Kavli Affiliate: Reza Abbasi Asl | Authors: Robert Cahill, Yu Wang, Alex Lee, Hongkui Zeng, Bin Yu, Bosiljka Tasic and Reza Abbasi-Asl | Summary: The growth of large-scale spatial gene expression data requires new computational tools to extract major trends in gene expression in their native spatial context. Here, we describe an unsupervised and interpretable […]
Kavli Affiliate: Winrich Freiwald | Authors: Farid Aboharb, Stephen Serene, Julia Sliwa and Winrich A Freiwald | Summary: In the primate brain the frontal lobes support complex functions, including social cognition. Understanding the functional organization of these regions requires an approach for rich functional characterization. Here we used a novel paradigm, the visual exploration of […]
Kavli Affiliate: Stefano Fusi | Authors: Sean Chih-Hsiung Lim, Stefano Fusi and Rene Hen | Summary: The ventral hippocampus is a critical node in the distributed brain network that controls anxiety. Using miniature microscopy and calcium imaging, we recorded ventral CA1 (vCA1) neurons in freely moving mice as they explored variants of classic behavioral assays […]
Kavli Affiliate: Nicola Allen | Authors: Ashley N Brandebura, Quinn N Asbell, Mariel Kristine B Micael and Nicola J Allen | Summary: Neuronal dendrite structure and synapse formation is tightly regulated during development to promote proper connectivity. Astrocyte-secreted proteins act as guidance and pro-synaptogenic factors, and astrocyte protein secretion is dysregulated in neurodevelopmental disorders with […]
Kavli Affiliate: Michael Miller, Ekaterina V. Vinogradova | Authors: Jared R Ramsey, Patrick M M Shelton, Tyler K. Heiss, Paul Dominic B Olinares, Lauren E Vostal, Heather Soileau, Michael Grasso, Sara Warrington, Stephanie Adaniya, Michael Miller, Shan Sun, David J Huggins, Robert W Myers, Brian T Chait, Ekaterina V Vinogradova and Tarun M Kapoor | […]
Kavli Affiliate: Mark Ellisman | Authors: Guillaume A Castillon, Sebastien Phan, Junru Hu, Daniela Boassa, Stephen R Adams and Mark H Ellisman | Summary: The binding and interaction of proteins with nucleic acids such as DNA and RNA constitutes a fundamental biochemical and biophysical process in all living organisms. Identifying and visualizing such temporal interactions […]
Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Our understanding of pathogen spillover is largely based on viral systems associated with bats. Bacterial infections of zoonotic origin also pose a significant public health burden, many of which are associated with small […]
Kavli Affiliate: Tatyana Sharpee | Authors: Martin Alvarez-Kuglen, Delany Rodriguez, Haodong Qin, Kenta Ninomiya, Lorenzo Fiengo, Chen Farhy, Aaron Havas, Wei-Mien Hsu, Gen-Sheng Feng, Amanda Roberts, Rozalyn M Anderson, Manuel Serrano, Peter D Adams, Tatyana O Sharpee and Alexey Terskikh | Summary: Biomarkers of biological age that predict the risk of disease and expected lifespan […]
Kavli Affiliate: Terrence Sejnowski | Authors: Adam Husar, Mariam Ordyan, Guadalupe C Garcia, Joel G Yancey, Ali S Saglam, James Faeder, Thomas M Bartol, Jr., Mary B Kennedy and Terrence J Sejnowski | Summary: Biochemical signaling pathways in living cells are often highly organized into spatially segregated volumes, membranes, scaffolds, subcellular compartments, and organelles comprising […]
Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Yann S Mineur, Richard B Crouse, Ian M Etherington, Hanna Yousuf, Jessica J Na and Marina R Picciotto | Summary: Increased brain levels of acetylcholine (ACh) are observed in subsets of patients with depression and increasing ACh levels chronically can precipitate stress-related behaviors in humans and […]