ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

Kavli Affiliate: Yifan Cheng | Authors: Hao Wu, Upneet Kaur, Chengmin Li, Elise N. Munoz, Geeta J. Narlikar and Yifan Cheng | Summary: ATP-dependent chromatin remodeling enzymes play central roles in genome regulation by mobilizing nucleosomes. All remodelers except for one, position their core ATPase at an internal nucleosome location, superhelical location (SHL) 2, and […]


Continue.. ATP-dependent reorientation on a nucleosome primes INO80 for DNA translocation

Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

Kavli Affiliate: Arturo Alvarez-Buylla and Arnold R. Kriegstein | Authors: Arantxa Cebrian-Silla, Fiona R Dale-Huang, Stephanie A Redmond, Carmen Elena Aragon Ortiz, Juan Morianos, Marcos Assis Nascimento, Zhenmeiyu Li, Cristina Guinto, Susana Gonzalez-Granero, Ricardo Romero-Rodriguez, Cathryn R Cadwell, Vicente Herranz-Perez, Jose Manuel Garcia-Verdugo, Arnold Kriegstein, Eric Huang and Arturo Alvarez-Buylla | Summary: Ependymal (E1) cells, […]


Continue.. Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

Coordination of turn-related activity in the superior colliculus with locomotor dynamics and hippocampal representations of possible futures

Kavli Affiliate: Massimo Scanziani and Loren Frank | Authors: Cameron Wilhite, Loren M. Frank and Massimo Scanziani | Summary: Turning left or right is a core element of animal navigation. Such turns occur in precise coordination with the ongoing stepping rhythm and require internal planning for the animal’s future path. The superior colliculus (SC) is […]


Continue.. Coordination of turn-related activity in the superior colliculus with locomotor dynamics and hippocampal representations of possible futures

Smells like γ-synchrony: Insula-prefrontal communication depends on γ-synchrony and supports modality-specific changes in behavioral strategies

Kavli Affiliate: Vikaas Sohal | Authors: Lara L. Hagopian, Aarron J. Phensy, Austin J. Gallagher and Vikaas S. Sohal | Summary: The prefrontal cortex is critical for many aspects of flexible behavior, but how it interacts with other brain regions to perform this function remains largely unknown. The insula is bidirectionally coupled with prefrontal cortex […]


Continue.. Smells like γ-synchrony: Insula-prefrontal communication depends on γ-synchrony and supports modality-specific changes in behavioral strategies

Semaphorin 3A promotes resilience of sleep and cognition to brain injury

Kavli Affiliate: Jeanne Paz | Authors: Deanna Necula, Yuliya Voskobiynyk, Srujana Poluri and Jeanne T. Paz | Summary: Chronic sleep disruption and cognitive deficits are debilitating long-term consequences of traumatic brain injury (TBI), yet the endogenous mechanisms that drive network-level recovery remain poorly understood. Here, we demonstrate that during the chronic phase post-injury, network oscillations […]


Continue.. Semaphorin 3A promotes resilience of sleep and cognition to brain injury

A Neuroendocrine Circuit That Suppresses Excretion and Pelvic Pain During Activity

  Kavli Affiliate: Xin Duan | Authors: Lucas E Cabrera-Zapata, Archana Venkataraman, Andrea M Harrington, Jitao Hu, Fernanda Castro-Navarro, Kristina Galatsis, Xin Duan, Stuart M Brierley, Kimberly Keil Stietz and Holly A. Ingrahamber | Summary: Mate-seeking during peak sexual receptivity is tightly coupled with exploratory movement, a process made more efficient by transient suppression of […]


Continue.. A Neuroendocrine Circuit That Suppresses Excretion and Pelvic Pain During Activity

Parallel Opposing GABAergic Pallidothalamic Pathways

  Kavli Affiliate: Jeanne Paz | Authors: Isaac Y.M. Chang and Jeanne T. Paz | Summary: Coordinated movement relies on interactions between the basal ganglia and the thalamus, yet the circuits linking these structures are not fully understood. Here, we dissect a non-canonical basal ganglia output pathway, from the external globus pallidus (GPe) to the […]


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State-Dependent Organization of Microscale Functional Circuitry in Visual Cortex

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Reza Abbasi Asl | Authors: Rahul Biswas, Hasika Wickrama Senevirathne, Yujing Wang, Jiang Zhang, Somabha Mukherjee and Reza Abbasi-Asl | Summary: How the cortex organizes directed functional interactions among individual neurons and how this microscale circuitry maps onto cell types […]


Continue.. State-Dependent Organization of Microscale Functional Circuitry in Visual Cortex

Single-library chromosome-scale diploid assemblies of vole genomes resolve a species-specific duplication implicated in pair bonding

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Devanand Manoli | Authors: Mohamed Abuelanin, Gulhan Kaya, Juniper A Lake, Christine Lambert, Melody V Wu, Kristen Berendzen, Ksenia Krasheninnikova, Jonathan MD Wood, Nancy G Solomon, Zoe R Donaldson, Karen L Bales, Kerstin Howe, Jonas Korlach, Devanand S Manoli, Jessica […]


Continue.. Single-library chromosome-scale diploid assemblies of vole genomes resolve a species-specific duplication implicated in pair bonding

Disruption of theta-timescale spiking impairs learning but spares hippocampal replay

Kavli Affiliate: Loren Frank | Authors: Abhilasha Joshi, Alison E. Comrie, Samuel Bray, Abhijith Mankili, Jennifer A. Guidera, Rhino Nevers, Xulu Sun, Emily Monroe, Viktor Kharazia, Ryan Ly, Daniela Astudillo Maya, Denisse Morales-Rodriguez, Jai Yu, Anna Kiseleva, Victor Perez and Loren M. Frank | Summary: The ability to rapidly learn and retrieve salient information about […]


Continue.. Disruption of theta-timescale spiking impairs learning but spares hippocampal replay