Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Kavli Affiliate: Robert Edwards | Authors: R. Dilshan Malewana, Victoria Stalls, Aaron May, Xiaozhi Lu, David R Martinez, Alexandra Schafer, Dapeng Li, Maggie Barr, Laura L Sutherland, Esther Lee, Robert Parks, Whitney Edwards Beck, Amanda Newman, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, C. Todd DeMarco, Thomas N Denny, Thomas H Oguin III, Wes […]


Continue.. Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli | Authors: Mukesh Kumar, Yumei Wu, Justin Knapp, Daehun Park, Kallol Gupta, Pietro De Camilli and Timothy A. Ryan | Summary: HSP54, a hereditary spastic paraplegia associated with cognitive impairment, is caused by mutations in the neuron-specific triglyceride (TG) lipase DDHD2. Loss of DDHD2 function results […]


Continue.. DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

Covalent Targeting of Splicing in T Cells.

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Charles D. Warren, Tiffany L. Zhang, Simon J. Hogg, Caroline Webster, Xiaoyu Zhang, Jahan Rahman, Bruno Melillo, Benjamin F. Cravatt, Jiankun Lyu, Omar Abdel-Wahab and Ekaterina V Vinogradova | Summary: Despite significant interest in therapeutic targeting of splicing, few chemical probes […]


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Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]


Continue.. Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

A reference genome for the Andean cavefish Trichomycterus rosablanca (Siluriformes, Trichomycteridae): building genomic resources to study evolution in cave environments

Kavli Affiliate: Erich Jarvis | Authors: Daniel Cadena, Laura Pabon, Carlos DoNascimiento, Linelle Abueg, Tatiana Tiley, Brian O-Toole, Dominic Absolon, Ying Sims, Giulio Formenti, Olivier Fedrigo, Erich Jarvis and Mauricio Torres | Summary: Animals living in caves are of broad relevance to evolutionary biologists interested in understanding the mechanisms underpinning convergent evolution. In the Eastern […]


Continue.. A reference genome for the Andean cavefish Trichomycterus rosablanca (Siluriformes, Trichomycteridae): building genomic resources to study evolution in cave environments

Glia detect and mount a protective response to loss of dendrite substructure integrity in C. elegans

Kavli Affiliate: Shai Shaham | Authors: Colin W Hoy, Coralie de Hemptinne, Sarah S Wang, Catherine J Harmer, Matthew A J Apps, Masud Husain, Philip A Starr and Simon Little | Summary: Neurons have elaborate structures that determine their connectivity and functions. Changes in neuronal structure accompany learning and memory formation and are hallmarks of […]


Continue.. Glia detect and mount a protective response to loss of dendrite substructure integrity in C. elegans

Ammonia-oxidizing archaea and bacteria differentially contribute to ammonia oxidation in soil under precipitation gradients and land legacy

Kavli Affiliate: Charles M. Rice | Authors: Soumyadev Sarkar, Anna Kazarina, Paige M. Hansen, Kaitlyn Ward, Christopher Hargreaves, Nicholas Reese, Qinghong Ran, Willow Kessler, Ligia F.T. de Souza, Terry D. Loecke, Marcos V.M. Sarto, Charles W. Rice, Lydia H. Zeglin, Benjamin A. Sikes and Sonny T.M. Lee | Summary: Global change has accelerated the nitrogen […]


Continue.. Ammonia-oxidizing archaea and bacteria differentially contribute to ammonia oxidation in soil under precipitation gradients and land legacy

Generation and characterization of a multi-functional panel of monoclonal antibodies for SARS-CoV-2 research and treatment

Kavli Affiliate: Charles M. Rice | Authors: Lila D. Patterson, Benjamin D. Dubansky, Brooke H. Dubansky, Shannon Stone, Mukesh Kumar and Charles D Rice | Summary: The Coronavirus disease 2019 (COVID19) pandemic caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is an ongoing threat to global public health. To this end, intense efforts are underway to […]


Continue.. Generation and characterization of a multi-functional panel of monoclonal antibodies for SARS-CoV-2 research and treatment

SELENOT regulates endoplasmic reticulum calcium flux via SERCA2 and maintains dopaminergic DAT to protect against attention deficit hyperactivity disorder in mice

Kavli Affiliate: Li Zhao | Authors: Qing Guo, Zhao-Feng Li, Dong-Yan Hu, Pei-Jun Li, Kai-Nian Wu, Hui-Hui Fan, Jie Deng, Hong-Mei Wu, Xiong Zhang and Jian-Hong Zhu | Summary: Attention deficit and hyperactivity disorder (ADHD) is a prevalent developmental disorder. SELENOT is an endoplasmic reticulum-resident selenocysteine-containing protein. We aimed to investigate the role of SELENOT […]


Continue.. SELENOT regulates endoplasmic reticulum calcium flux via SERCA2 and maintains dopaminergic DAT to protect against attention deficit hyperactivity disorder in mice

Male-male interactions shape mate selection in Drosophila

Kavli Affiliate: Vanessa Ruta | Authors: Tom Hindmarsh Sten, Rufei Li, Florian Hollunder, Shadé Eleazer and Vanessa Ruta | Summary: Males of many species have evolved behavioral traits to both attract females and repel rivals. Here, we explore mate selection in Drosophila from both the male and female perspective to shed light on how these […]


Continue.. Male-male interactions shape mate selection in Drosophila