Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Olivier Dubanet and Michael J. Higley | Summary: The ability of rodents to use visual cues for successful navigation and goal-directed behavior has been long appreciated, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the hippocampus and closely […]


Continue.. Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex

Fe-TAMLs as a new class of small molecule peroxidase probes for correlated light and electron microscopy

Posted by klaurent UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Stephen R Adams, Mason R Mackey, Ranjan Ramachandra, Thomas J Deerinck, Guillaume A Castillon, Sebastien Phan, Junru Hu, Daniela Boassa, John T Ngo and Mark H Ellisman | Summary: We introduce Fe-TAML, a small molecule-based peroxidase as a versatile new member of the correlated fluorescence and electron microscopy toolkit. […]


Continue.. Fe-TAMLs as a new class of small molecule peroxidase probes for correlated light and electron microscopy

Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance

Posted by dbos Yale

Kavli Affiliate: Sreeganga Chandra | Authors: Na Wang, Biqing Zhu, Mary Alice Allnutt, Rosalie M Grijalva, Hongyu Zhao and Sreeganga S Chandra | Summary: Synapse maintenance is essential for generating functional circuitry and decrement in this process is a hallmark of neurodegenerative disease. While we are beginning to understand the basis of synapse formation, much […]


Continue.. Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance

Scaling use of the rust fungus Puccinia punctiformis for biological control of Canada thistle (Cirsium arvense (L.) Scop.): First report on a U.S. statewide effort

Posted by dbos UCSD / Salk

Kavli Affiliate: Robert E. Clark | Authors: Dan W. Bean, Kristi Gladem, Karen Rosen, Alexander Blake, Robert E. Clark, Caitlin Henderson, John Kaltenbach, Joel Price, Emily L. Smallwood, Dana K. Berner, Stephen L. Young and Robert N. Schaeffer | Summary: Canada thistle (Cirsium arvense (L.) Scop., CT) is one of the worst weeds threatening temperate […]


Continue.. Scaling use of the rust fungus Puccinia punctiformis for biological control of Canada thistle (Cirsium arvense (L.) Scop.): First report on a U.S. statewide effort

MAP1B Regulates Cortical Neuron Interstitial Axon Branching Through the Tubulin Tyrosination Cycle

Posted by klaurent Hopkins

Kavli Affiliate: Alex Kolodkin | Authors: Jakub Ziak, Joelle Dorskind, Brian Trigg, Sriram Sudarsanam, Randal Hand and Alex L Kolodkin | Summary: Regulation of directed axon guidance and branching during development is essential for the generation of neuronal networks. However, the molecular mechanisms that underlie interstitial axon branching in the mammalian brain remain unresolved. Here, […]


Continue.. MAP1B Regulates Cortical Neuron Interstitial Axon Branching Through the Tubulin Tyrosination Cycle

Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: Marcus A. Triplett, Marta Gajowa, Benjamin Antin, Masato Sadahiro, Hillel Adesnik and Liam Paninski | Summary: Abstract Discovering how neural computations are implemented in the cortex at the level of monosynaptic connectivity requires probing for the existence of synapses from possibly thousands of presynaptic candidate neurons. Two-photon optogenetics has […]


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Leveraging the Adolescent Brain Cognitive Development Study to improve behavioral prediction from neuroimaging in smaller replication samples

Posted by klaurent UCSD / Salk

Kavli Affiliate: Timothy Brown, Anders Dale | Authors: Carolina Makowski, Timothy T Brown, Weiqi Zhao, Donald J Hagler, Pravesh Parekh, Hugh Garavan, Thomas E Nichols, Terry L Jernigan and Anders M Dale | Summary: Magnetic resonance imaging (MRI) is a popular and useful non-invasive method to map patterns of brain structure and function to complex […]


Continue.. Leveraging the Adolescent Brain Cognitive Development Study to improve behavioral prediction from neuroimaging in smaller replication samples

Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

Posted by klaurent UCSF

Kavli Affiliate: Michael Stryker | Authors: Wendy Xin, Megumi Kaneko, Richard H Roth, Albert Zhang, Sonia Nocera, Jun B Ding, Michael P Stryker and Jonah R Chan | Summary: BACKGROUND: Developmental myelination is a protracted process in the mammalian brain. One theory for why oligodendrocytes mature so slowly posits that myelination may stabilize neuronal circuits […]


Continue.. Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

Posted by klaurent Rockefeller

Kavli Affiliate: Mary E. Hatten, C. David Allis | Authors: Lijuan Feng, Douglas Barrows, Liangwen Zhong, Kart Matlik, Elizabeth G. Porter, Annaelle M. Djomo, Iris Yau, Alexey A. Soshnev, Thomas S. Carroll, Duancheng Wen, Mary E. Hatten, Benjamin A. Garcia and C. David Allis | Summary: Chromatin is a crucial regulator of gene expression and […]


Continue.. Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

Posted by klaurent Hopkins

Kavli Affiliate: Peter Searson | Authors: Yi Dong, Blake A Johns, Linhao Ruan, Maged Zeineldin, Albert Liu, Sumana Raychaudhuri, Ian Chiu, Jin Zhu, Barbara Smith, Nan Zhao, Peter Searson, Shigeki Watanabe, Mark Donowitz, Tatianna Chantelle Larman and Rong Li | Summary: Inflammation-associated fibroblasts (IAFs) are associated with the progression and drug resistance of chronic inflammatory […]


Continue.. Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling