Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum

Posted by klaurent Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Kert Mätlik, Matthew Baffuto, Laura Kus, Amit Laxmikant Deshmukh, David A Davis, Matthew R Paul, Thomas S Carroll, Marie-Christine Caron, Jean-Yves Masson, Christopher E Pearson and Nathaniel Heintz | Summary: Brain region-specific degeneration and somatic expansions of the mutant Huntingtin (mHTT) CAG tract are key features of Huntington’s disease […]


Continue.. Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum

Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Nisha Dhanushkodi, Swayam Prakash, Afshana Quadiri, Latifa Zayou, Ruchi Srivastava, Amin Mohammed Shaik, Berfin Suzer, Izabela Coimbra Ibraim, Gary Landucci, Delia F Tifrea, Mahmoud Singer, Leila Jamal, Robert A Edwards, Hawa Vahed, Lawrence Brown and LBACHIR BENMOHAMED | Summary: Significance SARS-CoV-2 Variants of Concern (VOCs) continue to evolve and […]


Continue.. Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: JAEKWANG JEONG, Jongwon Lee, Gabriel Talaia, Wonnam Kim, Junho Song, Juhyeon Hong, Kwangmin Yoo, David Gonzalez, Diana Athonvarangkul, Jaehun Shin, Pamela Dann, Ann Haberman, Lark Kyun Kim, Shawn Ferguson, Jungmin Choi and John Wysolmerski | Summary: Read More


Continue.. Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

Precision-engineered biomimetics: the human fallopian tube

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Ashleigh J Crawford, André Forjaz, Isha Bhorkar, Triya Roy, David Schell, Vasco Queiroga, Kehan Ren, Donald Kramer, Joanna Bons, Wilson Huang, Gabriella C Russo, Meng-Horng Lee, Birgit Schilling, Pei-Hsun Wu, Ie-Ming Shih, Tian-Li Wang, Ashley Kiemen and Denis Wirtz | Summary: The fallopian tube has an essential role in […]


Continue.. Precision-engineered biomimetics: the human fallopian tube

The Neonatal Gyrencephalic Cortex Maintains Regionally Distinct Streams of Neuroblasts

Posted by klaurent UCSF

Kavli Affiliate: David Rowitch | Authors: Jaeyeon Kim, Kadellyn Sandoval, Aunoy Poddar, Julia Chu, Emma Horton, Di Cui, Keira Nakamura, Theresa Bartels, Christian Wood, David H Rowitch, Hosung Kim, Chet C Sherwood, Boris W Kramer, Angela C Roberts, PABLO J ROSS, Duan Xu, Nicola J Robertson, Peng Ji, Elizabeth A Maga and Mercedes F Paredes […]


Continue.. The Neonatal Gyrencephalic Cortex Maintains Regionally Distinct Streams of Neuroblasts

Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD

Posted by klaurent UCSF

Kavli Affiliate: Kevin Bender | Authors: Chenyu Wang, Kimberly D Derderian, Elizabeth Hamada, Xujia Zhou, Andrew D Nelson, Henry Kyoung, Nadav Ahituv, Guy Bouvier and Kevin Bender | Summary: Children diagnosed with autism spectrum disorder (ASD) commonly present with sensory hypersensitivity, or abnormally strong reactions to sensory stimuli. Such hypersensitivity can be overwhelming, causing high […]


Continue.. Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD

Conjunctive vector coding and place coding in hippocampus share a common directional signal

Posted by klaurent Hopkins

Kavli Affiliate: James Knierim | Authors: Yue-Qing Zhou, Vyash Puliyadi, Xiaojing Chen, Joonhee Leo Lee, Lan-Yuan Zhang and James J Knierim | Summary: Vector coding is becoming increasingly understood as a major mechanism by which neural systems represent an animal’s location in both a global reference frame and a local, item-based reference frame. Landmark vector […]


Continue.. Conjunctive vector coding and place coding in hippocampus share a common directional signal

Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Posted by klaurent UCSF

Kavli Affiliate: John Rubenstein | Authors: Siavash Fazel Darbandi, Joon Yong An, Kenneth Lim, Nicholas F. Page, Lindsay Liang, Athena Ypsilanti, Eirene Markenscoff-Papadimitriou, Matthew W. State, Alex S Nord, Stephan J. Sanders and John L.R. Rubenstein | Summary: SUMMARY Many autism spectrum disorder (ASD)-associated genes act as transcriptional regulators (TRs). ChIP-seq was used to identify […]


Continue.. Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Judging the difficulty of perceptual decisions

Posted by klaurent Columbia

Kavli Affiliate: Michael Shadlen | Authors: Anne Löffler, Ariel Zylberberg, Michael N. Shadlen and Daniel M Wolpert | Summary: Deciding how difficult it is going to be to perform a task allows us to choose between tasks, allocate appropriate resources, and predict future performance. To be useful for planning, difficulty judgments should not require completion […]


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Random noise promotes slow heterogeneous synaptic dynamics important for robust working memory computation

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Nuttida Rungratsameetaweemana, Robert Kim, Thiparat Chotibut and Terrence Sejnowski | Summary: Recurrent neural networks (RNNs) based on model neurons that communicate via continuous signals have been widely used to study how cortical neurons perform cognitive tasks. Training such networks to perform tasks that require information maintenance over a brief […]


Continue.. Random noise promotes slow heterogeneous synaptic dynamics important for robust working memory computation