Kavli Affiliate: Xin Duan | Authors: Junyi Chen, Danqing Yin, Harris Y. H. Wong, Xin Duan, Ken H. O. Yu and Joshua W. K. Ho | Summary: The rapidly growing collection of public single-cell sequencing data have become a valuable resource for molecular, cellular and microbial discovery. Previous studies mostly overlooked detecting pathogens in human […]
Kavli Affiliate: Arturo Alvarez-Buylla, Andrea Hasenstaub, Michael Stryker | Authors: Walter R Mancia Leon, David M Steffen, Fiona Dale-Huang, Benjamin Rakela, Arnar Breevoort, Ricardo Romero-Rodriguez, Andrea R Hasenstaub, Michael P Stryker, Joshua A Weiner and Arturo Alvarez-Buylla | Summary: Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory interneurons (cINs) are born in the ventral […]
Kavli Affiliate: Saul Kato | Authors: Morgan M Stanton, Sara Modan, Patrick M Taylor, Harsh N Hariani, Jordan Sorokin, Brian G Rash, Sneha B Rao, Alejandro Lopez-Tobon, Luigi Enriquez, Brenda Dang, Dorah Owango, Shannon O’Neill, Carlos Castrillo, Justin Nicola, Kathy Ye, Robert M Blattner, Federico Gonzalez, Dexter Antonio, Pavan Ramkumar, Andy Lash, Douglas Flanzer, Sophia […]
Kavli Affiliate: Michael Keiser | Authors: Daniel R. Wong, Shino D. Magaki, Harry V. Vinters, William H. Yong, Edwin S. Monuki, Christopher K. Williams, Alessandra C. Martini, Charles DeCarli, Chris Khacherian, John P. Graff, Brittany N. Dugger and Michael J. Keiser | Summary: Precise, scalable, and quantitative evaluation of whole slide images is crucial in […]
Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]
Kavli Affiliate: Noelle Letoile, Saul Kato | Authors: Kelli L. Benedetti, Fatema A Saifuddin, Julia M Miller, Kevin Daigle, Rashmi Chandra, Alec Chen, Christine Lin, Angel Jacob Garcia, Burhanuddin Calcuttawala, Angelica Tovar, Raymond L Dunn, Jackson Borchardt, Julia A Kaye, Bo Zhang, Saul Kato, Maria E Gallegos, Torsten Wittmann and Noelle L’Etoile | Summary: SUMMARY […]
Kavli Affiliate: Michael Brainard | Authors: Bradley M Colquitt, Kelly Li, Foad Green, Robert J Veline and Michael S Brainard | Summary: SUMMARY Sensory feedback is required for stable execution of learned motor skills, and its loss can severely disrupt motor performance. The neural mechanisms that mediate sensorimotor stability have been extensively studied at systems […]
Kavli Affiliate: Daniel Minor | Authors: Daniel L Minor, Jr., Zhou Chen and Abhisek Mondal | Summary: Abstract Gabapentinoid drugs for pain and anxiety act on the CaVα2δ-1 and CaVα2δ-2 subunits of high-voltage activated calcium channels (CaV1s and CaV2s). Here, we present the cryo-EM structure of the gabapentin-bound brain and cardiac CaV1.2/CaVβ3/CaVα2δ-1 channel. The data […]
Kavli Affiliate: Kristofer Bouchard | Authors: Jiali Lu, Sumithra Surendralal, Kristofer E Bouchard and Dezhe Z. Jin | Summary: Abstract Songs of the Bengalese finch consist of variable sequences of syllables. The sequences follow probabilistic rules, and can be statistically described by partially observable Markov models (POMMs), which consist of states and probabilistic transitions between […]
Kavli Affiliate: Edward Chang, Vikaas Sohal | Authors: Adam Jackson, Josh Cohen, Aarron Phensy, Edward F Chang, Heather Dawes and Vikaas Sohal | Summary: ABSTRACT Emotional responses arise from limbic circuits including the hippocampus and amygdala. In the human brain, beta-frequency communication between these structures correlates with self-reported mood and anxiety. However, both the mechanism […]