Cell Cycle Arrest of a “Zippering” Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders

Kavli Affiliate: Georgia Panagiotakos | Authors: Tiange Qu, Brandon H Chacon, Louis Faure, Marta Losa, Rocio Hernandez-Martinez, Kelsey Robinson, Aragorn Jones, Steven Lisgo, Maurizio Risolino, Jaiden De Anda, Georgia Panagiotakos, Elizabeth J Leslie-Clarkson, Igor Adameyko and Licia Selleri | Summary: Facial features identify individuals, but the mechanisms shaping the human face remain elusive. Orofacial clefting […]


Continue.. Cell Cycle Arrest of a “Zippering” Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders

Synteny-aware functional annotation of bacteriophage genomes with Phynteny

Kavli Affiliate: Robert Edwards | Authors: Susanna R Grigson, George Bouras, Bhavya Papudeshi, Vijini Mallawaarachchi, Michael J Roach, Przemyslaw Decewicz and Robert A Edwards | Summary: Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophage biology; yet, the majority of bacteriophage genes remain functionally uncharacterised. Bacteriophage genomes often exhibit conserved gene order, […]


Continue.. Synteny-aware functional annotation of bacteriophage genomes with Phynteny

Hippocampal input-driven plasticity of prefrontal interneurons reveals a circuit basis for impaired spatial working memory.

Kavli Affiliate: Vikaas Sohal | Authors: Shana E Silverstein, Thomas T Clarity, Meena S Deshpande, Erik Vaughan, Shoshana Novik, Hector E Yarur, Shiliang Zhang, Valerie S Tsai, Rong Ye, Rachel M Mikofsky, Madeline Hsiang, Avery Bauman, Gabriel Loewinger, Francisco Pereira, Marisela Morales, Vikaas S Sohal, Hugo Tejeda, Joshua A Gordon and David A Kupferschmidt | […]


Continue.. Hippocampal input-driven plasticity of prefrontal interneurons reveals a circuit basis for impaired spatial working memory.

Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro

Kavli Affiliate: Tejal Desai | Authors: Qinghe Zeng, Landon Flemming, Yuanzhou Chen, Thomas Mazumder, Heinz Hammerlindl, Greg M. Allen, Ricardo Almeida, Jasper Z. Williams, Rogelio A. Hernandez-Lopez, Justin Eyquem, Chun Jimmie Ye, Wendell A Lim, Qizhi Tang, Tejal Desai and Xiao Huang | Summary: T cell proliferative capacity and persistence critically determine the therapeutic success […]


Continue.. Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro

Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

Kavli Affiliate: Robert Edwards | Authors: Hannelore Longin, George Bouras, Susanna R. Grigson, Robert A. Edwards, Hanne Hendrix, Rob Lavigne and Vera van Noort | Summary: Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, to date, only a […]


Continue.. Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

Non-visual light modulates behavioral memory and gene expression in C. elegans

Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]


Continue.. Non-visual light modulates behavioral memory and gene expression in C. elegans

Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering

Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Laura Bonillo-Lopez, Milo S Johnson, Nastassia Knoedlseder, Ching-Chung Ko, Yassir Lekbach, Jee-Hwan Oh, Hemaa Selvakumar, Michael C Wold, Zihan Yu, Virginia Aragon, Jeffrey A Gralnick, Marc Guell, Graham Hatfull, Benjamin Keith Keitz, Britt Koskella, Vivek K Mutalik, Jan Peter van Pijkeren and Seth Shipman | Summary: Advanced […]


Continue.. Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering

Electrocorticographic Detection of Speech Networks in Glioma-infiltrated Cortex

Kavli Affiliate: Edward Chang | Authors: Vardhaan S Ambati, Amit S Persad, Jasleen Kaur, Sanjeev Herr, Emily Cunningham, Abraham Dada, Justyna O Ekert, Quinn Greicius, Alexander Silva, Paul McMillan Villalobos, Niels Olshausen, Youssef Sibih, Sena Oten, Hunter S. Yamada, Gray Umbach, Alexander A Aabedi, Wajd Al-Holou, Jacob Young, Madhumita Sushil, Edward F Chang, Mitchel S. […]


Continue.. Electrocorticographic Detection of Speech Networks in Glioma-infiltrated Cortex

Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia

Kavli Affiliate: Su Guo | Authors: Krishnashish Bose, Su Guo and Karnika Bhardwaj | Summary: Paradoxical kinesia—the temporary alleviation of motor deficits by powerful, urgent stimuli in Parkinson’s disease (PD)—remains poorly understood at the neural circuit level. Through chemo-genetic ablation of tyrosine hydroxylase-expressing neurons in larval zebrafish and brain-wide calcium imaging under head-fixed, tail-free conditions, […]


Continue.. Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia

Photothrombotic Ischemic Thalamic Stroke in Mice Recapitulates Spontaneous Pain Features of Central Post-Stroke Pain in Humans

Kavli Affiliate: Jeanne Paz | Authors: Jeremy B Ford, Olive N Tambou, Jarret AP Weinrich, Debleena Chatterjee, Allan Basbaum and Jeanne T. Paz | Summary: Central post-stroke pain (CPSP) is a highly distressing condition that develops in 50% of people who suffer a thalamic stroke, and is typically unresponsive to current clinical treatments. Hypoxic damage […]


Continue.. Photothrombotic Ischemic Thalamic Stroke in Mice Recapitulates Spontaneous Pain Features of Central Post-Stroke Pain in Humans