Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, David Kleinfeld, Beth Friedman and Yoav Freund | Summary: One routine and necessary, yet time-consuming task in neuroanatomy is the annotation of labeled cells relative to the background. Currently, staining and imaging techniques enable the marking of specific cell groups with fluorescent dyes. Modern high throughput scanning […]
Kavli Affiliate: Arnold R. Kriegstein | Authors: Dmitry Velmeshev, Yonatan Perez, Zihan Yan, Jonathan E Valencia, David R Castaneda-Castellanos, Li Wang, Lucas Schirmer, Simone Mayer, Brittney Wick, Shaohui Wang, Tomasz J. Nowakowski, Mercedes Paredes, Eric J. J. Huang and Arnold Kriegstein | Summary: We analyze more than 700,000 single-nucleus RNA-seq profiles from 106 donors during […]
Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Azucena Perez-Canamas, Hongping Ye, Xianlin Han and Stephen M. Strittmatter | Summary: TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-19. Additionally, recent studies have identified amyloid fibrils of […]
Kavli Affiliate: John Serences | Authors: Margaret M Henderson, John T Serences and Nuttida Rungratsameetaweemana | Summary: Everyday visual search tasks require objects to be categorized according to behavioral goals. For example, when searching for an apple at the supermarket, one might first find the Granny Smith apples by separating all visible apples into the […]
Kavli Affiliate: Robert Edwards | Authors: Vijini Mallawaarachchi, Michael J. Roach, Przemyslaw Decewicz, Bhavya Papudeshi, Sarah K Giles, Susanna R Grigson, George Bouras, Ryan D Hesse, Laura K Inglis, Abbey LK Hutton, Elizabeth A Dinsdale and Robert A Edwards | Summary: Microbial communities influence both human health and different environments. Viruses infecting bacteria, known as […]
Kavli Affiliate: Peter Walter | Authors: Rochelle Coulson, Valentina Frattini, Caitlin Moyer, Jennifer Hodges, Peter Walter, Philippe Mourrain, Yi Zuo and Gordon Wang | Summary: Fragile X syndrome (FXS) is caused by the functional loss of Fragile X messenger ribonucleoprotein (FMRP), a translational regulator that binds the transcripts of many proteins involved in synaptic function […]
Kavli Affiliate: Xin Duan | Authors: Wendy W.S. Yue, Kouki K. Touhara, Kenichi Toma, Xin Duan and David Julius | Summary: After injury, mammalian spinal cords develop scars to seal off the damaged area and prevent further injury. However, excessive scarring can hinder neural regeneration and functional recovery (1, 2). These competing actions underscore the […]
Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M. Vaccarino | Summary: Cell differentiation involves shifts in chromatin organization allowing transcription […]
Kavli Affiliate: Alipasha Vaziri, Jeffrey M. Friedman | Authors: Bowen Tan, Caleb J Browne, Tobias Nobauer, Alipasha Vaziri, Jeffrey M. Friedman and Eric J. Nestler | Summary: Addiction prioritizes drug use over innate needs by hijacking brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping and in vivo single-neuron […]
Kavli Affiliate: Michael Miller | Authors: Jamil Mahmud, Brittany W Geiler, Juthi Biswas, Michael J Miller, Julia E Myers, Stephen M Matthews, Amanda B Wass, Christine M O’Connor and Gary C Chan | Summary: Establishing a non-productive quiescent/silent infection within monocytes is essential for spread of human cytomegalovirus (HCMV). Yet, how HCMV establishes a quiescent […]