ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Alex Pollen | Authors: Matthew T. Schmitz, Jingwen W. Ding, Sara Nolbrant, Reed McMullen, Chang N. Kim, Bryan J. Pavlovic, Tomasz J. Nowakowski, Trygve E. Bakken, Chun Jimmie Ye and Alex Aaron Pollen | Summary: Diverse neurons and glia are […]


Continue.. ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain

Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

Kavli Affiliate: Xin Duan | Authors: Kriti Chaplot, Lin Zhang, Julia Wessman, Miguel Rivera, Zhihui Wang, Fei Wang, Xin Duan, Pamela M. England, Iain C. Clark and Erik M. Ullian | Summary: In vitro modelling of highly vulnerable nigral dopaminergic (DA) neuronal subtypes in Parkinson’s disease (PD), is necessary for studying disease mechanisms. Here, we […]


Continue.. Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

Reverse transcribed ssDNA derepresses translation of a retron antiviral protein

Kavli Affiliate: Seth Shipman | Authors: Karen Zhang, Matías Rojas-Montero, Darshini Poola, Josepha Klas, Arturo Carabias, Dennis Zhang, Mario R Mestre, Ruiliang Zhao, Ana Dávila-Hidalgo, Guillermo Montoya, Rafael Pinilla-Redondo, Alejandro González-Delgado and Seth L Shipman | Summary: Retrons are bacterial immune systems that prevent the spread of phages by initiating a toxic response within infected […]


Continue.. Reverse transcribed ssDNA derepresses translation of a retron antiviral protein

REM sleep predicts reductions in pathophysiological daytime basal ganglia-cortical circuit activity in Parkinson’s disease

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Philip Starr | Authors: Jin-Xiao Zhang, Clay Smyth, Hanna Cattan-Hayat, Md Fahim Anjum, Yue Leng, Andrew D. Krystal, Philip A. Starr and Simon Little | Summary: Sleep disturbances have been shown to be intimately and bidirectionally related to disease progression […]


Continue.. REM sleep predicts reductions in pathophysiological daytime basal ganglia-cortical circuit activity in Parkinson’s disease

Antibody Reveals Conformational Latch Controlling Herpesvirus Proteases

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Yifan Cheng | Authors: Marcell Zimanyi, Kaitlin R Hulce, Markus F Bohn, Jordan Norman, Peter J Rohweder, Yifan Cheng and Charles Craik | Summary: Human herpesviruses (HHVs) are widespread pathogens that cause severe disease. Their replication depends on the HHV […]


Continue.. Antibody Reveals Conformational Latch Controlling Herpesvirus Proteases

Sensorimotor Theta Oscillations Coordinate Speech Movements

Kavli Affiliate: Edward Chang and Loren Frank | Authors: Yitzhak Norman, Loren M. Frank and Edward F. Chang | Summary: Fluent speech depends on precisely timed motor commands that coordinate rapid transitions between successive articulatory gestures. Using direct cortical recordings, we identified a prominent sensorimotor theta oscillation (6–10 Hz) that supports this coordination. During articulation, […]


Continue.. Sensorimotor Theta Oscillations Coordinate Speech Movements

Ingestion-activated CGRP neurons control learning but not satiety

Kavli Affiliate: Zachary Knight | Authors: Brooke C Jarvie, Anagh Ravi, Rhea Nanavati, Longhui Qui, Truong Ly, Jun Y Oh, Olivia K Barnhill and Zachary A Knight | Summary: Calcitonin Gene-Related Peptide (CGRP) neurons in the parabrachial nucleus are critical for sickness and malaise but have also been proposed to control non-aversive (rewarding) satiation. How […]


Continue.. Ingestion-activated CGRP neurons control learning but not satiety

Cell-Intrinsic Vulnerability and Immune Activation Cooperate to Drive Degeneration in a Mitochondrial Complex I Deficiency Model of Optic Neuropathy

Kavli Affiliate: Xin Duan | Authors: Daniela Santamaria-Munoz, Raenier V. Reyes, Miranda R. Krueger, Andrea Garcia-Llorca, Brennan Marsh-Armstrong, Xin Duan, Yang Hu, Derek S. Welsbie, Nicholas Marsh-Armstrong, Elisenda Sanz, Albert Quintana, Sergi Simo and Anna La Torre | Summary: Mitochondrial dysfunction is a central hallmark of many optic neuropathies, yet the mechanisms linking intrinsic metabolic […]


Continue.. Cell-Intrinsic Vulnerability and Immune Activation Cooperate to Drive Degeneration in a Mitochondrial Complex I Deficiency Model of Optic Neuropathy

A Dual Inhibitory Network in the Thalamic Reticular Nucleus Delineated by Pallidal and Intra-Reticular Inhibition

Kavli Affiliate: Jeanne Paz | Authors: Frances S. Cho, John R. Huguenard and Jeanne T. Paz | Summary: Long described as an inhibitory “guardian of the gateway,” the thalamic reticular nucleus (TRN) shapes which thalamic signals reach the cortex during attention, arousal, and sensory processing. However, how the inhibitory wiring within TRN supports this flexible […]


Continue.. A Dual Inhibitory Network in the Thalamic Reticular Nucleus Delineated by Pallidal and Intra-Reticular Inhibition

Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics

Kavli Affiliate: Kristofer Bouchard | Authors: Pierre-Marie Garderes, Daniel E. Feldman and Kristofer E. Bouchard | Summary: Electrocorticography (ECoG) provides a high-spatiotemporal-resolution measure of cortical activity (cortical surface electrical potentials, CSEPs) in humans and animals. The CSEP high-gamma band (Hγ, 65–170 Hz) correlates with neuronal firing rates at the columnar spatial scale and is widely […]


Continue.. Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics