Layer 5a Corticostriatal Projection Neurons are Selectively Vulnerable in Huntington’s Disease

Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in the Huntington’s disease (HD) cortex, the nature of somatic CAG expansion […]


Continue.. Layer 5a Corticostriatal Projection Neurons are Selectively Vulnerable in Huntington’s Disease

Cell Type Specific CAG Repeat Expansion and Toxicity of Mutant Huntingtin in Human Striatal and Cerebellar Cell Types

Kavli Affiliate: Nathaniel Heintz | Authors: Kert Mätlik, Matthew Baffuto, Laura Kus, David A Davis, Matthew R Paul, Thomas S Carroll and Nathaniel Heintz | Summary: Tissue-specific somatic expansion of the mutant Huntingtin (mHTT) CAG tract and regional degeneration of the brain are key features of Huntington’s disease (HD). However, the relationships between somatic CAG […]


Continue.. Cell Type Specific CAG Repeat Expansion and Toxicity of Mutant Huntingtin in Human Striatal and Cerebellar Cell Types

Insights for disease modeling from single cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

Kavli Affiliate: Loyal Goff | Authors: Debamitra Das, Shreyash Sonthalia, Genevieve G Stein-O’Brien, Marah Wahbeh, Kyra Feuer, Loyal Goff, Carlo Colantuoni, Vasiliki Machairaki and Dimitrios Avramopoulos | Summary: Trans-differentiation of human induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons for disease modeling and in vitro […]


Continue.. Insights for disease modeling from single cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-culture

A spatially resolved single cell genomic atlas of the adult human breast

Kavli Affiliate: Robert Edwards | Authors: Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Hu, Anna Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, Ken Chen, Benedikt Nilges, Nachiket Kashikar, Oliver Braubach, Bassem Cheikh, Nadya Nikulina, Hui Chen, Mediate Teshome, Brian Menegaz, Huma […]


Continue.. A spatially resolved single cell genomic atlas of the adult human breast

Once Detected, Never Lost: Surpassing Human Performance in Offline LiDAR based 3D Object Detection

Kavli Affiliate: Feng Wang | First 5 Authors: Lue Fan, Yuxue Yang, Yiming Mao, Feng Wang, Yuntao Chen | Summary: This paper aims for high-performance offline LiDAR-based 3D object detection. We first observe that experienced human annotators annotate objects from a track-centric perspective. They first label the objects with clear shapes in a track, and […]


Continue.. Once Detected, Never Lost: Surpassing Human Performance in Offline LiDAR based 3D Object Detection

Non-linear optics at twist interfaces in h-BN/SiC heterostructures

Kavli Affiliate: Xiang Zhang | First 5 Authors: Abhijit Biswas, Rui Xu, Gustavo A. Alvarez, Jin Zhang, Joyce Christiansen-Salameh | Summary: Understanding the emergent electronic structure in twisted atomically thin layers has led to the exciting field of twistronics. However, practical applications of such systems are challenging since the specific angular correlations between the layers […]


Continue.. Non-linear optics at twist interfaces in h-BN/SiC heterostructures

Non-linear optics at twist interfaces in h-BN/SiC heterostructures

Kavli Affiliate: Zhiting Tian | First 5 Authors: Abhijit Biswas, Rui Xu, Gustavo A. Alvarez, Jin Zhang, Joyce Christiansen-Salameh | Summary: Understanding the emergent electronic structure in twisted atomically thin layers has led to the exciting field of twistronics. However, practical applications of such systems are challenging since the specific angular correlations between the layers […]


Continue.. Non-linear optics at twist interfaces in h-BN/SiC heterostructures

Imaging 3D Chemistry at 1 nm Resolution with Fused Multi-Modal Electron Tomography

Kavli Affiliate: Ting Xu | First 5 Authors: Jonathan Schwartz, Zichao Wendy Di, Yi Jiang, Jason Manassa, Jacob Pietryga | Summary: Measuring the three-dimensional (3D) distribution of chemistry in nanoscale matter is a longstanding challenge for metrological science. The inelastic scattering events required for 3D chemical imaging are too rare, requiring high beam exposure that […]


Continue.. Imaging 3D Chemistry at 1 nm Resolution with Fused Multi-Modal Electron Tomography

X-ray nanotomography reveals formation of single diamonds by block copolymer self-assembly

Kavli Affiliate: Ulrich B. Wiesner | First 5 Authors: Kenza Djeghdi, Dmitry Karpov, S. Narjes Abdollahi, Karolina Godlewska, Mirko Holler | Summary: Block copolymers are recognised as a valuable platform for creating nanostructured materials with unique properties. Morphologies formed by block copolymer self-assembly can be transferred into a wide range of inorganic materials, enabling applications […]


Continue.. X-ray nanotomography reveals formation of single diamonds by block copolymer self-assembly

The origin of long soft lags and the nature of the hard-intermediate state in black hole binaries

Kavli Affiliate: Tadayuki Takahashi | First 5 Authors: Tenyo Kawamura, Chris Done, Tadayuki Takahashi, , | Summary: Fast variability of the X-ray corona in black hole binaries can produce a soft lag by reverberation, where the reprocessed thermalized disc photons lag behind the illuminating hard X-rays. This lag is small, and systematically decreases with increasing […]


Continue.. The origin of long soft lags and the nature of the hard-intermediate state in black hole binaries