Kavli Affiliate: Lily Jan | Authors: Kunal Shroff, Molly C O’Brien, Tyler J Smith, Jialing Fang, Kelly S Yu, Sonia I Lombroso, Shengjie Feng, Chao Chen, Gregory A Mohl, Indigo V L Rose, Nidhi R Lokesh, Mark E Pownall, Lily Y Jan and Martin Kampmann | Summary: Neuronal synapses are eliminated during brain development and […]
Kavli Affiliate: Bjoern Schwer | Authors: Joseph A Stewart, Jeanmarie Mishler, Samreen Ahmed, Bjoern Schwer, Thomas W. Glover and Thomas E Wilson | Summary: High-fidelity detection of rare structural variants (SVs) remains challenging because library preparation and sequencing techniques generate artifactual junctions that obscure true single-molecule events. Here, we present HiFiRe3, an error-minimized sequencing framework […]
Kavli Affiliate: Alexandra Nelson | Authors: Emily L Twedell, Chloe J Bair-Marshall, Allison E Girasole, Lara K Scaria, Sadhana Sridhar and Alexandra B Nelson | Summary: Striatal medium spiny neurons (MSNs) integrate convergent cortical, thalamic, and dopaminergic inputs to shape motor output. In addition, MSNs form local inhibitory synaptic connections with one another. The function […]
Kavli Affiliate: Yifan Cheng | Authors: Makoto Nakamura, Xiaoxin Chen, Shun Yao, Lynette Xin Chan, Ruan Hongmei, Alexis Boulinguiez, Nav Lally, Hao Wu, Kara Kodani, Kentaro Hirose, James Pirruccello, Alberto Malerba, Yifan Cheng, Vasanth Vedantham, Longzhi Tan, Jeffrey E. Olgin, Di Lang and Guo N. Huang | Summary: Three-dimensional genome organization stabilizes cell-type-specific gene expression, […]
Kavli Affiliate: Yuh Nung Jan | Authors: Adeline J.H. Yong, Yayu Wang, Juan A. Oses-Prieto, Tong Cheng, Chao Chen, Lane Domke, Mario V. Zubia, Jeffrey Simms, Alma L. Burlingame, Lily Y. Jan, Nicholas T. Ingolia, J. Wren Kim and Yuh Nung Jan | Summary: Synapses are dynamic structures whose protein composition remodels in response to […]
Kavli Affiliate: Edward Chang | Authors: Jeremy Saal, Ankit N. Khambhati, Edward F. Chang and Prasad Shirvalkar | Summary: Chronic pain engages distributed cortical and subcortical circuits, and large-scale intracranial recordings in humans offer a valuable opportunity to characterize its neural signatures. Here, we recorded multi-day stereoelectroencephalography (sEEG) from six participants with refractory chronic neuropathic […]
Kavli Affiliate: David Rowitch | Authors: Guy LAM, Zhaoyang Xu, Adrien M Vaquie, Stavros Vagionitis, Michael Perry, Omar de Faria, Jr., Georgios Solomou, John H Stockley, Gemma C Girdler, Daniel Yamamoto, Juan A Oses, Qianqian Zhang, Gregory Jordan, Laura R Morcom, Jacob Stillman, Hani S Mousa, Alma Burlingame, Murray Stewart, Hauke B. Werner, Andras Lakatos, […]
Kavli Affiliate: Zachary Knight | Authors: Alejandro Lopez-Cruz, Natalie S. Figueredo Burgos, Anna M Hakimi, Kathryn Xie, Mo Mao, Mahekdeep Kaur, Antionette Spina, Katie Choi, Longhui Qui, Teresa E Lever, Fiona M Gribble, Frank Reimann, Martin G Myers, Alice E Adriaenssens and Zachary A Knight | Summary: Nausea arises from activation of specialized neurons in […]
Kavli Affiliate: Karunesh Ganguly | Authors: Ryan Golden, Mingxiao Wei, Samantha Coury, Aviv Mizrahi-Kliger, Karunesh Ganguly and Maxim Bazhenov | Summary: Sleep supports both the consolidation of new memories and the forgetting of others, but how the cortex flexibly controls these outcomes remains poorly understood. Recent work has shown that two types of Up states […]
Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Bart A Eijkelkamp, Timothy R Cavagnaro, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Garth Harmsworth, Damien J Keating, Robert A Edwards and Martin F Breed | Summary: Global change profoundly impacts microbial systems but cascading effects on human metabolic health remain largely unexplored. Type 2 […]