Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

Kavli Affiliate: A. James Hudspeth | Authors: Agnik Dasgupta, Caleb C. Reagor, Sang Peter Paik, Lauren M Snow, Adrian Jacobo and Albert Hudspeth | Summary: In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory […]


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Neural correlates of individual facial recognition in a social wasp

Kavli Affiliate: Winrich Freiwald | Authors: Christopher M. Jernigan, Winrich A. Freiwald and Michael J. Sheehan | Summary: Abstract Individual recognition is critical for social behavior across species. Whether recognition is mediated by circuits specialized for social information processing has been a matter of debate. Here we examine the neurobiological underpinning of individual visual facial […]


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Cellular and Molecular Basis of Leptin Resistance

Kavli Affiliate: Jeffrey M. Friedman | Authors: Bowen Tan, Kristina Hedbacker, Leah Kelly, Zhaoyue Zhang, Ji-Dung Luo, Joshua D. Rabinowitz and Jeffrey M. Friedman | Summary: Obese humans and diet induced obese mice (DIO) have high leptin levels and fail to respond to the exogenous hormone suggesting that obesity is caused by leptin resistance, the […]


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Leptin Activated Hypothalamic BNC2 Neurons Acutely Suppress Food Intake

Kavli Affiliate: Jeffrey M. Friedman | Authors: Han L. Tan, Luping Yin, Yuqi Tan, Jessica Ivanov, Kaja Plucinska, Anoj Ilanges, Brian R Herb, Putianqi Wang, Christin Kosse, Paul Cohen, Dayu Lin and Jeffrey M Friedman | Summary: Leptin is an adipose tissue hormone that maintains homeostatic control of adipose tissue mass by regulating the activity […]


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A Simple Subcortical Feeding Circuit Linking Interoceptive Inputs to Consummatory Behavior

Kavli Affiliate: Zachary Knight and Jeffrey M. Friedman | Authors: Christin Kosse, Jessica Ivanov, Zachary Knight, Kyle Pellegrino and Jeffrey Friedman | Summary: TThe brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the underlying circuitry linking inputs to outputs is unknown. Here we delineate a subcortical circuit in […]


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Social state gates vision using three circuit mechanisms in Drosophila

Kavli Affiliate: Vanessa Ruta | Authors: Catherine E. Schretter, Tom Hindmarsh Sten, Nathan Klapoetke, Mei Shao, Aljoscha Nern, Marisa Dreher, Daniel Bushey, Alice A. Robie, Adam L. Taylor, Kristin M. Branson, Adriane Otopalik, Vanessa Ruta and Gerald M. Rubin | Summary: Animals are often bombarded with visual information and must prioritize specific visual features based […]


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Whole-brain neural substrates of behavioral variability in the larval zebrafish

Kavli Affiliate: Alipasha Vaziri | Authors: Jason Manley and Alipasha Vaziri | Summary: Animals engaged in naturalistic behavior can exhibit a large degree of behavioral variability even under sensory invariant conditions. Such behavioral variability can include not only variations of the same behavior, but also variability across qualitatively different behaviors driven by divergent cognitive states, […]


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Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior

Kavli Affiliate: Leslie B. Vosshall and Michael Miller | Authors: Emely V. Zeledon, Leigh A. Baxt, Tanweer A. Khan, Mayako Michino, Michael Miller, David J. Huggins, Caroline S. Jiang, Leslie B. Vosshall and Laura B. Duvall | Summary: Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required […]


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Overexpression of PpGL2 from Prunus persica enhanced soybean drought tolerance

Kavli Affiliate: Li Zhao | Authors: Wei Li, Dahong Li, Li Zhao and Hongyan Li | Summary: The HD-ZIP transcription factor family plays crucial roles in plant growth and abiotic stress responses. While its diverse functions and regulatory mechanisms are well-documented, its role in conferring abiotic stress tolerance in peaches remains largely unexplored. Here, we […]


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The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions

Kavli Affiliate: Li Zhao | Authors: Junhui Peng, Nicolas Svetec, Henrik Molina and Li Zhao | Summary: Post-mating responses play a vital role in successful reproduction across diverse species. In fruit flies, sex peptide (SP) binds to sex peptide receptor (SPR), triggering a series of post-mating responses. However, the origin of SPR predates the emergence […]


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