Stacked binding of a small molecule PET tracer to Alzheimer’s tau paired helical filaments

Kavli Affiliate: Stanley Prusiner | Authors: Gregory E. Merz, Matthew J. Chalkley, Sophia Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner, Nick A. Paras, William F. DeGrado and Daniel R. Southworth | Summary: Abstract Neurodegenerative diseases (NDs) are characterized by the formation of amyloid filaments that adopt disease-specific conformations in the brain. Recently developed small […]


Continue.. Stacked binding of a small molecule PET tracer to Alzheimer’s tau paired helical filaments

Transient, developmental exposure to patient-derived anti-NMDA receptor autoantibodies causes long-term axonal and behavioral defects

Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: Abstract NMDA receptor autoimmune encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause behavioral and neurologic deficits. Although many symptoms are responsive to immunotherapy, […]


Continue.. Transient, developmental exposure to patient-derived anti-NMDA receptor autoantibodies causes long-term axonal and behavioral defects

Multi-areal neural dynamics encode human decision making

Kavli Affiliate: Edward Chang | Authors: Jacqueline A Overton, Karen A Moxon, Matthew P Stickle, Logan M Peters, Jack J Lin, Edward F Chang, Robert T Knight, Ming Hsu and Ignacio Saez | Summary: Abstract Value-based decision-making involves multiple cortical and subcortical brain areas, but the exact nature of neural activity underlying choice behavior has […]


Continue.. Multi-areal neural dynamics encode human decision making

Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

Kavli Affiliate: Kevin Bender | Authors: Selin Schamiloglu, Elinor Lewis, Anne C Hergarden, Kevin Bender and Jennifer L Whistler | Summary: ABSTRACT Second generation antipsychotics (SGAs) are front-line treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not others. The mechanisms underlying this unpredictability in treatment efficacy remain unclear. All […]


Continue.. Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

In silico discovery of repetitive elements as key sequence determinants of 3D genome folding

Kavli Affiliate: Michael Keiser | Authors: Laura M Gunsalus, Michael J. Keiser and Katherine S Pollard | Summary: Abstract Natural and experimental genetic variants can modify DNA loops and insulating boundaries to tune transcription, but it is unknown how sequence perturbations affect chromatin organization genome-wide. We developed an in silico deep-learning strategy to quantify the […]


Continue.. In silico discovery of repetitive elements as key sequence determinants of 3D genome folding

Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression

Kavli Affiliate: Hana El-Samad | Authors: Lindsey C Osimiri, Alain R Bonny, Seesha R Takagishi, Stefanie Luecke, Nina Riehs, Alexander Hoffmann and Hana El-Samad | Summary: Abstract Many transcription factors (TFs) translocate to the nucleus with varied dynamic patterns in response to different inputs. A notable example of such behavior is RelA, a subunit of […]


Continue.. Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression

Coordinated cadherin functions sculpt respiratory motor circuit connectivity

Kavli Affiliate: Xin Duan | Authors: Alicia N Vagnozzi, Matthew T Moore, Minshan Lin, Elyse M Brozost, Ritesh KC, Aambar Agarwal, Lindsay A Schwarz, Xin Duan, Niccolò Zampieri, Lynn T Landmesser and Polyxeni Philippidou | Summary: Abstract Breathing, and the motor circuits that control it, are essential for life. At the core of respiratory circuits […]


Continue.. Coordinated cadherin functions sculpt respiratory motor circuit connectivity

Production of brain-derived neurotrophic factor gates plasticity in developing visual cortex

Kavli Affiliate: Michael Stryker | Authors: Megumi Kaneko and Michael P Stryker | Summary: Abstract We have previously shown that recovery of visual responses to a deprived eye during the critical period in mouse primary visual cortex (V1) requires both export of mRNA encoding brain derived neurotrophic factor (BDNF) to the dendrites of cortical cells […]


Continue.. Production of brain-derived neurotrophic factor gates plasticity in developing visual cortex

Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

Kavli Affiliate: Robert Edwards | Authors: Fei Li, Jacob Eriksen, Juan A Oses-Prieto, Yessica K Gomez, Hongfei Xu, Janet Finer-Moore, Phuong Nguyen, Alisa Bowen, Andrew Nelson, Alma Burlingame, Michael Grabe, Robert Stroud and Robert Edwards | Summary: Abstract Concentration of neurotransmitter inside synaptic vesicles (SVs) underlies the quantal nature of synaptic transmission. In contrast to […]


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Neuronal Activity Alters Neuron to OPC Synapses

Kavli Affiliate: Samuel Pleasure | Authors: Daniela S Moura, Alekhya Parvathaneni, Atehsa Sahagun, Hirofumi Noguchi, Iris Tilton, Emma Brennan, Robert M Brock, Lindsay R. Halladay, Samuel J Pleasure and Laura A. Cocas | Summary: Abstract The mechanisms that drive the timing and specificity of oligodendrocyte myelination during development, or remyelination after injury or immune attack […]


Continue.. Neuronal Activity Alters Neuron to OPC Synapses