Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Yajun Xie, Christopher M Reid, Alejandro A Granados, Miguel Turrero Garcia, Fiona Dale-Huang, Sarah M Hanson, Walter R Mancia Leon, Jonathan Liu, Manal A Adam, Olivia Mosto, Angela Oliveira Pisco, Arturo Alvarez-Buylla and Corey C Harwell | Summary: Astrocyte specification during development is influenced by both intrinsic and extrinsic […]
Kavli Affiliate: Michael Stryker | Authors: Wendy Xin, Megumi Kaneko, Richard H Roth, Albert Zhang, Sonia Nocera, Jun B Ding, Michael P Stryker and Jonah R Chan | Summary: BACKGROUND: Developmental myelination is a protracted process in the mammalian brain. One theory for why oligodendrocytes mature so slowly posits that myelination may stabilize neuronal circuits […]
Kavli Affiliate: Reza Abbasi Asl | Authors: Robert Cahill, Yu Wang, Alex Lee, Hongkui Zeng, Bin Yu, Bosiljka Tasic and Reza Abbasi-Asl | Summary: The growth of large-scale spatial gene expression data requires new computational tools to extract major trends in gene expression in their native spatial context. Here, we describe an unsupervised and interpretable […]
Kavli Affiliate: Philip Starr | Authors: Bahman Abdi-Sargezeh, Sepehr Shirani, Abhinav Sharma, Philip Starr, Simon Little and Ashwini Oswal | Summary: Neural activities within the beta frequency range (13-30 Hz) are not stationary, but occur in transient packets known as beta bursts. Parkinson’s disease (PD) is characterized by the occurrence of beta bursts of increased […]
Kavli Affiliate: Arnold R. Kriegstein | Authors: Yonatan Perez, Dmitry Velmeshev, Li Wang, Matthew White, Clara Siebert, Jennifer Baltazar, Natalia Garcia Dutton, Shaohui Wang, Maximilian Haeussler, Stormy Chamberlain and Arnold Kriegstein | Summary: Duplication 15q (dup15q) syndrome is the most common genetic cause of autism spectrum disorder (ASD). Due to a higher genetic and phenotypic […]
Kavli Affiliate: Yifan Cheng | Authors: William Randall Arnold, Adamo S Mancino, Frank R Moss III, Adam Frost, David Julius and Yifan Cheng | Summary: TRP ion channels are modulated by phosphoinositide lipids, but the underlying structural mechanisms remain unclear. The capsaicin- and heat-activated receptor, TRPV1, has served as a model for deciphering lipid modulation, […]
Kavli Affiliate: Robert J Edwards | Authors: Brenda Kapingidza, Daniel J Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schaefer, Amanda Eaton, Justine Mae Flores, Austin Hamer, Nicholas J Cantazaro, Jr., Michael L Mallory, Melissa D Mattocks, Christopher Berverly, Brianna Rhodes, […]
Kavli Affiliate: Lisa Gunaydin | Authors: Teagan E Bullock and Lisa A. Gunaydin | Summary: Active avoidance is a fundamental defensive behavior, defined as performing a voluntary action to escape a noxious stimulus. Active avoidance serves as an adaptive response to threat, ensuring safety. In individuals with anxiety disorders and post-traumatic stress disorder, avoidance behavior […]
Kavli Affiliate: Arnold R. Kriegstein | Authors: Dmitry Velmeshev, Yonatan Perez, Zihan Yan, Jonathan E Valencia, David R Castaneda-Castellanos, Li Wang, Lucas Schirmer, Simone Mayer, Brittney Wick, Shaohui Wang, Tomasz J. Nowakowski, Mercedes Paredes, Eric J. J. Huang and Arnold Kriegstein | Summary: We analyze more than 700,000 single-nucleus RNA-seq profiles from 106 donors during […]
Kavli Affiliate: Robert Edwards | Authors: Vijini Mallawaarachchi, Michael J. Roach, Przemyslaw Decewicz, Bhavya Papudeshi, Sarah K Giles, Susanna R Grigson, George Bouras, Ryan D Hesse, Laura K Inglis, Abbey LK Hutton, Elizabeth A Dinsdale and Robert A Edwards | Summary: Microbial communities influence both human health and different environments. Viruses infecting bacteria, known as […]