End Binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of Dense Core Vesicles

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli, Kenneth Miller | Authors: Junhyun Park, Kenneth G. Miller, Pietro De Camilli and Shaul Yogev | Summary: Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, the C. elegans ortholog […]


Continue.. End Binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of Dense Core Vesicles

Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

Posted by klaurent Hopkins

Kavli Affiliate: Jeremy Nathans | Authors: Jie Wang, Amir Rattner and Jeremy Nathans | Summary: Bacterial meningitis is a major cause of morbidity and mortality, especially among infants and the elderly. Here we study mice to assess the response of each of the major meningeal cell types to early postnatal E. coli infection using single […]


Continue.. Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

Low Rate Hippocampal Delay Period Activity Encodes Behavioral Experience

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jill Leutgeb | Authors: Markos Athanasiadis, Stefano Masserini, Li Yuan, Dustin Fetterhoff, Jill K Leutgeb, Stefan Leutgeb and Christian Leibold | Summary: Remembering what just happened is a crucial prerequisite to form long-term memories but also for establishing and maintaining working memory. So far there is no general agreement about cortical mechanisms that […]


Continue.. Low Rate Hippocampal Delay Period Activity Encodes Behavioral Experience

Drosophila integrates visual evidence and counterevidence in self motion estimation

Posted by klaurent Yale

Kavli Affiliate: Damon Clark | Authors:Ryosuke Tanaka, Baohua Zhou, Margarida Agrochao, Bara A. Badwan, Braedyn Au, Natalia C. B. Matos and Damon A. Clark | Summary: In selecting a behavior, animals should weigh sensory evidence both for and against their beliefs about the world. For instance, animals use optic flow to estimate and control their […]


Continue.. Drosophila integrates visual evidence and counterevidence in self motion estimation

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtzr | Authors:Adrian C. Johnston, Gretchen M. Alicea, Cameron C. Lee, Payal V. Patel, Eban A. Hanna, Eduarda Vaz, Andre Forjaz, Zeqi Wan, Praful R. Nair, Yeongseo Lim, Tina Chen, Wenxuan Du, Dongjoo Kim, Tushar D. Nichakawade, Vito W. Rebecca, Challice L. Bonifant, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu and Denis […]


Continue.. Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

Posted by klaurent Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H. Nies, Marius T. Chiasseu, Guilin Wang, Ian R. Mackenzie and Stephen M. Strittmatter | Summary: Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that […]


Continue.. Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Variants in leucine rich repeat kinase 2 (LRRK2) that increase kinase activity confer risk for sporadic and familial forms of Parkinson’s disease. However, LRRK2-dependent cellular processes responsible for disease risk remain uncertain. Here we show that LRRK2 negatively regulates lysosome degradative […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Posted by klaurent Yale

Kavli Affiliate: Nenad Sestan | Authors: Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Victor Luria, Amir Karger, Yanhong Wang, Thomas M. Hyde, Joel E. Kleinman, Ty Voss, Elana J. Fertig, Joo-Heon Shin, Roland Bürli, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad […]


Continue.. Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Posted by klaurent UCSF

Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]


Continue.. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Multi-center integrated analysis of non-coding CRISPR screens

Posted by klaurent Hopkins

Kavli Affiliate: Michael Beer | Authors: David Yao, Josh Tycko, Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunahi Luo, Keith Siklenka, Galip Gurkan Yardimci, The ENCODE4 Consortium, Ryan Tewhey, Anshul Kundaje, William J. Greenleaf, Pardis […]


Continue.. Multi-center integrated analysis of non-coding CRISPR screens