Kavli Affiliate: Alexandra Nelson | Authors: Olivia K Barnhill, Kasandra M Romo and Alexandra B Nelson | Summary: Dystonia is a common movement disorder characterized by involuntary co-contraction of antagonist muscles, resulting in abnormal postures. The brain often appears grossly normal, suggesting dysfunctional neural activity as a cause. The basal ganglia are implicated in dystonia, […]

Kavli Affiliate: Robert Edwards | Authors: Nikolas Bergum, Andrew Yee, Robert Edwards and Christopher P. Ford | Summary: Accumulation of wild-type α-synuclein in dopamine neurons of the Substantia Nigra pars compacta (SNc) is a pathological hallmark of Parkinson’s disease (PD), which commonly precedes neurodegeneration. Yet how α-synuclein accumulation affects nigrostriatal neurotransmission early in the progression of PD […]

Kavli Affiliate: Karunesh Ganguly | Authors: Aviv D Mizrahi-Kliger, Samantha Coury, Cameron L Woodard and Karunesh Ganguly | Summary: With practice, rapid early gains in performance are followed by a slower phase marked by kinematic refinement, automaticity and enhanced cortical and striatal interactions. While sleep is known to support early learning, its causal role in […]

Kavli Affiliate: Stanley Prusiner | Authors: Nicholas L. Yan, Mylan Mayer, Arthur A. Melo, Jacob I. Ayers, Daniel A. Mordes, William W. Seeley, Stanley B. Prusiner, Eric Tse, Vinita G. Chittoor-Vinod and Gregory E Merz | Summary: α-Synuclein (aSyn) aggregation within Lewy bodies underlies Parkinson’s disease and associated dementias. These aggregates are often comprised of […]

Kavli Affiliate: Michael Stryker | Authors: Luciano Dyballa, Greg D Field, Michael P Stryker and Steven W Zucker | Summary: A challenge in sensory neuroscience is understanding how populations of neurons operate in concert to represent diverse stimuli. To meet this challenge, we have created “encoding manifolds” that reveal the overall responses of brain areas […]

Kavli Affiliate: Robert Edwards | Authors: Revan H Katte, Junyu Liu, Yufan He, Bhishem Thakur, Xiao Huang, Jared Lindenberger, Wang Xu, Narendra Kumar Gonepudi, Yang Han, Katarzyna Janowska, Robert J. Edwards, Priyamvada Acharya and Maolin Lu | Summary: Peptide fusion inhibitors, an important class of antivirals, block viral entry by targeting fusion proteins required for […]

Kavli Affiliate: Joshua Berke | Authors: Mariana Duhne, Isabelle Gonzalez Montalvo, Chelsea S Zheng, Lilian Pelattini and Joshua D Berke | Summary: Impulsive and uncontrolled behaviors are associated with loss of parvalbumin-expressing striatal interneurons (PV+). To understand this microcircuit mechanism we compared spiking of five classes of identified neurons in sensorimotor striatum, as rats waited […]

Kavli Affiliate: Peter Walter | Authors: Asmita Pramanik, Siva Hariprasad Kurma, Zhiwei Wen, Hongyi Cai, Pierre-Christian Violet, Peter J. Walter, Tamar Demby, Oksana Gavrilova, Srinivas Pittala, Haressh Sajiir, Regina Umarova, Allison Wing, Yaron Rotman, Jurgen Wess and Kenneth A. Jacobson | Summary: Knockout of the UDP-glucose-activated P2Y14 receptor (P2Y14R) in adipocytes or whole-body has been reported […]