Kavli Affiliate: Adam S. Charles | Authors: Augustine Xiaoran Yuan, Jennifer I Colonell, Anna Lebedeva, Michael Okun, Adam Charles and Timothy D Harris | Summary: Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. New advances in high density extracellular electrophysiology recording probes, […]
Kavli Affiliate: Roderick MacKinnon | Authors: Gonzalo Pérez-Mitta, Yeliz Sezgin, Weiwei Wang and Roderick MacKinnon | Summary: Abstract Integral membrane proteins (IMPs) constitute a large fraction of organismal proteomes, playing fundamental roles in physiology and disease. Despite their importance, the mechanisms underlying dynamic features of IMPs, such as anomalous diffusion, protein-protein interactions, and protein clustering, […]
Kavli Affiliate: Seth Shipman | Authors: Asim G. Khan, Matías Rojas-Montero, Alejandro González-Delgado, Santiago C. Lopez, Rebecca F. Fang and Seth L. Shipman | Summary: Abstract Retrons are bacterial immune systems that use reverse transcribed DNA as a detector of phage infection. They are also increasingly deployed as a component of biotechnology. For genome editing, […]
Kavli Affiliate: Razi Haque Christoph Kirst Loren Frank | Authors: Kyu Hyun Lee, Eric L. Denovellis, Ryan Ly, Jeremy Magland, Jeff Soules, Alison E Comrie, Daniel P Gramling, Jennifer A Guidera, Rhino Nevers, Philip Adenekan, Chris Brozdowski, Sam Bray, Emily Monroe, Ji Hyun Bak, Michael Coulter, Xulu Sun, Andrew Tritt, Oliver Oliver Ruebel, Thinh Nguyen, […]
Kavli Affiliate: Anirvan Nandy | Authors: Mitchell P. Morton, Sachira Denagamage, Nyomi V. Hudson and Anirvan S. Nandy | Summary: Crowding, the impaired ability to accurately recognize a target stimulus among distractors, is a major bottleneck in visual perception. The spatial configuration of distractors in relation to the target profoundly influences perceptual fidelity. Notably, when […]
Kavli Affiliate: Joshua Vogelstein | Authors: Xinhui Li, Nathalia Bianchini Esper, Lei Ai, Steve Giavasis, Hecheng Jin, Eric Feczko, Ting Xu, Jon Clucas, Alexandre Franco, Anibal Solon Heinsfeld, Azeez Adebimpe, Joshua T. Vogelstein, Chao-Gan Yan, Oscar Esteban, Russell A. Poldrack, Cameron Craddock, Damien Fair, Theodore Satterthwaite, Gregory Kiar and Michael P. Milham | Summary: Abstract […]
Kavli Affiliate: Darcy Peterka | Authors: Robert M. Lees, Isaac H. Bianco, Robert A. A. Campbell, Natalia Orlova, Darcy S. Peterka, Bruno Pichler, Spencer LaVere Smith, Dimitri Yatsenko, Che-Hang Yu and Adam M. Packer | Summary: Abstract The goal of this protocol is to enable better characterisation of multiphoton microscopy hardware across a large user […]
Kavli Affiliate: Kenneth Miller | Authors: Serena Di Santo, Mario Dipoppa, Andreas Keller, Morgane Roth, Massimo Scanziani and Kenneth D Miller | Summary: Abstract Sensory systems must combine local features with context to infer meaning. Accordingly, context profoundly influences neural responses. We developed a unified circuit model demonstrating how feedforward and feedback inputs are integrated […]
Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, Beth Friedman, Jun Takatoh, Fan Wang, David Kleinfeld and Yoav Freund | Summary: One of the important yet labor intensive tasks in neuroanatomy is the identification of select populations of cells. Current high-throughput techniques enable marking cells with histochemical fluorescent molecules as well as through the genetic […]
Kavli Affiliate: Sidney Strickland | Authors: Pradeep K Singh, Elisa Nicoloso Simoes-Pires, Zu-Lin Chen, Daniel Torrente, Marissa Calvano, Anurag Sharma, Sidney Strickland and Erin H Norris | Summary: Proteinaceous brain inclusions, neuroinflammation, and vascular dysfunction are common pathologies in Alzheimer’s disease (AD). Vascular deficits include a compromised blood-brain barrier, which can lead to extravasation of […]