Global molecular landscape of early MASLD progression in obesity

Kavli Affiliate: Li Zhao | Authors: Qing Zhao, William de Nardo, Ruoyu Wang, Yi Zhong, Umur Keles, Gabriele Sakalauskaite, Li Na Zhao, Huiyi Tay, Sonia Youhanna, Mengchao Yan, Ye Xie, Youngrae Kim, Sungdong Lee, Rachel Liyu Lim, Guoshou Teo, Pradeep Naraya, Paul R Burton, Volker M Lauschke, Hyungwon Choi, Matthew J Watt and Philipp Kaldis […]


Continue.. Global molecular landscape of early MASLD progression in obesity

Neuronal calcium spikes enable vector inversion in the Drosophila brain

Kavli Affiliate: Keri Martinowich | Authors: Jason J Rehg, Daniel E Olivares, Ye Li, Keri Martinowich, Greg V Carr and Jorge Miranda-Barrientos | Summary: A typical neuron signals to downstream cells when it is depolarized and firing sodium spikes. Some neurons, however, also fire calcium spikes when hyperpolarized. The function of such bidirectional signaling remains […]


Continue.. Neuronal calcium spikes enable vector inversion in the Drosophila brain

Molecular evolution of CO2-sensing ab1C neurons underlies divergent sensory responses in the Drosophila suzukii species group

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Li Zhao | Authors: Alice Gadau, Sasha Mills, Xin Yu Zhu Jiang, Cong Li, Nicolas Svetec, Ziyu Xu, Wanhe Li, Katherine I Nagel and Li Zhao | Summary: Organisms evolve behavioral and morphological traits to adapt to their ecological niches, […]


Continue.. Molecular evolution of CO2-sensing ab1C neurons underlies divergent sensory responses in the Drosophila suzukii species group

Discovery Stack Pilot: Feasibility and Outcomes of a Scientist-Designed Peer Review Model Separating Quality and Impact

Kavli Affiliate: Daniel Mucida | Authors: Maureen A McGargill, Beiyun C Liu, Michael S Kuhns, Daniel Mucida, Isabella Rauch, Lauren B Rodda, Meghan A Koch, Hugo Gonzalez Velozo, Ken Cadwell, Tanya S Freedman, Tiffany C Scharschmidt, Richard Sever, Jose Ordovas-Montanes, Andrew Oberst, Brooke Runnette and Matthew F Krummel | Summary: Peer review serves as the […]


Continue.. Discovery Stack Pilot: Feasibility and Outcomes of a Scientist-Designed Peer Review Model Separating Quality and Impact

Neural Synchrony Links Sensorimotor Cortices in a Network for Facial Motor Control

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Winrich Freiwald | Authors: Yuriria Vazquez, Geena R Ianni, Elie Rassi, Adam G Rouse, Marc H Schieber, Faraz Yazdani, Yifat Prut and Winrich A Freiwald | Summary: Primate societies rely on the production and interpretation of social signals, in particular […]


Continue.. Neural Synchrony Links Sensorimotor Cortices in a Network for Facial Motor Control

Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Daniel Mucida | Authors: Shaina L Carroll, Andrew Ly, Ashley K Liu, Maria C.C. Canesso, Gabriel D Victora, Daniel Mucida and Gregory M Barton | Summary: How the complex network of intestinal antigen presenting cells (APCs) instructs CD4+ T cell […]


Continue.. Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation

Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating

Kavli Affiliate: Roderick MacKinnon | Authors: George Vaisey and Roderick MacKinnon | Summary: Piezo1 ion channels are widely expressed cellular mechanosensors. They adopt an intrinsically curved shape when closed and are thought to open when mechanical forces applied to the membrane favor a more flattened conformation. By reconstituting Piezo1 channels into lipid vesicles, a flattened […]


Continue.. Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating

Exercise intensity modulates the human plasma secretome and interorgan communication

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Luke Olsen, Javier Botella, Douglas Barrows, Ethan Romero, Kaitlyn Baird, Mutsumi Katayama, Ece Kilic, Christopher Peralta, Henry Sanford, Laurie Farrell, Christopher L Axelrod, Kaja Plucinska, Jeanne Walker, Lu Yan, Katie Fredrickson, Olivier Pourquie, Jeremy M. Robbins, Ekaterina V Vinogradova, John P. Kirwan, Juleen R. Zierath, Anna Krook, Robert […]


Continue.. Exercise intensity modulates the human plasma secretome and interorgan communication

DNA methylation profiles in diabetic embryos

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Li Zhao | Authors: Pu-Yu Li, Fu-Li Zhao, Yi-Juan Song, Bing-Yao Lei, Hao-Jin Niu, Ying-Fang Wang and Hong-Wei Jiang | Summary: Maternal diabetes leads to neural tube defects (NTDs) in offspring. DNA methylation could be associated with NTDs induced by […]


Continue.. DNA methylation profiles in diabetic embryos

C. elegans astrocytes mature in two phases from lineally distinct progenitors through CEH-43/DLX-mediated convergent transcription

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Shai Shaham | Authors: Simin Liu, Kenneth Bradley, Jinghong J. Tang, Yoon A. Kim, Ana Milosevic and Shai Shaham | Summary: Astrocytic glia regulate brain assembly, synapse formation/activity, neuronal energetics, and brain metabolism. Gene programs driving astrocyte specification are only […]


Continue.. C. elegans astrocytes mature in two phases from lineally distinct progenitors through CEH-43/DLX-mediated convergent transcription