First 5 Authors: Dingquan Li, Kede Ma, Jing Wang, Ge Li, | Summary: The Geometry-based Point Cloud Compression (G-PCC) has been developed by the Moving Picture Experts Group to compress point clouds. In its lossy mode, the reconstructed point cloud by G-PCC often suffers from noticeable distortions due to the […]


Continue.. Hierarchical Prior-based Super Resolution for Point Cloud Geometry Compression

Low-Dose CT Reconstruction Using Dataset-free Learning

Kavli Affiliate: Feng Wang | First 5 Authors: Feng Wang, Renfang Wang, Hong Qiu, , | Summary: Low-Dose computer tomography (LDCT) is an ideal alternative to reduce radiation risk in clinical applications. Although supervised-deep-learning-based reconstruction methods have demonstrated superior performance compared to conventional model-driven reconstruction algorithms, they require collecting massive pairs of low-dose and norm-dose […]


Continue.. Low-Dose CT Reconstruction Using Dataset-free Learning

Low-Dose CT Reconstruction Using Dataset-free Learning

Kavli Affiliate: Feng Wang | First 5 Authors: Feng Wang, Renfang Wang, Hong Qiu, , | Summary: Low-Dose computer tomography (LDCT) is an ideal alternative to reduce radiation risk in clinical applications. Although supervised-deep-learning-based reconstruction methods have demonstrated superior performance compared to conventional model-driven reconstruction algorithms, they require collecting massive pairs of low-dose and norm-dose […]


Continue.. Low-Dose CT Reconstruction Using Dataset-free Learning

Low-Dose CT Reconstruction Using Dataset-free Learning

Kavli Affiliate: Feng Wang | First 5 Authors: Feng Wang, Renfang Wang, Bo Yang, Hong Qiu, | Summary: Low-Dose computer tomography (LDCT) is an ideal alternative to reduce radiation risk in clinical applications. Although supervised-deep-learning-based reconstruction methods have demonstrated superior performance compared to conventional model-driven reconstruction algorithms, they require collecting massive pairs of low-dose and […]


Continue.. Low-Dose CT Reconstruction Using Dataset-free Learning

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Ryan J Farrell, Kirsten G Bredvik, Michael Blake Hoppa, S Thomas Hennegan, Timothy A Brown and Timothy A Ryan | Summary: The endoplasmic reticulum (ER) is an important regulator of Ca2+ in cells and dysregulation of ER calcium homeostasis can lead to numerous pathologies. Understanding how […]


Continue.. A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions