Kavli Affiliate: Stanislas Leibler | Authors: Pablo Sartori and Stanislas Leibler | Summary: One of the tenets of molecular biology is that dynamical transitions between three dimensional structures largely determine the function of individual proteins, as well as multi-protein assemblies. Therefore, it seems only natural that evolutionary analysis of proteins, presently based mainly on their […]

Kavli Affiliate: Li Zhao | Authors: Yuntao Yang, Yuhan Xie, Zhao Li, Chiamaka Diala, Meer Ali, Rongbin Li, Yi Xu, Albon Wu, Pora Kim, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao and W. Jim Zheng | Summary: Alternative splicing is an important cellular process in eukaryotes, altering pre-mRNA to yield multiple protein isoforms from a single […]

Kavli Affiliate: Roderick MacKinnon | Authors: Gonzalo Pérez-Mitta, Yeliz Sezgin, Weiwei Wang and Roderick MacKinnon | Summary: Abstract Integral membrane proteins (IMPs) constitute a large fraction of organismal proteomes, playing fundamental roles in physiology and disease. Despite their importance, the mechanisms underlying dynamic features of IMPs, such as anomalous diffusion, protein-protein interactions, and protein clustering, […]

Kavli Affiliate: Sidney Strickland | Authors: Pradeep K Singh, Elisa Nicoloso Simoes-Pires, Zu-Lin Chen, Daniel Torrente, Marissa Calvano, Anurag Sharma, Sidney Strickland and Erin H Norris | Summary: Proteinaceous brain inclusions, neuroinflammation, and vascular dysfunction are common pathologies in Alzheimer’s disease (AD). Vascular deficits include a compromised blood-brain barrier, which can lead to extravasation of […]

Kavli Affiliate: Alipasha Vaziri | Authors: Jason Manley, Jefferey Demas, Hyewon Kim, Francisca Martinez Traub and Alipasha Vaziri | Summary: The brain’s remarkable properties arise from collective activity of millions of neurons. Widespread application of dimensionality reduction to multi-neuron recordings implies that neural dynamics can be approximated by low-dimensional “latent” signals reflecting neural computations. However, […]

Kavli Affiliate: Li Zhao | Authors: mengya Zhao, Beiying Dai, Xiaodong Li, Yixin Zhang, Chun Qiao, Yaru Qin, Zhao Li, Qingmei Li, Shuzhen Wang, Yong Yang and Yijun Chen | Summary: Philadelphia chromosome-positive (Ph+) leukemia is a fatal hematological malignancy. Although standard treatments with tyrosine kinase inhibitors (TKI) have achieved remarkable success in prolonging patient […]

Kavli Affiliate: Winrich Freiwald | Authors: Pablo Polosecki, Sara C Steenrod, Heiko Stemmann and Winrich A. Freiwald | Summary: Attention is a central cognitive capability whose focus is thought to be directed by a spatial map coding behavioral priority. Here we tested the three defining properties of priority map theory with electrophysiological recordings from two […]

Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Deanna Arsala, Shengqian Xia, Cong Li, Mujahid Ali, Nicolas Svetec, Christopher Langer, Debora Sobreira, Ittai Eres, Dylan Sosa, Jianhai Chen, Li Zhang, Patrick Reilly, Alexander Guzzetta, J.J. Emerson, Peter Andolfatto, Li Zhao and Manyuan Long | Summary: Previous evolutionary models of duplicate gene evolution have overlooked the […]

Kavli Affiliate: Erich Jarvis | First 5 Authors: Matthew T Biegler, Kirubel Belay, Wei Wang, Christina Szi, Paul G Collier, Ji-Dung Luo, Bettina Haase, Gregory L. Gedman, Asha V. Sidhu, Elijah Harter, Carlos Rivera-Lopez, Kwame Amoako-Boadu, Olivier Fedrigo, Hagen U. Tilgner, Thomas T Carroll, Erich D. Jarvis and Anna L. Keyte | Summary: The diversity […]

Kavli Affiliate: Li Zhao | Authors: Isabel E Wassing, Atsuya Nishiyama, Moeri Hiruta, Qingyuan Jia, Reia Shikimachi, Amika Kikuchi, Keita Sugimura, Xin Hong, Yoshie Chiba, Junhui Peng, Christopher Jenness, Makoto Nakanishi, Li Zhao, Kyohei Arita and Hironori Funabiki | Summary: Mutations of the SNF2 family ATPase HELLS and its activator CDCA7 cause immunodeficiency-centromeric instability-facial anomalies […]