Microglial cannabinoid receptor type1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication

Posted by klaurent Hopkins

Kavli Affiliate: Solange Brown | Authors: Yuto Hasegawa, Juhyun Kim, Gianluca Ursini, Yan Jouroukhin, Xiaolei Zhu, Yu Miyahara, Feiyi Xiong, Samskruthi Madireddy, Mizuho Obayashi, Beat Lutz, Akira Sawa, Solange P Brown, Mikhail V Pletnikov and Atsushi Kamiya | Summary: Adolescent cannabis use increases the risk for cognitive impairments and psychiatric disorders. Cannabinoid receptor type 1 […]


Continue.. Microglial cannabinoid receptor type1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication

Host interactions of novel Crassvirales species belonging to multiple families infecting bacterial host, Bacteroides cellulosilyticus WH2

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Bhavya Papudeshi, Alejandro A Vega, Cole Souza, Sarah K Giles, Vijini Mallawaarachchi, Michael J. Roach, Michelle An, Nicole Jacobson, Katelyn McNair, Maria Fernanda Mora, Karina Pastrana, Lance Boling, Christopjer Leigh, Clarice Cram, Will S Plewa, Susanna R Grigson, George Bouras, Przemyslaw Decewicz, Antoni Luque, Lindsay Droit, Scott Allyn Handley, […]


Continue.. Host interactions of novel Crassvirales species belonging to multiple families infecting bacterial host, Bacteroides cellulosilyticus WH2

Collective dynamics of formin and microtubule and its crosstalk mediated by FHDC1

Posted by klaurent UCSF

Kavli Affiliate: Su Guo | Authors: Chee San Tong, Maohan Su, He Sun, Xiang Le Chua, Su Guo, Ravinraj S/O Ramaraj, Ann Gie Lee, Nicole Wen Pei Ong, Yansong Miao and Min Wu | Summary: The coordination between actin and microtubule network is crucial, yet our understanding of the underlying mechanisms remains limited. In this […]


Continue.. Collective dynamics of formin and microtubule and its crosstalk mediated by FHDC1

Exuberant de novo dendritic spine growth in mature neurons

Posted by klaurent Hopkins

Kavli Affiliate: Hey-Kyoung Lee | Authors: Sarah Kruessel, Ishana Deb, Seungkyu Son, Gabrielle Ewall, Minhyeok Chang, Hey-Kyoung Lee, Won Do Heo and Hyung-Bae Kwon | Summary: Dendritic spines are structural correlates of excitatory synapses maintaining stable synaptic communications. However, this strong spine-synapse relationship was mainly characterized in excitatory pyramidal neurons (PyNs), raising a possibility that […]


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Calcium-permeable AMPA receptors govern PV neuron feature selectivity

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles, Seth Blackshaw | Authors: Ingie Hong, Juhyun Kim, Thomas Hainmueller, Dong Won Kim, Richard C. Johnson, Soo Hyun Park, Nathachit Limjunyawong, Zhuonan Yang, David Cheon, Taeyoung Hwang, Amit Agarwal, Thibault Cholvin, Fenna M. Krienen, Steven A. McCarroll, Xinzhong Dong, David A. Leopold, Seth Blackshaw, Dwight E. Bergles, Marlene Bartos, Solange P. […]


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Effort cost of harvest affects decisions and movement vigor of marmosets during foraging

Posted by klaurent Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Paul Hage, In Kyu Jang, Vivian Looi, Mohammad Amin Fakharian, Simon P Orozco, Ehsan Sedaghat-Nejad, Jay Pi and Reza Shadmehr | Summary: We prefer to decline effortful rewards, but if the circumstances require it, we will move only slowly to harvest them. Why should economic variables such as reward […]


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Mesostriatal dopamine is sensitive to specific cue-reward contingencies

Posted by klaurent Hopkins

Kavli Affiliate: Patricia Janak | Authors: Eric Garr, Yifeng Cheng, Huijeong Jeong, Sara Brooke, Laia Castell, Aneesh Bal, Robin Magnard, Vijay Mohan K. Namboodiri and Patricia H. Janak | Summary: Learning causal relationships relies on understanding how often one event precedes another. To gain an understanding of how dopamine neuron activity and neurotransmitter release change […]


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The Cousa objective: a long working distance air objective for multiphoton imaging in vivo

Posted by klaurent Hopkins, Rockefeller, Yale

Kavli Affiliate: Michael Higley, Alipasha Vaziri, Kristina Nielsen | Authors: Che-Hang Yu, Yiyi Yu, Liam M. Adsit, Jeremy T. Chang, Jad Barchini, Andrew H. Moberly, Hadas Benisty, Jinkyung Kim, Brent K Young, Kathleen Heng, Deano M. Farinella, Austin Leikvoll, Rishaab Pavan, Rachel Vistein, Brandon R. Nanfito, David G. C. Hildebrand, Santiago Otero-Coronel, Alipasha Vaziri, Jeffery […]


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Simultaneous multi-site editing of individual genomes using retron arrays

Posted by klaurent UCSF

Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Santiago C Lopez, Matias Rojas-Montero, Chloe B Fishman and Seth L Shipman | Summary: Our understanding of genomics is limited by the scale of our genomic technologies. While libraries of genomic manipulations scaffolded on CRISPR gRNAs have been transformative, these existing approaches are typically multiplexed across genomes. […]


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Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Cheng Qian, Ying Xin, Cheng Qi, Hui Wang, Bryan C. Dong, Donald Zack, Seth Blackshaw, Samer Hattar, Feng-Quan Zhou and Jiang Qian | Summary: The progressive death of mature neurons often results in neurodegenerative diseases. While the previous studies have mostly focused on identifying intrinsic mechanisms controlling neuronal survival, […]


Continue.. Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells