Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

Posted by klaurent Hopkins

Kavli Affiliate: Michael Beer | Authors: Catherine L Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlie K Colenso, Christopher J Schofield, Adrian J Mulholland and James Spencer | Summary: Abstract KPC-2 (Klebsiella pneumoniae carbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism […]


Continue.. Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase

Inflammation-Responsive Micellar Nanoparticles from Degradable Polyphosphoramidates for Targeted Delivery to Myocardial Infarction

Posted by klaurent UCSD / Salk

Kavli Affiliate: Karen Christman | Authors: Yifei Liang, Holly Sullivan, Kendal Carrow, Joanna Korpanty, Kendra Worthington, Colin Luo, Karen L Christman and Nathan C Gianneschi | Summary: ABSTRACT Nanoparticles that undergo a localized morphology change to target areas of inflammation have been previously developed but are limited by their lack of biodegradability. In this paper, […]


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Circuit dissection and functional validation of a cross-species emotional biomarker

Posted by klaurent UCSF

Kavli Affiliate: Edward Chang, Vikaas Sohal | Authors: Adam Jackson, Josh Cohen, Aarron Phensy, Edward F Chang, Heather Dawes and Vikaas Sohal | Summary: ABSTRACT Emotional responses arise from limbic circuits including the hippocampus and amygdala. In the human brain, beta-frequency communication between these structures correlates with self-reported mood and anxiety. However, both the mechanism […]


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$d$-wave Superconductivity, Pseudogap, and the Phase Diagram of $t$-$t’$-$J$ Model at Finite Temperature

Posted by dbos UCAS

Kavli Affiliate: Gang Su | First 5 Authors: Dai-Wei Qu, Bin-Bin Chen, Xin Lu, Qiaoyi Li, Shou-Shu Gong | Summary: Recently, a robust $d$-wave superconductivity has been unveiled in the ground state of the 2D $t$-$t’$-$J$ model — with both nearest-neighbor ($t$) and next-nearest-neighbor ($t’$) hoppings — through the density matrix renormalization group calculations in […]


Continue.. $d$-wave Superconductivity, Pseudogap, and the Phase Diagram of $t$-$t’$-$J$ Model at Finite Temperature

A Multi-Qubit Quantum Gate Using the Zeno Effect

Posted by klaurent Berkeley

Kavli Affiliate: Birgitta Whaley | First 5 Authors: Philippe Lewalle, Leigh S. Martin, Emmanuel Flurin, Song Zhang, Eliya Blumenthal | Summary: The Zeno effect, in which repeated observation freezes the dynamics of a quantum system, stands as an iconic oddity of quantum mechanics. When a measurement is unable to distinguish between states in a subspace, […]


Continue.. A Multi-Qubit Quantum Gate Using the Zeno Effect

A Multi-Qubit Quantum Gate Using the Zeno Effect

Posted by klaurent Berkeley

Kavli Affiliate: Birgitta Whaley | First 5 Authors: Philippe Lewalle, Leigh S. Martin, Emmanuel Flurin, Song Zhang, Eliya Blumenthal | Summary: The Zeno effect, in which repeated observation freezes the dynamics of a quantum system, stands as an iconic oddity of quantum mechanics. When a measurement is unable to distinguish between states in a subspace, […]


Continue.. A Multi-Qubit Quantum Gate Using the Zeno Effect