Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Max Pearson, Carl Haslam, Andrew Fosberry, Emma J Jones, Mark Reglinski, Robert J Edwards, Richard Ashley Lawrenson, Jonathan C Brown, Danuta Mossakowska, James Edward Pease and Shiranee Sriskandan | Summary: The Streptococcus pyogenes cell envelope protease (SpyCEP) is vital to streptococcal pathogenesis and disease progression. Despite its strong association […]


Continue.. Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Emergent neural dynamics and geometry for generalization in a transitive inference task

Posted by klaurent Columbia

Kavli Affiliate: Daphna Shohamy | Authors: Kenneth Kay, Natalie Biderman, Ramin Khajeh, Manuel Beiran, Christopher J Cueva, Daphna Shohamy, Greg Jensen, Xue-Xin Wei, Vincent P Ferrera and L F Abbott | Summary: Relational cognition — the ability to infer relationships that generalize to novel combinations of objects — is fundamental to human and animal intelligence. […]


Continue.. Emergent neural dynamics and geometry for generalization in a transitive inference task

Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks

Posted by klaurent Hopkins

Kavli Affiliate: Adam S. Charles | Authors: Ahmed El Hady, Daniel Y Takahashi, Ruolan Sun, Oluwateniola Akinwale, Tyler Boyd-Meredith, Yisi Zhang, Adam Charles and Carlos Brody | Summary: Functional ultrasound imaging (fUS) is an emerging imaging technique that indirectly measures neural activity via changes in blood volume. To date it has not been used to […]


Continue.. Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks

Hallucination proneness alters sensory feedback processing in self-voice production

Posted by klaurent Hopkins

Kavli Affiliate: David Linden | Authors: Suvarnalata Xanthate Duggirala, Michael Schwartze, Lisa K Goller, David E.J. Linden, Ana Pinheiro and Sonja A Kotz | Summary: Background: Sensory suppression occurs when hearing ones self-generated voice, as opposed to passively listening to ones own voice. Quality changes of sensory feedback to the self-generated voice can increase attentional […]


Continue.. Hallucination proneness alters sensory feedback processing in self-voice production

Mechano-induced homotypic patterned domain formation by monocytes

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Jingyi Zhu, Yufei Wu, Ashley Kiemen, Sean Sun and Denis Wirtz | Summary: Matrix stiffness and corresponding mechano-signaling play indispensable roles in cellular phenotypes and functions. How tissue stiffness influences the behavior of monocytes, a major circulating leukocyte of the innate system, and how it may promote […]


Continue.. Mechano-induced homotypic patterned domain formation by monocytes

A neural mechanism for discriminating social threat from social safety

Posted by klaurent Columbia

Kavli Affiliate: Steven Siegelbaum | Authors: Pegah Kassraian, Shivani K. Bigler, Diana M. Gilly, Neilesh Shrotri and Steven A. Siegelbaum | Summary: The ability to distinguish a threatening from non-threatening conspecific based on past experience is critical for adaptive social behaviors. Although recent progress has been made in identifying the neural circuits that contribute to […]


Continue.. A neural mechanism for discriminating social threat from social safety

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Camille N. Pierre, Lily E. Adams, Kara Anasti, Derrick Goodman, Sherry Stanfield-Oakley, John M. Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J. Edwards, S. Munir Alam, Guido Ferrari, Georgia D. Tomaras, Barton F. Haynes, Ralph S. Baric and Kevin Saunders | Summary: Antibodies perform both neutralizing and non-neutralizing […]


Continue.. Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC)

Posted by klaurent Hopkins, UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Rong Zablocki, Bohan Xu, Chun-Chieh Fan and Wesley K. Thompson | Summary: Here we present a development of the novel Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC) model. BRAINIAC allows for both estimation of total variance explained by all features for a given cognitive phenotype, as well […]


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Microglial cannabinoid receptor type1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication

Posted by klaurent Hopkins

Kavli Affiliate: Solange Brown | Authors: Yuto Hasegawa, Juhyun Kim, Gianluca Ursini, Yan Jouroukhin, Xiaolei Zhu, Yu Miyahara, Feiyi Xiong, Samskruthi Madireddy, Mizuho Obayashi, Beat Lutz, Akira Sawa, Solange P Brown, Mikhail V Pletnikov and Atsushi Kamiya | Summary: Adolescent cannabis use increases the risk for cognitive impairments and psychiatric disorders. Cannabinoid receptor type 1 […]


Continue.. Microglial cannabinoid receptor type1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication

Host interactions of novel Crassvirales species belonging to multiple families infecting bacterial host, Bacteroides cellulosilyticus WH2

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Bhavya Papudeshi, Alejandro A Vega, Cole Souza, Sarah K Giles, Vijini Mallawaarachchi, Michael J. Roach, Michelle An, Nicole Jacobson, Katelyn McNair, Maria Fernanda Mora, Karina Pastrana, Lance Boling, Christopjer Leigh, Clarice Cram, Will S Plewa, Susanna R Grigson, George Bouras, Przemyslaw Decewicz, Antoni Luque, Lindsay Droit, Scott Allyn Handley, […]


Continue.. Host interactions of novel Crassvirales species belonging to multiple families infecting bacterial host, Bacteroides cellulosilyticus WH2