MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Kavli Affiliate: Dwight Bergles | Authors: Em P Harrington, Riley B Catenacci, Matthew D Smith, Dongeun Heo, Cecilia E Miller, Keya R Meyers, Jenna Glatzer, Dwight E Bergles and Peter A Calabresi | Summary: Abstract Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown […]


Continue.. MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Towards a nonperturbative construction of the $S$-matrix

Kavli Affiliate: Hitoshi Murayama | First 5 Authors: Brian Henning, Hitoshi Murayama, Francesco Riva, Jedidiah O. Thompson, Matthew T. Walters | Summary: We present a nonperturbative recipe for directly computing the $S$-matrix in strongly-coupled QFTs. The method makes use of spectral data obtained in a Hamiltonian framework and can be applied to a wide range […]


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Report of the Instrumentation Frontier Working Group for Snowmass 2021

Kavli Affiliate: Kent Irwin | First 5 Authors: Phil Barbeau, Petra Merkel, Jinlong Zhang, Darin Acosta, Anthony A. Affolder | Summary: Detector instrumentation is at the heart of scientific discoveries. Cutting edge technologies enable US particle physics to play a leading role worldwide. This report summarizes the current status of instrumentation for High Energy Physics […]


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On ${mathcal N}=4$ supersymmetry enhancements in three dimensions

Kavli Affiliate: Yuji Tachikawa | First 5 Authors: Benjamin Assel, Yuji Tachikawa, Alessandro Tomasiello, , | Summary: We introduce a class of 3d theories consisting of strongly-coupled ${mathcal N}=4$ systems coupled to ${mathcal N}=3$ Chern-Simons gauge multiplets, which exhibit ${mathcal N}=4$ enhancements when a peculiar condition on the Chern-Simons levels is met. An example is […]


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Zero-Shot 3D Drug Design by Sketching and Generating

Kavli Affiliate: Yi Zhou | First 5 Authors: Siyu Long, Yi Zhou, Xinyu Dai, Hao Zhou, | Summary: Drug design is a crucial step in the drug discovery cycle. Recently, various deep learning-based methods design drugs by generating novel molecules from scratch, avoiding traversing large-scale drug libraries. However, they depend on scarce experimental data or […]


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Feasibility Analyses and Experimental Confirmation of Dove Prism Based Dual-fiberscope Rotary Joint

Kavli Affiliate: Xingde Li | Authors: Yuehan Liu, Hyeon-Cheol Park, Haolin Zhang and Xingde Li | Summary: Abstract Two-photon fluorescence microscopy has enjoyed its wide adoption in neuroscience. Head-mounted miniaturized fiberscopes offered an exciting opportunity for enabling neural imaging in freely-behaving animals with high 3D resolution. Here we propose a dual-fiberscope rotary joint based on […]


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Validation of TOI-1221 b, a warm sub-Neptune exhibiting TTVs around a Sun-like star

Kavli Affiliate: Roland Vanderspek | First 5 Authors: Christopher R. Mann, David Lafrenière, Diana Dragomir, Samuel N. Quinn, Thiam-Guan Tan | Summary: We present a successful validation of the long-period ($91.68278^{+0.00032}_{-0.00041}$ days) transiting sub-Neptune planet TOI-1221 b (TIC 349095149.01) around a Sun-like (m$_{rm V}$=10.5) star. We combine {it TESS} light curve measurements and ground-based time-series […]


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Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Kavli Affiliate: Samuel Pfaff | Authors: Lydia Daboussi, Giancarlo Costaguta, Miriam Gullo, Veronica Pessino, Brendan O’Leary, Karen Lettieri, Shawn Driscoll and Samuel L. Pfaff | Summary: Abstract Schwann cells respond to acute axon damage by transiently transdifferentiating into specialized repair cells that restore sensorimotor function. However, the molecular systems controlling repair cell formation and function […]


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Report of the Topical Group on Physics Beyond the Standard Model at Energy Frontier for Snowmass 2021

Kavli Affiliate: Marcela Carena | First 5 Authors: Tulika Bose, Antonio Boveia, Caterina Doglioni, Simone Pagan Griso, James Hirschauer | Summary: This is the Snowmass2021 Energy Frontier (EF) Beyond the Standard Model (BSM) report. It combines the EF topical group reports of EF08 (Model-specific explorations), EF09 (More general explorations), and EF10 (Dark Matter at Colliders). […]


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Role of the Hubble Scale in the Weak Lensing vs. CMB Tension

Kavli Affiliate: Wayne Hu | First 5 Authors: Lucas F. Secco, Tanvi Karwal, Wayne Hu, Elisabeth Krause, | Summary: We explore a re-parameterization of the lensing amplitude tension between weak lensing (WL) and cosmic microwave background (CMB) data and its implications for a joint resolution with the Hubble tension. Specifically, we focus on the lensing […]


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