Probabilistic graph-based model uncovers previously unseen druggable vulnerabilities in major solid cancers

Posted by dbos Rockefeller

Kavli Affiliate: Franck Polleux; | Authors: Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J. Obara, Yui Sakurai-Saito, Jake Johnston, Yudan Du, Shogo Suga, Masafumi Tsuboi, Makoto Nakakido, Kouhei Tsumoto, Yusuke Kishi, Yukiko Gotoh, Chulhwan Kwak, Hyun-Woo Rhee, Jeong Kon Seo, Hidetaka Kosako, Clint Potter, Bridget Carragher, Jennifer Lippincott-Schwartz, Franck Polleux and Yusuke Hirabayashi […]


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Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Posted by dbos Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli; | Authors: Lorena Benedetti, Ruolin Fan, Aubrey V. Weigel, Andrew S. Moore, Patrick R. Houlihan, Mark Kittisopikul, Grace Park, Alyson Petruncio, Philip M. Hubbard, Song Pang, C. Shan Xu, Harald F. Hess, Stephan Saalfeld, Vidhya Rangaraju, David E. Clapham, Pietro De Camilli, Timothy A. Ryan and […]


Continue.. Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

The control of overt and covert attention across two nodes of the attention-control network

Posted by dbos Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Pablo Polosecki, Sara C Steenrod, Heiko Stemmann and Winrich A. Freiwald | Summary: Attention is a central cognitive capability whose focus is thought to be directed by a spatial map coding behavioral priority. Here we tested the three defining properties of priority map theory with electrophysiological recordings from two […]


Continue.. The control of overt and covert attention across two nodes of the attention-control network

Differential Control of Inhibitory and Excitatory Nerve Terminal Function by Mitochondria

Posted by dbos Rockefeller

Kavli Affiliate: Timothy A. Ryan | Authors: Kirsten Bredvik and Timothy A Ryan | Summary: Inhibitory neurons shape the brain’s computational landscape and rely on different cellular architectures and intrinsic properties than excitatory neurons. Maintenance of the overall balance of excitatory (E) versus inhibitory (I) drive is essential, as disruptions can lead to neuropathological conditions, […]


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Structure of the Flotillin Complex in a Native Membrane Environment

Posted by dbos Rockefeller

Kavli Affiliate: Roderick MacKinnon | Authors: Ziao Fu and Roderick MacKinnon; | Summary: In this study we used cryo-electron microscopy to determine the structures of the Flotillin protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) superfamily, from cell-derived vesicles without detergents. It forms a right-handed helical barrel consisting of 22 pairs of […]


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Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

Posted by klaurent Rockefeller

Kavli Affiliate: Jeffrey M. Friedman | Authors: Santiago R Unda, Roberta Marongiu, Lisa E Pomeranz, Jonathan P Dyke, Edward K Fung, Logan Grosenick, Rick Zirkel, Aldana M Antoniazzi, Sofya Norman, Conor M Liston, Chris B Schaffer, Nozomi Nishimura, Sarah A Stanley, Jeffrey M Friedman and Michael G Kaplitt | Summary: Regulating the activity of discrete […]


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Sampling Techniques and Genomic Analysis of Biological Material from Artworks

Posted by dbos Rockefeller

Kavli Affiliate: Thomas P. Sakmar | Authors: Rhonda K Roby, Rosana A Wiscovitch-Russo, Rebecca Hart, Amanda E Appel, Manija A Kazmi, Thomas Huber, Karina C Åberg, Thomas P Sakmar, José A Lorente and Norberto Gonzalez-Juarbe | Summary: The genomic analysis of biological material obtained from artwork or cultural heritage artifacts can be used to guide […]


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Magnetogenetic cell activation using endogenous ferritin

Posted by klaurent Rockefeller

Kavli Affiliate: Jeffrey M. Friedman | Authors: Lisa E Pomeranz, Rosemary Li, Xiaofei A Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, Daniel Gross, Matthew I Brier, George Vaisey, Putianqi Wang, Maria Jimenez-Gonzalez, Adolfo Garcia-Ocana, Jonathan Dordick, Jeffrey M. Friedman and Sarah A Stanley | Summary: The ability to precisely control the activity of defined cell […]


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Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling

Posted by dbos Rockefeller

Kavli Affiliate: Michael W. Young | Authors: Michael Young, David M Booth, David Smith, Marco Tigano, Gyorgy Hajnoczky and Suresh Joseph | Summary: The activation of IP3 receptor (IP3R) Ca2+ channels generates agonist-mediated Ca2+ signals that regulate a wide range of biological processes. It is therefore surprising that CRISPR induced loss of all three IP3R […]


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A Subcortical Feeding Circuit Linking Interoception to Jaw movement

Posted by dbos Rockefeller, UCSF

Kavli Affiliate: Jeffrey M. Friedman and Zachary Knight | Authors: Christin Kosse, Jessica Ivanov, Zachary Knight, Kyle Pellegrino and Jeffrey Friedman | Summary: The brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the neural pathways linking interoceptive inputs to outputs for feeding are poorly understood. Here we delineate […]


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