The younger flagellum coordinates the beating in C. reinhardtii

Posted by klaurent Delft

Kavli Affiliate: Marie-Eve Aubin-Tam | Summary:Eukaryotes swim with coordinated flagellar (ciliary) beating and steer by fine-tuning the coordination. The model organism for studying flagellate motility, C. reinhardtii (CR), employs synchronous, breast-stroke-like flagellar beating to swim, and it modulates the beating amplitudes differentially to steer. This strategy hinges on both inherent flagellar asymmetries (e.g. different response […]


Continue.. The younger flagellum coordinates the beating in C. reinhardtii

Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Anders Dale, Eivind Hovig and Ole Andreassen | Summary: Abstract Discoveries from genome-wide association studies often contain large clusters of highly correlated genetic variants, which makes them hard to interpret. In such cases, finemapping the underlying causal variants […]


Continue.. Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Performant web-based interactive visualization tool for spatially-resolved transcriptomics experiments

Posted by klaurent Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Chaichontat Sriworarat, Annie B. Nguyen, Nicholas J. Eagles, Leonardo Collado-Torres, Keri Martinowich, Kristen R. Maynard and Stephanie C. Hicks | Summary: High-resolution and multiplexed imaging techniques are giving us an increasingly detailed observation of a biological system. However, sharing, exploring, and customizing the visualization of large multidimensional images can […]


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Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Alicia M Braxton, Ashley L Kiemen, Mia P Grahn, Andre Forjaz, Jaanvi Mahesh Babu, Lily Zheng, Liping Jiang, Haixia Cheng, Qianqian Song, Rebecca Reichel, Sarah Graham, Alexander I Damanakis, Catherine G Fischer, Stephanie Mou, Cameron Metz, Julie Granger, Xiao-Ding Liu, Niklas Bachmann, Cristina Almagro-Perez, Ann Chenyu Jiang, Jeonghyun Yoo, […]


Continue.. Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Hubble Constant Measurement from Three Large-Separation Quasars Strongly Lensed by Galaxy Clusters

Posted by Chicago

Kavli Affiliate: Michael D. Gladders | First 5 Authors: Kate Napier, Keren Sharon, Håkon Dahle, Matthew Bayliss, Michael D. Gladders | Summary: Tension between cosmic microwave background-based and distance ladder-based determinations of the Hubble constant ${rm H}_{rm 0}$ motivates pursuit of independent methods that are not subject to the same systematic effects. A promising alternative, […]


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Surface acoustic wave resonators on thin film piezoelectric substrates in the quantum regime

Posted by klaurent Delft

Kavli Affiliate: Simon Groblacher | First 5 Authors: Thomas Luschmann, Alexander Jung, Stephan Geprägs, Franz X. Haslbeck, Achim Marx | Summary: Lithium niobate (LNO) is a well established material for surface acoustic wave (SAW) devices including resonators, delay lines and filters. Recently, multi-layer substrates based on LNO thin films have become commercially available. Here, we […]


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Contribution of protein conformational heterogeneity to NMR lineshapes at cryogenic temperatures

Posted by klaurent Columbia

Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Keith Fritzsching, Rivkah Rogawski, Yunyao Xu and Ann E McDermott | Summary: While low temperature NMR holds great promise for the analysis of unstable samples and for sensitizing NMR detection, spectral broadening in frozen protein samples is a common experimental challenge. One hypothesis explaining the additional linewidth […]


Continue.. Contribution of protein conformational heterogeneity to NMR lineshapes at cryogenic temperatures

Predicted and Experimental NMR Chemical Shifts at Variable Temperatures: The Effect of Protein Conformational Dynamics

Posted by klaurent Columbia

Kavli Affiliate: Ann McDermott | Authors: Xu Yi, Lichirui Zhang, Richard Friesner and Ann E McDermott | Summary: NMR chemical shifts provide a sensitive probe of protein structure and dynamics. Prediction of shifts, and therefore interpretation of shifts, particularly for the frequently measured amidic 15N sites, remains a tall challenge. We demonstrate that protein 15N […]


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Zinc Alters the Supramolecular Organization of Nucleic Acid Complexes with Full-Length TIA1

Posted by klaurent Columbia

Kavli Affiliate: Ann McDermott | Authors: Yizhuo Yang, Keith Fritzsching, Sasha He and Ann E McDermott | Summary: T-Cell Intracellular Antigen-1 (TIA1) is a 43 kDa multi-domain RNA-binding protein involved in stress granule formation during eukaryotic stress response, and has been implicated in neurodegenerative diseases including Welander distal myopathy and amyotrophic lateral sclerosis. TIA1 contains […]


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Mapping the X-ray variability of GRS1915+105 with machine learning

Posted by dbos MIT

Kavli Affiliate: Ronald A. Remillard | First 5 Authors: Benjamin J. Ricketts, James F. Steiner, Cecilia Garraffo, Ronald A. Remillard, Daniela Huppenkothen | Summary: Black hole X-ray binary systems (BHBs) contain a close companion star accreting onto a stellar-mass black hole. A typical BHB undergoes transient outbursts during which it exhibits a sequence of long-lived […]


Continue.. Mapping the X-ray variability of GRS1915+105 with machine learning