Kavli Affiliate: Yifan Cheng | Authors: Maxine Bi, Xudong Wang, Jinan Wang, JUN xu, Wenkai Sun, Victtor Ayo Adediwrua, Yinglong Miao, Yifan Cheng and Libin Ye | Summary: Despite hundreds of GPCR-Gαβγ complex structures, these snapshots uniquely capture the fully activated complex. Consequently, a comprehensive understanding of the conformational transitions during GPCR activation and the […]
Kavli Affiliate: Loren Frank | Authors: Kyu Hyun Lee, Eric L. Denovellis, Ryan Ly, Jeremy Magland, Jeff Soules, Alison E Comrie, Daniel P Gramling, Jennifer A Guidera, Rhino Nevers, Philip Adenekan, Chris Brozdowski, Samuel R Bray, Emily Monroe, Ji Hyun Bak, Michael Coulter, Xulu Sun, Emrey Broyles, Donghoon Shin, Sharon Chiang, Cristofer Holobetz, Andrew Tritt, […]
Kavli Affiliate: Zachary Knight and Jeffrey M. Friedman | Authors: Christin Kosse, Jessica Ivanov, Zachary Knight, Kyle Pellegrino and Jeffrey Friedman | Summary: TThe brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the underlying circuitry linking inputs to outputs is unknown. Here we delineate a subcortical circuit in […]
Kavli Affiliate: Robert Edwards | Authors: George Bouras, Ghais Houtak, Ryan R Wick, Vijini Mallawaarachchi, Michael J. Roach, Bhavya Papudeshi, Louise M Judd, Anna E Sheppard, Robert A Edwards and Sarah Vreugde | Summary: Improvements in the accuracy and availability of long-read sequencing mean that complete bacterial genomes are now routinely reconstructed using hybrid (i.e. […]
Kavli Affiliate: Xin Duan | Authors: Dong Liu, Hannah C. Webber, Fuyun Bian, Yangfan Xu, Manjari Prakash, Xue Feng, Ming Yang, Hang Yang, In-Jee You, Liang Li, Liping Liu, Pingting Liu, Haoliang Huang, Chien-Yi Chang, Liang Liu, Sahil H. Shah, Anna La Torre, Derek S. Welsbie, Yang Sun, Xin Duan, Jeffrey L Goldberg, Marcus Braun, […]
Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Robert A Edwards, Michael J. Roach, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Joel Brame, Anna Heintz-Buschart, Timothy R Cavagnaro, Elizabeth A Dinsdale, Michael P Doane, Nico Eisenhauer, Grace Mitchell, Bibishan Rai, Sunita Ramesh and Martin F Breed | Summary: Microbiomes are critical to the […]
Kavli Affiliate: Stanley Prusiner | Authors: Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth and Carlo Condello | Summary: Down Syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among the complex clinical features including musculoskeletal, neurological and cardiovascular disabilities, […]
Kavli Affiliate: Edward Chang | Authors: Patrick W Hullett, Matthew K Leonard, Maria Luisa W Gorno-Tempini, Maria Luisa Mandelli and Edward F Chang | Summary: Models of speech perception are centered around a hierarchy in which auditory representations in the thalamus propagate to primary auditory cortex, then to the lateral temporal cortex, and finally through […]
Kavli Affiliate: Michael Keiser | Authors: Laura Shub, Wenjin Liu, Georgios Skiniotis, Michael J. Keiser and Michael J. Robertson | Summary: At sufficiently high resolution, x-ray crystallography and cryogenic electron microscopy are capable of resolving small spherical map features corresponding to either water or ions. Correct classification of these sites provides crucial insight for understanding […]
Kavli Affiliate: Anna Molofsky and Jeanne Paz | Authors: Nathan A. Ewing-Crystal, Nicholas M. Mroz, Anthony A. Chang, Eric Dean Merrill, Sofia E. Caryotakis, Leon Teo, Amara Larpthaveesarp, Tatsuya Tsukui, Aditya Katewa, Remy Pennington, Gabriel L. McKinsey, Sophia Nelson, Agnieszka Ciesielska, Madelene W. Dahlgren, Helena Paidassi, Saket Jain, Manish K. Aghi, James A. Bourne, Jeanne […]