Kavli Affiliate: Jeremy Willsey/p> | Authors: Kate E McCluskey, Katherine M Stovell, Karen Law, Elina Kostyanovskaya, James Schmidt, Cameron RT Exner, Jeanselle Dea, Elise Brimble, Matthew W State, A Jeremy Willsey and Helen Rankin Willsey | Summary: The comorbidity of autism spectrum disorders and severe gastrointestinal symptoms is well-established, yet the molecular underpinnings remain unknown. […]

Kavli Affiliate: Jin Kang | Authors: Alexandra Nelson and Anatol Kreitzer | Summary: Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. The activity of DA neurons is likely altered in PD, but we understand little about […]

Kavli Affiliate: Joshua Berke | Authors: Mariana Duhne, Ali Mohebi, Kyoungjun Kim, Lilian Pelattini and Joshua D. Berke; | Summary: Movement, motivation and reward-related learning depend strongly on striatal dopamine and acetylcholine. These neuromodulators each regulate the other, and disturbances to their coordinated signals contribute to human disorders ranging from Parkinson’s Disease to depression and […]

Kavli Affiliate: Loren Frank | Authors: Joshua P Chu, Michael E Coulter, Eric L. Denovellis, Trevor TK Nguyen, Daniel F Liu, Xinyi Deng, Uri T Eden, Caleb T Kemere and Loren M Frank | Summary: Decoding algorithms provide a powerful tool for understanding the firing patterns that underlie cognitive processes such as motor control, learning, […]

Kavli Affiliate: Kira Poskanzer | Authors: Xuelong Mi, Alex Bo-Yuan Chen, Daniela Duarte, Erin Carey, Charlotte R. Taylor, Philipp N. Braaker, Mark Bright, Rafael G. Almeida, Jing-Xuan Lim, Virginia M. Rutten, Wei Zheng, Mengfan Wang, Michael E. Reitman, Yizhi Wang, Kira E. Poskanzer, David A. Lyons, Axel Nimmerjahn, Misha B. Ahrens and Guoqiang Yu | […]

Kavli Affiliate: Kevin Yackle | Authors: Alastair MacDonald and Kevin Yacklei | Summary: Intonation in speech is the control of vocal pitch to layer expressive meaning to communication, like increasing pitch to indicate a question. Also, stereotyped patterns of pitch are used to create distinct “words”, like the ten sounds in the murine lexicon. A […]

Kavli Affiliate: Robert Edwards | Authors: Linzi Hosohama, Delia F. Tifrea, Kevin Nee, Sung Yun Park, Jie Wu, Amber N. Habowski, Cassandra Van, Marcus M. Seldin, Robert A. Edwards and Marian L. Waterman | Summary: Several classification systems have been developed to define tumor subtypes in colorectal cancer (CRC). One system proposes that tumor heterogeneity […]

Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Alexander Simon, Courtney Gallen, Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart-Harris and Christopher Timmermann | Summary: N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory […]