Kavli Affiliate: Yifan Cheng | Authors: William Randall Arnold, Adamo S Mancino, Frank R Moss III, Adam Frost, David Julius and Yifan Cheng | Summary: TRP ion channels are modulated by phosphoinositide lipids, but the underlying structural mechanisms remain unclear. The capsaicin- and heat-activated receptor, TRPV1, has served as a model for deciphering lipid modulation, […]
Kavli Affiliate: Robert J Edwards | Authors: Brenda Kapingidza, Daniel J Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schaefer, Amanda Eaton, Justine Mae Flores, Austin Hamer, Nicholas J Cantazaro, Jr., Michael L Mallory, Melissa D Mattocks, Christopher Berverly, Brianna Rhodes, […]
Kavli Affiliate: Lisa Gunaydin | Authors: Teagan E Bullock and Lisa A. Gunaydin | Summary: Active avoidance is a fundamental defensive behavior, defined as performing a voluntary action to escape a noxious stimulus. Active avoidance serves as an adaptive response to threat, ensuring safety. In individuals with anxiety disorders and post-traumatic stress disorder, avoidance behavior […]
Kavli Affiliate: Arnold R. Kriegstein | Authors: Dmitry Velmeshev, Yonatan Perez, Zihan Yan, Jonathan E Valencia, David R Castaneda-Castellanos, Li Wang, Lucas Schirmer, Simone Mayer, Brittney Wick, Shaohui Wang, Tomasz J. Nowakowski, Mercedes Paredes, Eric J. J. Huang and Arnold Kriegstein | Summary: We analyze more than 700,000 single-nucleus RNA-seq profiles from 106 donors during […]
Kavli Affiliate: Robert Edwards | Authors: Vijini Mallawaarachchi, Michael J. Roach, Przemyslaw Decewicz, Bhavya Papudeshi, Sarah K Giles, Susanna R Grigson, George Bouras, Ryan D Hesse, Laura K Inglis, Abbey LK Hutton, Elizabeth A Dinsdale and Robert A Edwards | Summary: Microbial communities influence both human health and different environments. Viruses infecting bacteria, known as […]
Kavli Affiliate: Peter Walter | Authors: Rochelle Coulson, Valentina Frattini, Caitlin Moyer, Jennifer Hodges, Peter Walter, Philippe Mourrain, Yi Zuo and Gordon Wang | Summary: Fragile X syndrome (FXS) is caused by the functional loss of Fragile X messenger ribonucleoprotein (FMRP), a translational regulator that binds the transcripts of many proteins involved in synaptic function […]
Kavli Affiliate: Xin Duan | Authors: Wendy W.S. Yue, Kouki K. Touhara, Kenichi Toma, Xin Duan and David Julius | Summary: After injury, mammalian spinal cords develop scars to seal off the damaged area and prevent further injury. However, excessive scarring can hinder neural regeneration and functional recovery (1, 2). These competing actions underscore the […]
Kavli Affiliate: Joshua Berke | Authors: Thomas Faust, Ali Mohebi and Joshua D Berke | Summary: The nucleus accumbens (NAc) helps govern motivation to pursue rewards. Two distinct sets of NAc projection neurons – expressing dopamine D1 versus D2 receptors – are thought to promote and suppress motivated behaviors respectively. However, support for this conceptual […]
Kavli Affiliate: Bjoern Schwer | Authors: Christin Schmidt, Sarah Cohen, Brian L. Gudenas, Sarah Husain, Annika Carlson, Samantha Westelman, Linyu Wang, Joanna J. Phillips, Paul A. Northcott, William A. Weiss and Bjoern Schwer | Summary: SNCAIP duplication may promote Group 4 medulloblastoma via induction of PRDM6, a poorly characterized member of the PRDF1 and RIZ1 […]
Kavli Affiliate: Su Guo | Authors: Jiale Xu, Romelo Casanave, Apurva S Chitre, Qiyang Wang, Khai-Minh Nguyen, Chiara Blake, Mahendra Wagle, Riyan Cheng, Oksana Polesskaya, Abraham A Palmer and Su Guo | Summary: Behavioral diversity is critical for population fitness. Individual differences in risk-taking are observed across species, but underlying genetic mechanisms and conservation are […]