Kavli Affiliate: Vikaas Sohal | Authors: Aarron Justin Phensy, Lara Louise Hagopian, Caitriona M. Costello, Simon Haziza, Omkar Ghenand, Yanping Zhang, Mark J. Schnitzer and Vikaas Singh Sohal | Summary: Cognitive dysfunction in conditions such as schizophrenia involves disrupted communication between the prefrontal cortex (PFC) and mediodorsal thalamus (MD). Parvalbumin interneurons (PVI) are known to […]

Kavli Affiliate: Seth Shipman | Authors: Linhan Wang, Nikolaos Poulis, Deepak Srivastava and Seth Shipman | Summary: Genetically encoded DNA recorders convert transient biological events into stable genomic mutations, offering a means to reconstruct past cellular states. However, current approaches to log historical events by modifying genomic DNA have limited capacity to record the magnitude […]

Kavli Affiliate: Lily Jan and Yuh Nung Jan | Authors: Xiaofan Zhang, Wei Chen, Yayu Wang, Xun Tu, Xiangyu Zhang, Ronald L. Davis, Lily Yeh Jan and Yuh Nung Jan | Summary: ABSTRACT Neuronal remodeling is essential for sculpting neural circuits, and its disruption has been implicated in neurodevelopmental and neuropsychiatric disorders. Yet the molecular […]

Kavli Affiliate: Alex Pollen | Authors: Sara Nolbrant, Jenelle L. Wallace, Jingwen Ding, Tianjia Zhu, Jess L. Sevetson, Janko Kajtez, Isabella A. Baldacci, Emily K. Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T. Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J. Pavlovic, Sofie R. Salama, Agnete Kirkeby, Hao Huang, Nathan K. Schaefer and Alex A. […]

Kavli Affiliate: Philip Starr | Authors: Abhinav Sharma, Bahman Abdi Sargezeh, Amelia Hahn, Maria Shcherbakova, Wolf Julian Neumann, Simon Little, Philip Starr and Ashwini Oswal | Summary: Background: Bradykinesia in Parkinson′s disease (PD) may arise due to transient, network–wide neural dynamics that extend beyond beta–band oscillatory activity within the motor cortical-subthalamic nucleus (STN) circuit. Methods: […]

Kavli Affiliate: Daniele Canzio and Stavros Lomvardas | Authors: Martin Escamilla-del-Arenal, Rachel Duffie, Hani Shayya, Valentina Loconte, Axel Ekman, Lena Annika Street, Adan Horta, Daniele Canzio, Kevin Monahan, Carolyn A Larabell, Marko Jovanovic and Stavros Lomvardas/p> | Summary: Diverse epigenetic regulatory mechanisms ensure and regulate cellular diversity. Among others, the histone 3 lysine 9 me3 […]

Kavli Affiliate: Edward Chang | Authors: Jeremy Saal, Kelly Kadlec, Anusha B. Allawala, Lucille Johnston, Ryan Leriche, Ritwik Vatsyayan, Yiyuan Han, Audrey Kist, Tommaso Di Ianni, Heather E. Dawes, Edward F. Chang, A Moses Lee, Andrew D. Krystal, Khaled Moussawi, Prasad Shirvalkar and Kristin K. Sellers | Summary: Background: Deep-brain stimulation (DBS) is increasingly being […]

Kavli Affiliate: Kevin Bender | Authors: Hao Wu, Luqun Shen, Jonathan Indajang, Neil K Savalia, Timothy G Johnson, Jiayin Qu, Kevin J Bender and Alex C Kwan | Summary: SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical pyramidal cells. However, the impact of Scn2a […]

Kavli Affiliate: Vikaas Sohal | Authors: Carlos Johnson-Cruz, Kathleen K.A. Cho and Vikaas S. Sohal | Summary: The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it critical to understand how the dynamic updating vs. stable maintenance of different encodings contribute to behavioral adaptation. We addressed this […]

Kavli Affiliate: Vikaas Sohal | Authors: Carlos Johnson-Cruz, Kathleen K.A. Cho and Vikaas S. Sohal | Summary: The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it critical to understand how the dynamic updating vs. stable maintenance of different encodings contribute to behavioral adaptation. We addressed this […]