Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Arantxa Cebrian-Silla, Marcos Assis Nascimento, Walter Mancia Leon, Susana Gonzalez-Granero, Ricardo Romero-Rodriguez, Kirsten Obernier, David M Steffen, Daniel A Lim, Jose Manuel Garcia-Verdugo and Arturo Alvarez-Buylla | Summary: Neurogenesis and gliogenesis continue in the Ventricular-Subventricular Zone (V-SVZ) of the adult rodent brain. B1 cells are astroglial cells derived from […]

Kavli Affiliate: Saul Kato | Authors: Daniel Yutaka Sprague, Kevin Rusch, Raymond L Dunn, Jackson Borchardt, Greg Bubnis, Grace Chiu, Chentao Wen, Ryoga Suzuki, Shivesh Chaudhary, Ben Dichter, Ryan Ly, Shuichi Onami, Hang Lu, Kotaro Kimura, Eviatar I Yemini and Saul Kato | Summary: We develop a data harmonization approach for C. elegans volumetric microscopy […]

Kavli Affiliate: Daniel Minor | Authors: Shatabdi Roy-Chowdhury, Seil Jang, Fayal Abderemane-Ali, Fiona Naughton, Michael Grabe and Daniel L Minor, Jr. | Summary: The halothane-inhibited K2P leak potassium channel K2P13.1 (THIK-1)1–3 is found in diverse cells1,4 including neurons1,5 and microglia6–8 where it affects surveillance6, synaptic pruning7, phagocytosis7, and inflammasome-mediated interleukin-1β release6,8,9. As with many K2Ps1,5,10–14 […]

Kavli Affiliate: Yifan Cheng | Authors: Xi Liu, Yang Li, Lennice Castro, Zanlin Yu, Yifan Cheng, Matthew D Daugherty and John D Gross | Summary: ZYG11B is a substrate specificity factor for Cullin-RING ubiquitin ligase (CRL2) involved in many biological processes, including Gly/N-degron pathways. Yet how the binding of ZYG11B with CRL2 is coupled to […]

Kavli Affiliate: Yuh Nung and Jan Yifan Cheng and Yuh Nung Jan | Authors: Yukun Wang, Peng Jin, Avinash Kumar, Lily Jan, Yifan Cheng, Yuh-Nung Jan and Yongli Zhang | Summary: TCytoskeleton-tethered mechanosensitive channels (MSCs) utilize compliant proteins or protein domains called gating springs to convert mechanical stimuli into electric signals, enabling sound and touch […]

Kavli Affiliate: Devanand Manoli | Authors: Kimberly Lorraine Page Long, Nerissa Emmy Graetz Hoglen, Alex J. Keip, Robert M. Klinkel, Déjenaé L. See, Joseph Maa, Jenna C. Wong, Michael Sherman and Devanand Manoli | Summary: The formation of enduring relationships dramatically influences future behavior, promoting affiliation between familiar individuals. How such attachments are encoded to […]

Kavli Affiliate: Su Guo | Authors: Xiang Zhao, Wang Yiqi, Ahmet Can Solak, Jason Garcia, Vincent Mouilleau, Xingye Chen, Christopher J Wilkinson, Loic Alain Royer, Zhiqiang Alain Dong and Su Guo | Summary: Vertebrate radial glia progenitors (RGPs), the principal neural stem cells, balance self-renewal and differentiation through asymmetric cell division (ACD), during which unequal […]

Kavli Affiliate: Reza Abbasi Asl | Authors: Alex Jihun Lee, Shenqin Yao, Nicholas Lusk, Hongkui Zeng, Bosiljka Tasic and Reza Abbasi-Asl | Summary: Technologies such as spatial transcriptomics offer unique opportunities to define the spatial organization of the mouse brain. We developed an unsupervised training scheme and novel transformer-based deep learning architecture to detect spatial […]

Kavli Affiliate: Jeremy Willsey/p> | Authors: Kate E McCluskey, Katherine M Stovell, Karen Law, Elina Kostyanovskaya, James Schmidt, Cameron RT Exner, Jeanselle Dea, Elise Brimble, Matthew W State, A Jeremy Willsey and Helen Rankin Willsey | Summary: The comorbidity of autism spectrum disorders and severe gastrointestinal symptoms is well-established, yet the molecular underpinnings remain unknown. […]

Kavli Affiliate: Jin Kang | Authors: Alexandra Nelson and Anatol Kreitzer | Summary: Parkinson’s disease (PD) is characterized by the death of substantia nigra (SNc) dopamine (DA) neurons, but the pathophysiological mechanisms that precede and drive their death remain unknown. The activity of DA neurons is likely altered in PD, but we understand little about […]