Kavli Affiliate: Timothy A. Ryan | Authors: Kirsten Bredvik and Timothy A Ryan | Summary: Inhibitory neurons shape the brain’s computational landscape and rely on different cellular architectures and intrinsic properties than excitatory neurons. Maintenance of the overall balance of excitatory (E) versus inhibitory (I) drive is essential, as disruptions can lead to neuropathological conditions, […]

Kavli Affiliate: Roderick MacKinnon | Authors: Ziao Fu and Roderick MacKinnon; | Summary: In this study we used cryo-electron microscopy to determine the structures of the Flotillin protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) superfamily, from cell-derived vesicles without detergents. It forms a right-handed helical barrel consisting of 22 pairs of […]

Kavli Affiliate: Jeffrey M. Friedman | Authors: Santiago R Unda, Roberta Marongiu, Lisa E Pomeranz, Jonathan P Dyke, Edward K Fung, Logan Grosenick, Rick Zirkel, Aldana M Antoniazzi, Sofya Norman, Conor M Liston, Chris B Schaffer, Nozomi Nishimura, Sarah A Stanley, Jeffrey M Friedman and Michael G Kaplitt | Summary: Regulating the activity of discrete […]

Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Cong Li, Christopher B Langer, Nicolas Svetec and Li Zhao | Summary: Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the Drosophila germline has posed a significant technical barrier for comparative single-cell RNA-sequencing (scRNA-Seq) studies. […]

Kavli Affiliate: Thomas P. Sakmar | Authors: Rhonda K Roby, Rosana A Wiscovitch-Russo, Rebecca Hart, Amanda E Appel, Manija A Kazmi, Thomas Huber, Karina C Åberg, Thomas P Sakmar, José A Lorente and Norberto Gonzalez-Juarbe | Summary: The genomic analysis of biological material obtained from artwork or cultural heritage artifacts can be used to guide […]

Kavli Affiliate: Jeffrey M. Friedman | Authors: Lisa E Pomeranz, Rosemary Li, Xiaofei A Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, Daniel Gross, Matthew I Brier, George Vaisey, Putianqi Wang, Maria Jimenez-Gonzalez, Adolfo Garcia-Ocana, Jonathan Dordick, Jeffrey M. Friedman and Sarah A Stanley | Summary: The ability to precisely control the activity of defined cell […]

Kavli Affiliate: Michael W. Young | Authors: Michael Young, David M Booth, David Smith, Marco Tigano, Gyorgy Hajnoczky and Suresh Joseph | Summary: The activation of IP3 receptor (IP3R) Ca2+ channels generates agonist-mediated Ca2+ signals that regulate a wide range of biological processes. It is therefore surprising that CRISPR induced loss of all three IP3R […]

Kavli Affiliate: A. James Hudspeth | Authors: Agnik Dasgupta, Caleb C. Reagor, Sang Peter Paik, Lauren M Snow, Adrian Jacobo and Albert Hudspeth | Summary: In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory […]

Kavli Affiliate: Winrich Freiwald | Authors: Christopher M. Jernigan, Winrich A. Freiwald and Michael J. Sheehan | Summary: Abstract Individual recognition is critical for social behavior across species. Whether recognition is mediated by circuits specialized for social information processing has been a matter of debate. Here we examine the neurobiological underpinning of individual visual facial […]