Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection

Posted by klaurent Hopkins

Kavli Affiliate: Michael Beer | Authors: Jessica D. Resnick, Jo L. Wilson, Eddy Anaya, Abigail Conte, Maggie Li, William Zhong, Michael A. Beer and Andrew Pekosz | Summary: Primary differentiated human epithelial cell cultures have been widely used by researchers to study viral fitness and virus-host interactions, especially during the COVID19 pandemic. These cultures recapitulate […]


Continue.. Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection

Batch Effects are Causal Effects: Applications in Human Connectomics

Posted by klaurent Hopkins

Kavli Affiliate: Brian Caffo, Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Batch effects, undesirable sources of variance across multiple experiments, present significant challenges for scientific and clinical discoveries. Specifically, batch effects […]


Continue.. Batch Effects are Causal Effects: Applications in Human Connectomics

Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Max Pearson, Carl Haslam, Andrew Fosberry, Emma J Jones, Mark Reglinski, Robert J Edwards, Richard Ashley Lawrenson, Jonathan C Brown, Danuta Mossakowska, James Edward Pease and Shiranee Sriskandan | Summary: The Streptococcus pyogenes cell envelope protease (SpyCEP) is vital to streptococcal pathogenesis and disease progression. Despite its strong association […]


Continue.. Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Emergent neural dynamics and geometry for generalization in a transitive inference task

Posted by klaurent Columbia

Kavli Affiliate: Daphna Shohamy | Authors: Kenneth Kay, Natalie Biderman, Ramin Khajeh, Manuel Beiran, Christopher J Cueva, Daphna Shohamy, Greg Jensen, Xue-Xin Wei, Vincent P Ferrera and L F Abbott | Summary: Relational cognition — the ability to infer relationships that generalize to novel combinations of objects — is fundamental to human and animal intelligence. […]


Continue.. Emergent neural dynamics and geometry for generalization in a transitive inference task

Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks

Posted by klaurent Hopkins

Kavli Affiliate: Adam S. Charles | Authors: Ahmed El Hady, Daniel Y Takahashi, Ruolan Sun, Oluwateniola Akinwale, Tyler Boyd-Meredith, Yisi Zhang, Adam Charles and Carlos Brody | Summary: Functional ultrasound imaging (fUS) is an emerging imaging technique that indirectly measures neural activity via changes in blood volume. To date it has not been used to […]


Continue.. Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks

Hallucination proneness alters sensory feedback processing in self-voice production

Posted by klaurent Hopkins

Kavli Affiliate: David Linden | Authors: Suvarnalata Xanthate Duggirala, Michael Schwartze, Lisa K Goller, David E.J. Linden, Ana Pinheiro and Sonja A Kotz | Summary: Background: Sensory suppression occurs when hearing ones self-generated voice, as opposed to passively listening to ones own voice. Quality changes of sensory feedback to the self-generated voice can increase attentional […]


Continue.. Hallucination proneness alters sensory feedback processing in self-voice production

Mechano-induced homotypic patterned domain formation by monocytes

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Jingyi Zhu, Yufei Wu, Ashley Kiemen, Sean Sun and Denis Wirtz | Summary: Matrix stiffness and corresponding mechano-signaling play indispensable roles in cellular phenotypes and functions. How tissue stiffness influences the behavior of monocytes, a major circulating leukocyte of the innate system, and how it may promote […]


Continue.. Mechano-induced homotypic patterned domain formation by monocytes

A neural mechanism for discriminating social threat from social safety

Posted by klaurent Columbia

Kavli Affiliate: Steven Siegelbaum | Authors: Pegah Kassraian, Shivani K. Bigler, Diana M. Gilly, Neilesh Shrotri and Steven A. Siegelbaum | Summary: The ability to distinguish a threatening from non-threatening conspecific based on past experience is critical for adaptive social behaviors. Although recent progress has been made in identifying the neural circuits that contribute to […]


Continue.. A neural mechanism for discriminating social threat from social safety

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Camille N. Pierre, Lily E. Adams, Kara Anasti, Derrick Goodman, Sherry Stanfield-Oakley, John M. Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J. Edwards, S. Munir Alam, Guido Ferrari, Georgia D. Tomaras, Barton F. Haynes, Ralph S. Baric and Kevin Saunders | Summary: Antibodies perform both neutralizing and non-neutralizing […]


Continue.. Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC)

Posted by klaurent Hopkins, UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Rong Zablocki, Bohan Xu, Chun-Chieh Fan and Wesley K. Thompson | Summary: Here we present a development of the novel Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC) model. BRAINIAC allows for both estimation of total variance explained by all features for a given cognitive phenotype, as well […]


Continue.. A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC)