Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Elleke Tissink, Alexey A Shadrin, Dennis van der Meer, Nadine Parker, Guy Hindley, Daniel Roelfs, Oleksandr Frei, Chun Chieh Fan, Mats Nagel, Terje Naerland, Magdalena Budisteanu, Srdjan Djurovic, Lars T. Westlye, Martijn van den Heuvel, Danielle Posthuma, Tobias Kaufmann, Anders M. Dale and Ole Andreassen | Summary: Genetic pleiotropy […]


Continue.. Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Temperate gut phages are prevalent, diverse, and predominantly inactive

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Sofia Dahlman, Laura Avellaneda-Franco, Ciaren Kett, Dinesh Subedi, Remy B Young, Jodee A. Gould, Emily L Rutten, Emily L Gilliver, Christopher JR Turkington, Neda Nezam-Abadi, Juris A Grasis, Dena Lyras, Professor, Robert A Edwards, Samuel C Forster and Jeremy J Barr | Summary: Large-scale metagenomic and data mining efforts […]


Continue.. Temperate gut phages are prevalent, diverse, and predominantly inactive

Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein

Posted by klaurent UCSF

Kavli Affiliate: Yifan Cheng | Authors: Armin Adly, Maxine Bi, Christopher Carlson, Abdullah Muhammad Syed, Alison Ciling, Jennifer Doudna, Yifan Cheng and David O. Morgan | Summary: The Nucleocapsid (N) protein of SARS-CoV-2 compacts the RNA genome into viral ribonucleoprotein (vRNP) complexes within virions. Assembly of vRNPs is inhibited by phosphorylation of the N protein […]


Continue.. Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein

Estimating the Total Variance Explained by Whole-Brain Imaging for Zero-inflated Outcomes

Posted by klaurent UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Junting Ren, Robert John Loughnan, Bohan Xu, Wesley K. Thompson and Chun Chieh Fan | Summary: Zero-inflated outcomes are very common in behavioral data, particularly for responses to psychological questionnaires. Modeling these challenging distributions is further exacerbated by the absence of established statistical models capable of characterizing total signals […]


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Gene editing in the Chagas disease vector Rhodnius prolixus by Cas9-mediated ReMOT Control

Posted by klaurent UCSD / Salk

Kavli Affiliate: Ethan Bier | Authors: Leonardo Lima, Mateus Berni, Jamile Mota, Daniel Bressan, Alison Julio, Robson Cavalcante, Vanessa Macias, Zhiqian Li, Jason L. Rasgon, Ethan Bier and Helena Marcolla Araujo | Summary: Rhodnius prolixus is currently the model vector of choice for studying Chagas disease transmission, a debilitating disease caused by Trypanosoma cruzi parasites. […]


Continue.. Gene editing in the Chagas disease vector Rhodnius prolixus by Cas9-mediated ReMOT Control

Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids

Posted by klaurent Yale

Kavli Affiliate: Flora Vaccarino | Authors: Davide Capauto, Yifan Wang, Feinan Wu, Scott Norton, Jessica Mariani, Fumitaka Inoue, Gregory E. Crawford, The PsychENCODE Consortium, Nadav Ahituv, Alexej Abyzov and Flora M. Vaccarino | Summary: bstract Regulation of gene expression through enhancers is one of the major processes shaping the structure and function of the human […]


Continue.. Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids

Flexible regulation of representations on a drifting manifold enables long-term stable complex neuroprosthetic control

Posted by klaurent UCSF

Kavli Affiliate: Edward Chang, Karunesh Ganguly | Authors: NIKHILESH NATRAJ, Sarah Seko, Reza Abiri, Hongyi Yan, Yasmin Graham, Adelyn Tu-Chan, Edward F Chang and Karunesh Ganguly | Summary: The nervous system needs to balance the stability of neural representations with plasticity. It is unclear what is the representational stability of simple actions, particularly those that […]


Continue.. Flexible regulation of representations on a drifting manifold enables long-term stable complex neuroprosthetic control

DARTsort: A modular drift tracking spike sorter for high-density multi-electrode probes

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: Julien Boussard, Charlie Windolf, Cole Hurwitz, Hyun Dong Lee, Han Yu, Olivier Winter and Liam Paninski | Summary: With the advent of high-density, multi-electrode probes, there has been a renewed interest in developing robust and scalable algorithms for spike sorting. Current spike sorting approaches, however, struggle to deal with […]


Continue.. DARTsort: A modular drift tracking spike sorter for high-density multi-electrode probes

Brain-wide representations of prior information in mouse decision-making

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: Charles Findling, Felix Hubert, International Brain Laboratory, Luigi Acerbi, Brandon Benson, Julius Benson, Daniel Birman, Niccolò Bonacchi, Matteo Carandini, Joana A Catarino, Gaelle A Chapuis, Anne K Churchland, Yang Dan, Eric EJ DeWitt, Tatiana A Engel, Michele Fabbri, Mayo Faulkner, Ila Rani Fiete, Laura Freitas-Silva, Berk Gerçek, Kenneth D […]


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Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells

Posted by klaurent Yale

Kavli Affiliate: Pietro De Camilli | Authors: Chase Amos, Peng Xu and Pietro De Camilli | Summary: Mutations of the bridge-like lipid transport protein VPS13A and of the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS) respectively, two similar conditions involving neurodegeneration and deformed erythrocytes (acanthocytes). VPS13A binds XK, suggesting a […]


Continue.. Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells