Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Kavli Affiliate: Anders Dale | Authors: Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Anders Dale, Eivind Hovig and Ole Andreassen | Summary: Abstract Discoveries from genome-wide association studies often contain large clusters of highly correlated genetic variants, which makes them hard to interpret. In such cases, finemapping the underlying causal variants […]


Continue.. Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Performant web-based interactive visualization tool for spatially-resolved transcriptomics experiments

Kavli Affiliate: Keri Martinowich | Authors: Chaichontat Sriworarat, Annie B. Nguyen, Nicholas J. Eagles, Leonardo Collado-Torres, Keri Martinowich, Kristen R. Maynard and Stephanie C. Hicks | Summary: High-resolution and multiplexed imaging techniques are giving us an increasingly detailed observation of a biological system. However, sharing, exploring, and customizing the visualization of large multidimensional images can […]


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Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Kavli Affiliate: Denis Wirtz | Authors: Alicia M Braxton, Ashley L Kiemen, Mia P Grahn, Andre Forjaz, Jaanvi Mahesh Babu, Lily Zheng, Liping Jiang, Haixia Cheng, Qianqian Song, Rebecca Reichel, Sarah Graham, Alexander I Damanakis, Catherine G Fischer, Stephanie Mou, Cameron Metz, Julie Granger, Xiao-Ding Liu, Niklas Bachmann, Cristina Almagro-Perez, Ann Chenyu Jiang, Jeonghyun Yoo, […]


Continue.. Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Nanomechanical absorption spectroscopy of 2D materials with femtowatt sensitivity

Kavli Affiliate: Herre Van Der Zant | First 5 Authors: Jan N. Kirchhof, Yuefeng Yu, Denis Yagodkin, Nele Stetzuhn, Daniel B. de Araújo | Summary: Nanomechanical spectroscopy (NMS) is a recently developed approach to determine optical absorption spectra of nanoscale materials via mechanical measurements. It is based on measuring changes in the resonance frequency of […]


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Hubble Constant Measurement from Three Large-Separation Quasars Strongly Lensed by Galaxy Clusters

Kavli Affiliate: Michael D. Gladders | First 5 Authors: Kate Napier, Keren Sharon, Håkon Dahle, Matthew Bayliss, Michael D. Gladders | Summary: Tension between cosmic microwave background-based and distance ladder-based determinations of the Hubble constant ${rm H}_{rm 0}$ motivates pursuit of independent methods that are not subject to the same systematic effects. A promising alternative, […]


Continue.. Hubble Constant Measurement from Three Large-Separation Quasars Strongly Lensed by Galaxy Clusters

Surface acoustic wave resonators on thin film piezoelectric substrates in the quantum regime

Kavli Affiliate: Simon Groblacher | First 5 Authors: Thomas Luschmann, Alexander Jung, Stephan Geprägs, Franz X. Haslbeck, Achim Marx | Summary: Lithium niobate (LNO) is a well established material for surface acoustic wave (SAW) devices including resonators, delay lines and filters. Recently, multi-layer substrates based on LNO thin films have become commercially available. Here, we […]


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Soliton pulse pairs at multiple colors in normal dispersion microresonators

Kavli Affiliate: Kerry Vahala | First 5 Authors: Zhiquan Yuan, Maodong Gao, Yan Yu, Heming Wang, Warren Jin | Summary: Soliton microcombs are helping to advance the miniaturization of a range of comb systems. These combs mode lock through the formation of short temporal pulses in anomalous dispersion resonators. Here, a new microcomb is demonstrated […]


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Engineered zero-dispersion microcombs using CMOS-ready photonics

Kavli Affiliate: Kerry Vahala | First 5 Authors: Qing-Xin Ji, Warren Jin, Lue Wu, Yan Yu, Zhiquan Yuan | Summary: Normal group velocity dispersion (GVD) microcombs offer high comb line power and high pumping efficiency compared to bright pulse microcombs. The recent demonstration of normal GVD microcombs using CMOS-foundry-produced microresonators is an important step towards […]


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Contribution of protein conformational heterogeneity to NMR lineshapes at cryogenic temperatures

Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Keith Fritzsching, Rivkah Rogawski, Yunyao Xu and Ann E McDermott | Summary: While low temperature NMR holds great promise for the analysis of unstable samples and for sensitizing NMR detection, spectral broadening in frozen protein samples is a common experimental challenge. One hypothesis explaining the additional linewidth […]


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Predicted and Experimental NMR Chemical Shifts at Variable Temperatures: The Effect of Protein Conformational Dynamics

Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Lichirui Zhang, Richard Friesner and Ann E McDermott | Summary: NMR chemical shifts provide a sensitive probe of protein structure and dynamics. Prediction of shifts, and therefore interpretation of shifts, particularly for the frequently measured amidic 15N sites, remains a tall challenge. We demonstrate that protein 15N […]


Continue.. Predicted and Experimental NMR Chemical Shifts at Variable Temperatures: The Effect of Protein Conformational Dynamics