Kavli Affiliate: David Kleinfeld | Authors: Harish Kannan, Paul Sun, Tolga Çağlar, Pantong Yao, Brian R Taylor, Kinshuk Sahu, Daotong Ge, Matteo Mori, Mya Warren, David Kleinfeld, JiaJia Dong, Bo Li and Terence Hwa | Summary: Bacterial colony growth on hard agar is commonplace in microbiology; yet, what occurs inside a growing colony is complex […]
Kavli Affiliate: Michael Keiser | Authors: William J. Connell, Kristle Garcia, Hani Goodarzi and Michael J. Keiser | Summary: Chemical probes interrogate disease mechanisms at the molecular level by linking genetic changes to observable traits. However, comprehensive chemical screens in diverse biological models are impractical. To address this challenge, we developed ChemProbe, a model that […]
Kavli Affiliate: Timothy Brown | Authors: Richard J McDowell, Altug Didikoglu, Tom Woelders, Mazie J Gatt, Roelof A. Hut, Timothy M Brown and Robert J Lucas | Summary: Background Light is a key environmental regulator of physiology and behaviour. Mistimed or insufficient light disrupts circadian rhythms and is associated with impaired health and well-being across […]
Kavli Affiliate: Cynthia F. Moss | Authors: Michael A Pardo, Kurt Fristrup, David S Lolchuragi, Joyce Poole, Petter Granli, Cynthia Moss, Iain Douglas-Hamilton and George Wittemyer | Summary: Personal names are a universal feature of human language, yet few analogs exist in other species. While dolphins and parrots address conspecifics by imitating the calls of […]
Kavli Affiliate: Seth Shipman | Authors: Manuel Peter, Seth Shipman and Jeffrey D Macklis | Summary: Differentiation of human pluripotent stem cells (hPSC) into distinct neuronal populations holds substantial potential for disease modeling in vitro, toward both elucidation of pathobiological mechanisms and screening of potential therapeutic agents. For successful differentiation of hPSCs into subtype-specific neurons […]
Kavli Affiliate: Roger Nicoll | Authors: XIUMIN CHEN, Qixu Cai, jing zhou, Samuel J Pleasure, Howard Schulman, Mingjie Zhang and Roger A Nicoll | Summary: CaMKII plays a critical role in long-term potentiation (LTP), a well-established model for learning and memory through the enhancement of synaptic transmission. Biochemical studies indicate that CaMKII catalyzes a phosphotransferase […]
Kavli Affiliate: Mark Ellisman | Authors: Cristiane dos Santos, Shristi Shrestha, Matthew A Cottam, Guy Perkins, Varda Lev-Ram, Birbickram Roy, Christopher Acree, Keun-Young Kim, Thomas Deerinck, Melanie Cutler, Danielle Dean, Jean Philippe Cartailler, Patrick E MacDonald, Martin W Hetzer, Mark H Ellisman and Rafael Arrojo e Drigo | Summary: Caloric restriction (CR) extends organismal lifespan […]
Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Jonathan S Marvin, Alexandros C Kokotos, Mukesh Kumar, Camila Pulido, Ariana N Tkachuk, Jocelyn Shuxin Yao, Timothy A Brown and Timothy A Ryan | Summary: We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular […]
Kavli Affiliate: Wei Min | Authors: Hannah Dayton, Julie Kiss, Mian Wei, Shradha Chauhan, Emily LaMarre, William Cole Cornell, Chase J. Morgan, Anuradha Janakiraman, Wei Min, Raju Tomer, Alexa Price-Whelan, Jasmine A Nirody and Lars E.P. Dietrich | Summary: Cells must access resources to survive, and the anatomy of multicellular structures influences this access. In […]
Kavli Affiliate: Nathaniel Sawtell, Liam Paninski | Authors: Zhiwen Ye, Andrew M. Shelton, Jordan R. Shaker, Julien Boussard, Jennifer Colonell, Sahar Manavi, Susu Chen, Charlie Windolf, Cole Hurwitz, Tomoyuki Namima, Federico Pedraja, Shahaf Weiss, Bogdan Raducanu, Torbjørn V. Ness, Gaute T. Einevoll, Gilles Laurent, Nathaniel B. Sawtell, Wyeth Bair, Anitha Pasupathy, Carolina Mora Lopez, Barun […]