eIF2B Selectively Anchors and Activates Mutant KRAS

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Peter Walter | Authors: Hyungdong Kim, Shiqi Diao, Kwang-Jin Cho, Hyun-Ro Lee, Junchen Liu, Pascal Egea, Tatu Pantsar, Milla Kurki, Nour Ghaddar, Shuo Wang, Jia Yi Zou, Mehdi Amiri, Ritchel Gannaban, John F. Hancock, Kylie M Rice, Qiyun Deng, Atsuo […]


Continue.. eIF2B Selectively Anchors and Activates Mutant KRAS

Atypical developmental remodeling of dopamine neurons involves AKT-GSK3β signaling and glia activity

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Lily Jan and Yuh Nung Jan | Authors: Xiaofan Zhang, Wei Chen, Yayu Wang, Xun Tu, Xiangyu Zhang, Ronald L. Davis, Lily Yeh Jan and Yuh Nung Jan | Summary: Neuronal remodeling is essential for sculpting neural circuits, and its […]


Continue.. Atypical developmental remodeling of dopamine neurons involves AKT-GSK3β signaling and glia activity

ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Alex Pollen | Authors: Matthew T. Schmitz, Jingwen W. Ding, Sara Nolbrant, Reed McMullen, Chang N. Kim, Bryan J. Pavlovic, Tomasz J. Nowakowski, Trygve E. Bakken, Chun Jimmie Ye and Alex Aaron Pollen | Summary: Diverse neurons and glia are […]


Continue.. ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain

Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

Kavli Affiliate: Xin Duan | Authors: Kriti Chaplot, Lin Zhang, Julia Wessman, Miguel Rivera, Zhihui Wang, Fei Wang, Xin Duan, Pamela M. England, Iain C. Clark and Erik M. Ullian | Summary: In vitro modelling of highly vulnerable nigral dopaminergic (DA) neuronal subtypes in Parkinson’s disease (PD), is necessary for studying disease mechanisms. Here, we […]


Continue.. Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

Reverse transcribed ssDNA derepresses translation of a retron antiviral protein

Kavli Affiliate: Seth Shipman | Authors: Karen Zhang, Matías Rojas-Montero, Darshini Poola, Josepha Klas, Arturo Carabias, Dennis Zhang, Mario R Mestre, Ruiliang Zhao, Ana Dávila-Hidalgo, Guillermo Montoya, Rafael Pinilla-Redondo, Alejandro González-Delgado and Seth L Shipman | Summary: Retrons are bacterial immune systems that prevent the spread of phages by initiating a toxic response within infected […]


Continue.. Reverse transcribed ssDNA derepresses translation of a retron antiviral protein

REM sleep predicts reductions in pathophysiological daytime basal ganglia-cortical circuit activity in Parkinson’s disease

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Philip Starr | Authors: Jin-Xiao Zhang, Clay Smyth, Hanna Cattan-Hayat, Md Fahim Anjum, Yue Leng, Andrew D. Krystal, Philip A. Starr and Simon Little | Summary: Sleep disturbances have been shown to be intimately and bidirectionally related to disease progression […]


Continue.. REM sleep predicts reductions in pathophysiological daytime basal ganglia-cortical circuit activity in Parkinson’s disease

Antibody Reveals Conformational Latch Controlling Herpesvirus Proteases

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Yifan Cheng | Authors: Marcell Zimanyi, Kaitlin R Hulce, Markus F Bohn, Jordan Norman, Peter J Rohweder, Yifan Cheng and Charles Craik | Summary: Human herpesviruses (HHVs) are widespread pathogens that cause severe disease. Their replication depends on the HHV […]


Continue.. Antibody Reveals Conformational Latch Controlling Herpesvirus Proteases

Sensorimotor Theta Oscillations Coordinate Speech Movements

Kavli Affiliate: Edward Chang and Loren Frank | Authors: Yitzhak Norman, Loren M. Frank and Edward F. Chang | Summary: Fluent speech depends on precisely timed motor commands that coordinate rapid transitions between successive articulatory gestures. Using direct cortical recordings, we identified a prominent sensorimotor theta oscillation (6–10 Hz) that supports this coordination. During articulation, […]


Continue.. Sensorimotor Theta Oscillations Coordinate Speech Movements

Ingestion-activated CGRP neurons control learning but not satiety

Kavli Affiliate: Zachary Knight | Authors: Brooke C Jarvie, Anagh Ravi, Rhea Nanavati, Longhui Qui, Truong Ly, Jun Y Oh, Olivia K Barnhill and Zachary A Knight | Summary: Calcitonin Gene-Related Peptide (CGRP) neurons in the parabrachial nucleus are critical for sickness and malaise but have also been proposed to control non-aversive (rewarding) satiation. How […]


Continue.. Ingestion-activated CGRP neurons control learning but not satiety

Cell-Intrinsic Vulnerability and Immune Activation Cooperate to Drive Degeneration in a Mitochondrial Complex I Deficiency Model of Optic Neuropathy

Kavli Affiliate: Xin Duan | Authors: Daniela Santamaria-Munoz, Raenier V. Reyes, Miranda R. Krueger, Andrea Garcia-Llorca, Brennan Marsh-Armstrong, Xin Duan, Yang Hu, Derek S. Welsbie, Nicholas Marsh-Armstrong, Elisenda Sanz, Albert Quintana, Sergi Simo and Anna La Torre | Summary: Mitochondrial dysfunction is a central hallmark of many optic neuropathies, yet the mechanisms linking intrinsic metabolic […]


Continue.. Cell-Intrinsic Vulnerability and Immune Activation Cooperate to Drive Degeneration in a Mitochondrial Complex I Deficiency Model of Optic Neuropathy