Kavli Affiliate: Arnold R. Kriegstein | Authors: Sajad Hamid Ahanger, Chujing Zhang, Evan R. Semenza, Eugene Gil, Mitchel A. Cole, Li Wang, Arnold R. Kriegstein and Daniel Lim | Summary: The nuclear genome is spatially organized into a three-dimensional (3D) architecture by physical association of large chromosomal domains with subnuclear compartments including the nuclear lamina […]
Kavli Affiliate: Jeremy Willsey | Authors: Nia Teerikorpi, Micaela C Lasser, Sheng Wang, Elina Kostyanovskaya, Ethel Bader, Nawei Sun, Jeanselle Dea, Tomasz J. Nowakowski, A Jeremy Willsey and Helen Willsey | Summary: Autism spectrum disorder (ASD) commonly co-occurs with congenital heart disease (CHD), but the molecular mechanisms underlying this comorbidity remain unknown. Given that children […]
Kavli Affiliate: Tejal Desai | Authors: Darnell L Cuylear, Moyu L Fu, Justin C Chau, Bhushan Kharbikar, Galateia Kazakia, Andrew Jheon, Stefan Habelitz, Sunil D Kapila and Tejal A Desai | Summary: Orthodontic relapse is one of the most prevalent concerns of orthodontic therapy. Relapse results in patients’ teeth reverting towards their pretreatment positions, which […]
Kavli Affiliate: Philip Starr | Authors: Natalya Slepneva, Genevieve Basich-Pease, Lee Reid, Adam C Frank, Tenzin Norbu, Andrew D Krystal, Leo P Sugrue, Julian C Motzkin, Paul S Larson, Philip A Starr, Melanie A Morrison and A Moses Lee | Summary: Background Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) […]
Kavli Affiliate: Edward Chang | Authors: Ting Qi, Maria Luisa Mandelli, Christa L. Watson Pereira, Emma Wellman, Rian Bogley, Abigail E. Licata, Edward F. Chang, Yulia Oganian and Maria Luisa Gorno-Tempini | Summary: Developmental dyslexia (DD) is typically associated with difficulties in manipulating speech sounds and, sometimes, in basic auditory processing. However, the neuroanatomical correlates […]
Kavli Affiliate: Andrea Hasenstaub | Authors: Calvin T Foss, Timothy Olsen, James Bigelow and Andrea R Hasenstaub | Summary: GABAergic interneurons, including somatostatin (SST) and vasoactive intestinal peptide (VIP) positive cells, play a crucial role in cortical circuit processing. Cre recombinase-mediated manipulation of these interneurons is facilitated by commercially available knock-in mouse strains such as […]
Kavli Affiliate: Seth Shipman | Authors: Kate D. Crawford, Asim G. Khan, Santiago C. Lopez, Hani Goodarzi and Seth Shipman | Summary: The bacterial retron reverse transcriptase system has served as an intracellular factory for single-stranded DNA in many biotechnological applications. In these technologies, a natural retron non-coding RNA (ncRNA) is modified to encode a […]
Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Arantxa Cebrian-Silla, Marcos Assis Nascimento, Walter Mancia Leon, Susana Gonzalez-Granero, Ricardo Romero-Rodriguez, Kirsten Obernier, David M Steffen, Daniel A Lim, Jose Manuel Garcia-Verdugo and Arturo Alvarez-Buylla | Summary: Neurogenesis and gliogenesis continue in the Ventricular-Subventricular Zone (V-SVZ) of the adult rodent brain. B1 cells are astroglial cells derived from […]
Kavli Affiliate: Saul Kato | Authors: Daniel Yutaka Sprague, Kevin Rusch, Raymond L Dunn, Jackson Borchardt, Greg Bubnis, Grace Chiu, Chentao Wen, Ryoga Suzuki, Shivesh Chaudhary, Ben Dichter, Ryan Ly, Shuichi Onami, Hang Lu, Kotaro Kimura, Eviatar I Yemini and Saul Kato | Summary: We develop a data harmonization approach for C. elegans volumetric microscopy […]
Kavli Affiliate: Daniel Minor | Authors: Shatabdi Roy-Chowdhury, Seil Jang, Fayal Abderemane-Ali, Fiona Naughton, Michael Grabe and Daniel L Minor, Jr. | Summary: The halothane-inhibited K2P leak potassium channel K2P13.1 (THIK-1)1–3 is found in diverse cells1,4 including neurons1,5 and microglia6–8 where it affects surveillance6, synaptic pruning7, phagocytosis7, and inflammasome-mediated interleukin-1β release6,8,9. As with many K2Ps1,5,10–14 […]